Homo sapiens

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Renal medulla Cortex of kidney

65-year-old stage 53-year-old stage 54-year-old stage 56-year-old stage 50-year-old stage 72-year-old stage 64-year-old stage 62-year-old stage

Normal

Female Male

Slide-seqv2

Homo sapiens

T cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Vascular leptomeningeal cell Hippocampal interneuron Hippocampal granule cell Smooth muscle cell of the brain vasculature Ependymal cell Macrophage Mature microglial cell Pericyte Hippocampal pyramidal neuron Vascular associated smooth muscle cell Hippocampal astrocyte

Hippocampal formation

37-year-old stage 42-year-old stage 26-year-old stage 54-year-old stage 48-year-old stage 44-year-old stage 29-year-old stage 50-year-old stage 51-year-old stage 24-year-old stage 60-year-old stage 79-year-old stage 40-year-old stage

Normal

Female Male

10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

Neutrophil Granulocyte Group 3 innate lymphoid cell, human Ciliated cell Natural killer cell Lung secretory cell Pro-t cell Endothelial cell Pro-b cell Mast cell Cd8-positive, alpha-beta t cell Late pro-b cell Group 2 innate lymphoid cell Erythroid lineage cell Smooth muscle cell Plasmacytoid dendritic cell Precursor b cell Early lymphoid progenitor Megakaryocyte progenitor cell Macrophage Cd16-positive, cd56-dim natural killer cell, human Innate lymphoid cell Regulatory t cell Myelocyte Large pre-b-ii cell Mature b cell Group 1 innate lymphoid cell Cd22-positive, cd38-low small pre-b cell Common myeloid progenitor Cd4-positive, alpha-beta t cell Cd14-positive monocyte Epithelial cell of distal tubule Hematopoietic multipotent progenitor cell Megakaryocyte Alveolar adventitial fibroblast Cd14-low, cd16-positive monocyte Granulocyte monocyte progenitor cell Alveolar type 1 fibroblast cell Immature b cell Megakaryocyte-erythroid progenitor cell Fraction a pre-pro b cell Monocyte Conventional dendritic cell Fibroblast Early pro-b cell Dendritic cell Cd16-negative, cd56-bright natural killer cell, human Lung pericyte

Lung

Carnegie stage 19 21st week post-fertilization stage 13th week post-fertilization stage Carnegie stage 13 14th week post-fertilization stage 15th week post-fertilization stage 20th week post-fertilization stage 17th week post-fertilization stage 12th week post-fertilization stage 16th week post-fertilization stage Carnegie stage 20 9th week post-fertilization stage Carnegie stage 23 10th week post-fertilization stage 18th week post-fertilization stage Carnegie stage 22 22nd week post-fertilization stage Carnegie stage 16 11th week post-fertilization stage

Normal

Female Male

10x 5' transcription profiling 10x 5' v1 10x 3' v2

Cell

Homo sapiens

Endothelial cell Oligodendrocyte Lymphocyte Myeloid cell Malignant cell Pericyte Neuron Astrocyte

Glioblastoma

10x 5' v3

Homo sapiens

Central memory cd4-positive, alpha-beta t cell Cd34-positive, cd38-negative hematopoietic stem cell Effector cd8-positive, alpha-beta t cell Dendritic cell, human Igm plasma cell T-helper 2 cell Natural killer cell Erythrocyte Gamma-delta t cell Ilc1, human Mature nk t cell Hematopoietic precursor cell Erythroid progenitor cell, mammalian Myeloid lineage restricted progenitor cell Cd8-positive, alpha-beta t cell Platelet Iga plasma cell Effector memory cd4-positive, alpha-beta t cell Plasmacytoid dendritic cell Igg plasma cell Myeloid dendritic cell T-helper 22 cell Naive thymus-derived cd8-positive, alpha-beta t cell T-helper 17 cell Unswitched memory b cell Cd16-positive, cd56-dim natural killer cell, human Regulatory t cell Plasmablast Cd4-positive, alpha-beta t cell Cd14-positive monocyte Group 2 innate lymphoid cell, human Megakaryocyte Malignant cell T follicular helper cell Cd14-low, cd16-positive monocyte B cell Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell Immature b cell T-helper 1 cell Monocyte Naive b cell Dendritic cell Class switched memory b cell Cd16-negative, cd56-bright natural killer cell, human Effector memory cd8-positive, alpha-beta t cell

