Macaca fascicularis Mus musculus

Cerebellar granule cell Endothelial stalk cell Unipolar brush cell Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Cell Bergmann glial cell Interneuron Microglial cell Fibroblast Brain pericyte Ependymal cell Cerebellar golgi cell Connective tissue cell Neuron Purkinje cell Central nervous system macrophage

Normal

10x 3' v3

Mus musculus musculus

Mural cell Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Microglial cell Fibroblast Brain microvascular endothelial cell Neuron Choroid plexus epithelial cell

Normal

10x 3' transcription profiling

Homo sapiens

Cardiac neuron Cardiac endothelial cell Cardiac muscle cell Endothelial cell of lymphatic vessel Lymphocyte Macrophage Mesothelial cell Endocardial cell Mast cell Adipocyte Vascular associated smooth muscle cell Cardiac ventricle fibroblast Pericyte

Normal Dilated cardiomyopathy Hypertrophic cardiomyopathy

10x 3' v3

Homo sapiens

Common myeloid progenitor Activated cd8-positive, alpha-beta t cell Cd8-positive, alpha-beta thymocyte Erythroid progenitor cell Classical monocyte Innate lymphoid cell Cd4-positive, alpha-beta t cell Platelet Non-classical monocyte Leukocyte Macrophage Naive thymus-derived cd4-positive, alpha-beta t cell Mast cell Cd4-positive, alpha-beta thymocyte Erythroid lineage cell Neutrophil Monocyte Myeloid dendritic cell Hematopoietic cell Microglial cell Granulocyte Colon macrophage Naive thymus-derived cd8-positive, alpha-beta t cell Hematopoietic precursor cell Hematopoietic stem cell Tissue-resident macrophage Myeloid leukocyte Intermediate monocyte B cell Thymocyte Cd8-positive, alpha-beta t cell Activated cd4-positive, alpha-beta t cell Plasma cell Erythrocyte Regulatory t cell Mature nk t cell T cell Plasmacytoid dendritic cell T follicular helper cell Basophil Natural killer cell Gamma-delta t cell Langerhans cell Myeloid cell Mononuclear phagocyte

Posterior part of tongue Posterior segment of eyeball Submandibular gland Stomach smooth muscle Blood Anterior segment of eyeball Coronary artery Ileum Uterus Thymus Vasculature Mesenteric lymph node Cortex of kidney Liver Skin of abdomen Spleen Parotid gland Brown adipose tissue Testis Right ovary Bladder organ Sublingual gland Lung Inferior vena cava Small intestine Abdominal aorta Ovary Muscle of abdomen Trachea Mammary gland Kidney Muscle of pelvic diaphragm Mucosa of stomach Inguinal lymph node Endometrium Sclera Utricle of membranous labyrinth Jejunum Cardiac ventricle Aorta Muscularis mucosae of stomach Adipose tissue Crista ampullaris Subcutaneous adipose tissue Prostate gland Right cardiac atrium Cardiac atrium Skin of chest Retinal neural layer Conjunctiva Eyelid Eye Chorioretinal region Sigmoid colon Cornea Duodenum Lacrimal gland Myometrium Left coronary artery Bone marrow Thoracic aorta Endocrine pancreas Left ovary Ascending colon Stomach Exocrine pancreas Heart right ventricle Skin of body Buccal mucosa Ocular surface region Anterior part of tongue Heart Large intestine Lymph node

57-year-old stage 46-year-old stage 60-year-old stage 22-year-old stage 45-year-old stage 74-year-old stage 33-year-old stage 67-year-old stage 40-year-old stage 37-year-old stage 36-year-old stage 59-year-old stage 56-year-old stage 61-year-old stage 42-year-old stage 26-year-old stage 69-year-old stage 38-year-old stage 55-year-old stage

