Homo sapiens

Cd1c-positive myeloid dendritic cell Cd141-positive myeloid dendritic cell Plasmacytoid dendritic cell Axl+ dendritic cell, human

Blood

34-year-old stage 65-year-old stage 26-year-old stage 61-year-old stage 30-year-old stage 29-year-old stage 56-year-old stage 55-year-old stage 28-year-old stage 57-year-old stage 12-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 25-year-old stage 32-year-old stage 33-year-old stage 64-year-old stage 62-year-old stage 60-year-old stage 31-year-old stage 36-year-old stage 63-year-old stage 11-year-old stage 27-year-old stage

Cytomegalovirus infection Normal

Female Male

10x 3' v3

Cell

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Autosomal dominant polycystic kidney disease

Male

Slide-seqv2

Homo sapiens

Inhibitory interneuron

Prefrontal cortex

66-year-old stage 89-year-old stage 87-year-old stage 71-year-old stage 61-year-old stage 68-year-old stage 57-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 67-year-old stage 62-year-old stage 79-year-old stage 73-year-old stage

Normal Alzheimer disease

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Cortex of kidney

64-year-old stage

Normal

Female

Slide-seqv2

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Lamp5 lhx6 neuron Cerebellar inhibitory gabaergic interneuron Ependymal cell Microglial cell Choroid plexus epithelial cell Bergmann glial cell B cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Unipolar brush cell Fibroblast

Nucleus of medulla oblongata

42-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Neutrophil Mast cell Cd8-positive, alpha-beta t cell Cd4-positive helper t cell Macrophage Innate lymphoid cell Plasma cell B cell Dendritic cell

Gingiva Buccal mucosa Hard palate Soft palate

21-year-old stage 34-year-old stage 26-year-old stage Sixth decade stage 61-year-old stage 30-year-old stage 39-year-old stage 29-year-old stage 28-year-old stage 51-year-old stage 57-year-old stage 24-year-old stage 35-year-old stage Seventh decade stage 32-year-old stage 33-year-old stage 31-year-old stage 22-year-old stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Lamp5 gabaergic interneuron

Dorsolateral prefrontal cortex

69-year-old stage 75-year-old stage 42-year-old stage 89-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 77-year-old stage 86-year-old stage 70-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Renal medulla

72-year-old stage

Normal

Male

Slide-seqv2

Mus musculus

Obsolete inhibitory neuron Oligodendrocyte precursor cell Brain microvascular endothelial cell Obsolete excitatory neuron Astrocyte

Normal

10x 3' v2

Homo sapiens

Endothelial cell of lymphatic vessel Endothelial cell Smooth muscle cell Pericyte

Subcutaneous adipose tissue Omental fat pad

71-year-old stage 53-year-old stage 68-year-old stage 29-year-old stage 51-year-old stage 57-year-old stage 49-year-old stage 24-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 41-year-old stage 36-year-old stage 73-year-old stage

Normal

Female Male

10x 3' v3 Drop-seq

Nucleus Cell

Homo sapiens

T cell Neutrophil Granulocyte Natural killer cell Multiciliated columnar cell of tracheobronchial tree Endothelial cell Mature nk t cell Mast cell Cd8-positive, alpha-beta t cell Basal cell Ionocyte Smooth muscle cell Intermediate monocyte Connective tissue cell Plasmacytoid dendritic cell Myeloid dendritic cell Macrophage Innate lymphoid cell Regulatory t cell Plasma cell Cd4-positive, alpha-beta t cell Tracheal goblet cell B cell Serous cell of epithelium of trachea Monocyte Mucus secreting cell Fibroblast Non-classical monocyte

Trachea

61-year-old stage 56-year-old stage 59-year-old stage 67-year-old stage 45-year-old stage 60-year-old stage

Normal

Female Male

Smart-seq2 10x 3' v3

Cell

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2