Blood

66-year-old stage 69-year-old stage 21-year-old stage 65-year-old stage 26-year-old stage Sixth decade stage 87-year-old stage 71-year-old stage 52-year-old stage 54-year-old stage 68-year-old stage 30-year-old stage 39-year-old stage 44-year-old stage 38-year-old stage 56-year-old stage Fifth decade stage 55-year-old stage 84-year-old stage 92-year-old stage 50-year-old stage 80-year-old stage 51-year-old stage 57-year-old stage Third decade stage 49-year-old stage Seventh decade stage 58-year-old stage 59-year-old stage 25-year-old stage 77-year-old stage 64-year-old stage 62-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 31-year-old stage Fourth decade stage 63-year-old stage Eighth decade stage 47-year-old stage 76-year-old stage 73-year-old stage 83-year-old stage Ninth decade stage 40-year-old stage

Covid-19 Normal Respiratory system disorder

Female Male

10x 3' transcription profiling

Cell

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Dorsolateral prefrontal cortex Primary visual cortex Middle temporal gyrus Primary somatosensory cortex Primary auditory cortex Primary motor cortex Anterior cingulate cortex Angular gyrus

42-year-old stage 43-year-old stage Sixth decade stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Neuron

Embryo

Theiler stage 22 Theiler stage 27 Theiler stage 24 Theiler stage 18 Theiler stage 25 Theiler stage 16 Theiler stage 17 Theiler stage 15 Theiler stage 19 Theiler stage 26 Theiler stage 20 Theiler stage 21 Theiler stage 23

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Cycling t cell Natural killer cell Endothelial cell Cycling stromal cell Mast cell Exhausted t cell Cd4-positive helper t cell Effector memory cd4-positive, alpha-beta t cell Endothelial cell of artery Capillary endothelial cell Plasmacytoid dendritic cell Igg plasma cell Myeloid dendritic cell Endothelial cell of vascular tree Cycling macrophage Macrophage Cd4-positive, cd25-positive, ccr4-positive, alpha-beta regulatory t cell Memory b cell Vein endothelial cell Malignant cell T follicular helper cell Pericyte Naive t cell Cd8-positive, alpha-beta regulatory t cell Vascular associated smooth muscle cell Myofibroblast cell Conventional dendritic cell Fibroblast Effector memory cd8-positive, alpha-beta t cell

Breast

66-year-old stage 69-year-old stage 37-year-old stage Middle aged stage 34-year-old stage 65-year-old stage 42-year-old stage 43-year-old stage Sixth decade stage 71-year-old stage 85-year-old stage 61-year-old stage 88-year-old stage 52-year-old stage 54-year-old stage 30-year-old stage 29-year-old stage 38-year-old stage Fifth decade stage 55-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 57-year-old stage 80 year-old and over stage 49-year-old stage 35-year-old stage Seventh decade stage 58-year-old stage 59-year-old stage 25-year-old stage Adult stage 67-year-old stage Late adult stage 32-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 60-79 year-old stage 36-year-old stage 63-year-old stage Eighth decade stage 47-year-old stage 79-year-old stage 73-year-old stage 83-year-old stage Prime adult stage Ninth decade stage

Invasive ductal breast carcinoma Breast cancer Estrogen-receptor positive breast cancer Breast apocrine carcinoma Invasive lobular breast carcinoma Metaplastic breast carcinoma Her2 positive breast carcinoma Breast mucinous carcinoma Triple-negative breast carcinoma Invasive tubular breast carcinoma Breast carcinoma

Female Male

10x 5' v2 10x 5' transcription profiling 10x 5' v1 10x 3' v3 10x 3' v2

Cell

Mus musculus

Glutamatergic neuron Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Astrocyte of the cerebellum Cerebellar granule cell Cerebellar golgi cell Inhibitory interneuron Ependymal cell Macrophage Microglial cell Endothelial stalk cell Interneuron Bergmann glial cell Purkinje cell Fibroblast

Cerebellum

8-week-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Central memory cd4-positive, alpha-beta t cell Gamma-delta t cell Effector memory cd4-positive, alpha-beta t cell Cd8-positive, alpha-beta memory t cell Group 3 innate lymphoid cell Naive thymus-derived cd8-positive, alpha-beta t cell Effector memory cd4-positive, alpha-beta t cell, terminally differentiated Effector memory cd8-positive, alpha-beta t cell, terminally differentiated Cd4-positive, cd25-positive, alpha-beta regulatory t cell Cd16-positive, cd56-dim natural killer cell, human Innate lymphoid cell Cd4-positive, alpha-beta memory t cell Germinal center t cell Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell Central memory cd8-positive, alpha-beta t cell Effector memory cd8-positive, alpha-beta t cell