Normal

Female Male

Smart-seq2 10x 5' v2 10x 3' v3 Smart-seq3

Cell

Homo sapiens

Pro-b cell B-1 b cell Common myeloid progenitor Kupffer cell Pre-conventional dendritic cell Promonocyte Osteoclast Innate lymphoid cell Double-positive, alpha-beta thymocyte Large pre-b-ii cell Macrophage Mature b cell Naive thymus-derived cd4-positive, alpha-beta t cell Granulocyte monocyte progenitor cell Late pro-b cell Promyelocyte Mast cell Small pre-b-ii cell Megakaryocyte-erythroid progenitor cell Fraction a pre-pro b cell Neutrophil Monocyte Megakaryocyte Immature b cell Double negative thymocyte B-2 b cell Granulocyte Vascular associated smooth muscle cell Early lymphoid progenitor Fibroblast Naive thymus-derived cd8-positive, alpha-beta t cell Group 3 innate lymphoid cell Hematopoietic stem cell Cd8-alpha-alpha-positive, alpha-beta intraepithelial t cell Group 2 innate lymphoid cell Dendritic cell Plasma cell Erythrocyte Regulatory t cell T cell Plasmacytoid dendritic cell Common dendritic progenitor Myelocyte Natural killer cell Hematopoietic multipotent progenitor cell Langerhans cell

Thymus Mesenteric lymph node Liver Spleen Kidney Bone marrow Gut wall Yolk sac Skin of body

9th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 22 11th week post-fertilization stage 17th week post-fertilization stage 15th week post-fertilization stage Carnegie stage 19 Carnegie stage 13 14th week post-fertilization stage 16th week post-fertilization stage Carnegie stage 23 Carnegie stage 20

Normal

Female Male

10x 5' v1 10x 3' v2

Cell

Homo sapiens

Bronchus fibroblast of lung Myofibroblast cell Acinar cell Cd1c-positive myeloid dendritic cell Pulmonary alveolar type 1 cell Capillary endothelial cell Classical monocyte Endothelial cell of lymphatic vessel Epithelial cell of lower respiratory tract Cd4-positive, alpha-beta t cell Pulmonary alveolar type 2 cell Club cell Pulmonary neuroendocrine cell Non-classical monocyte Ionocyte Mesothelial cell Alveolar macrophage Brush cell of tracheobronchial tree Alveolar type 1 fibroblast cell Stromal cell Mast cell Tracheobronchial smooth muscle cell Multiciliated columnar cell of tracheobronchial tree Pulmonary artery endothelial cell Tracheobronchial serous cell Vein endothelial cell Nasal mucosa goblet cell Serous secreting cell Respiratory tract hillock cell Conventional dendritic cell Fibroblast Tracheobronchial goblet cell Hematopoietic stem cell Multiciliated epithelial cell B cell Cd8-positive, alpha-beta t cell Lung macrophage Lung pericyte Bronchial goblet cell Dendritic cell Plasma cell Pulmonary alveolar epithelial cell T cell Plasmacytoid dendritic cell Mucus secreting cell Alveolar adventitial fibroblast Smooth muscle cell Respiratory basal cell Natural killer cell Elicited macrophage

Nose Lung parenchyma Respiratory airway

66-year-old stage 18-year-old stage Fourth decade stage 21-year-old stage 57-year-old stage 76-year-old stage 62-year-old stage 46-year-old stage 52-year-old stage 22-year-old stage 44-year-old stage 64-year-old stage 25-year-old stage 33-year-old stage 40-year-old stage 75-year-old stage 27-year-old stage 23-year-old stage 37-year-old stage 71-year-old stage 36-year-old stage 63-year-old stage 59-year-old stage 54-year-old stage Fifth decade stage 47-year-old stage 31-year-old stage 56-year-old stage 58-year-old stage 68-year-old stage 61-year-old stage 15-year-old stage 34-year-old stage 51-year-old stage 49-year-old stage 42-year-old stage 35-year-old stage 53-year-old stage 10-year-old stage 30-year-old stage 24-year-old stage Seventh decade stage 26-year-old stage 69-year-old stage 29-year-old stage 38-year-old stage 41-year-old stage 55-year-old stage Sixth decade stage