Lung Inguinal lymph node Jejunal epithelium Epithelial lining fluid Thoracic lymph node Spleen Jejunum lamina propria Blood Bone marrow Mesenteric lymph node

75-year-old stage Sixth decade stage 68-year-old stage 48-year-old stage 56-year-old stage Fifth decade stage Third decade stage 23-year-old stage 25-year-old stage 67-year-old stage 33-year-old stage 64-year-old stage Fourth decade stage 20-year-old stage Eighth decade stage 73-year-old stage 27-year-old stage

Normal

Female Male

10x 5' v2 10x 3' v3

Cell

Homo sapiens

Natural killer cell Gamma-delta t cell Cd8-positive, alpha-beta t cell Classical monocyte Plasmacytoid dendritic cell Plasmablast Cd4-positive, alpha-beta t cell B cell Progenitor cell Conventional dendritic cell Non-classical monocyte

Blood

66-year-old stage 69-year-old stage 37-year-old stage 75-year-old stage 34-year-old stage 65-year-old stage 42-year-old stage 43-year-old stage 71-year-old stage 53-year-old stage 61-year-old stage 68-year-old stage 48-year-old stage 39-year-old stage 44-year-old stage 38-year-old stage 55-year-old stage 82-year-old stage 50-year-old stage 74-year-old stage 80 year-old and over stage 49-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 25-year-old stage Adult stage 67-year-old stage 77-year-old stage 33-year-old stage 45-year-old stage 62-year-old stage 86-year-old stage 41-year-old stage 60-year-old stage 78-year-old stage 31-year-old stage 63-year-old stage 47-year-old stage 76-year-old stage 79-year-old stage 73-year-old stage 83-year-old stage

Covid-19 Normal Respiratory system disorder

Female Male

10x 5' transcription profiling

Cell

Homo sapiens

T cell Neutrophil Stromal cell Embryonic stem cell Erythroid progenitor cell Endothelial cell Oligodendrocyte Mast cell Sertoli cell Basal cell Erythroid lineage cell Smooth muscle cell Stratified epithelial cell Epithelial cell of proximal tubule Epithelial cell Peptic cell Alternatively activated macrophage Cord blood hematopoietic stem cell Renal intercalated cell Inflammatory cell Goblet cell Macrophage Endocrine cell Myeloid cell Ventricular cardiac muscle cell Kidney loop of henle epithelial cell Enterocyte Plasma cell Acinar cell Mesothelial cell Cell of skeletal muscle B cell Professional antigen presenting cell Neuron Mesenchymal stem cell Thyroid follicular cell Monocyte Epithelial cell of exocrine pancreas Astrocyte Fibroblast Dendritic cell Primordial germ cell Pulmonary alveolar type 2 cell Chondrocyte

Pleura Embryonic stem cell Skin of body Lung Ascending colon Thymus Stomach Testis Duodenum Uterus Trachea Ureter Ileum Liver Thyroid gland Umbilical cord blood Ovary Temporal lobe Kidney Eye Intestine Placenta Vault of skull Heart Vermiform appendix Muscle organ Chorionic villus Rectum Fallopian tube Esophagus Jejunum Cerebellum Uterine cervix Brain Pancreas Adrenal gland Spleen Transverse colon Rib Omentum Artery Blood Spinal cord Bladder organ Bone marrow Adipose tissue Sigmoid colon Gallbladder Prostate gland

66-year-old stage 21-year-old stage 34-year-old stage 43-year-old stage 13th week post-fertilization stage 61-year-old stage 52-year-old stage 30-year-old stage 14th week post-fertilization stage 56-year-old stage 55-year-old stage 51-year-old stage 57-year-old stage 26th week post-fertilization stage 12th week post-fertilization stage 10th week post-fertilization stage 49-year-old stage 23-year-old stage 58-year-old stage Embryonic stage 59-year-old stage 25-year-old stage 32-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 46-year-old stage 60-year-old stage 36-year-old stage Newborn stage (0-28 days) 63-year-old stage 47-year-old stage 83-year-old stage 27-year-old stage 11th week post-fertilization stage

Normal

Female Male

Microwell-seq

Cell