Normal

Female Male

10x 5' v2 10x 5' v1 10x 3' v3 10x 3' v1 10x 3' v2

Cell

Homo sapiens

Myofibroblast cell Circulating fibrocyte Pulmonary alveolar type 1 cell Capillary endothelial cell Endothelial cell of lymphatic vessel Pulmonary alveolar type 2 cell Macrophage Mast cell Tracheobronchial smooth muscle cell Basal cell Monocyte Vein endothelial cell Nkp46-positive innate lymphoid cell, human Fibroblast Multiciliated epithelial cell B cell Dendritic cell T cell Secretory cell Lung secretory cell Endothelial cell of artery

Nose Lung parenchyma Respiratory airway

66-year-old stage 18-year-old stage 21-year-old stage 32-year-old stage 50-year-old stage 57-year-old stage 76-year-old stage 62-year-old stage 46-year-old stage 52-year-old stage 22-year-old stage 44-year-old stage 64-year-old stage 25-year-old stage 33-year-old stage 67-year-old stage 40-year-old stage 75-year-old stage 27-year-old stage 23-year-old stage 37-year-old stage 71-year-old stage 36-year-old stage 63-year-old stage 59-year-old stage 54-year-old stage 47-year-old stage 31-year-old stage 56-year-old stage 58-year-old stage 68-year-old stage 61-year-old stage 15-year-old stage 34-year-old stage 49-year-old stage 42-year-old stage 35-year-old stage 53-year-old stage 10-year-old stage 30-year-old stage 24-year-old stage 26-year-old stage 69-year-old stage 29-year-old stage 38-year-old stage 41-year-old stage 55-year-old stage

Normal

Female Male

10x 5' v2 10x 5' v1 10x 3' v3 10x 3' v1 10x 3' v2

Cell

Homo sapiens

Schwann cell Capillary endothelial cell Endothelial cell of lymphatic vessel Lymphocyte Macrophage Myelinating schwann cell Mast cell Epithelial cell Endothelial cell of venule Monocyte Keratocyte Fibroblast Pericyte Corneal endothelial cell B cell Conjunctival epithelial cell Smooth muscle cell Endothelial cell of artery Melanocyte

Corneal epithelium Corneal endothelium Sclera Tunica fibrosa of eyeball Cornea Corneo-scleral junction Substantia propria of cornea Ocular surface region

16-year-old stage 70-year-old stage 77-year-old stage 32-year-old stage 86-year-old stage 62-year-old stage 22-year-old stage 48-year-old stage 64-year-old stage 45-year-old stage 25-year-old stage 74-year-old stage 33-year-old stage 65-year-old stage 67-year-old stage 1-year-old stage 2-year-old stage Postnatal stage Eighth decade stage 75-year-old stage 27-year-old stage 61-year-old stage 34-year-old stage 51-year-old stage 53-year-old stage 10-year-old stage 72-year-old stage 13-year-old stage 84-year-old stage 39-year-old stage Newborn stage (0-28 days) 69-year-old stage 43-year-old stage 90 year-old and over stage 87-year-old stage 41-year-old stage 55-year-old stage 83-year-old stage 11-year-old stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Gabaergic amacrine cell Starburst amacrine cell Amacrine cell Glycinergic amacrine cell

Macula lutea Peripheral region of retina Fovea centralis Macula lutea proper

80-year-old stage 85-year-old stage 82-year-old stage 66-year-old stage 16-year-old stage 70-year-old stage 18-year-old stage 77-year-old stage 21-year-old stage 32-year-old stage 50-year-old stage 86-year-old stage 76-year-old stage 62-year-old stage Prime adult stage 46-year-old stage 52-year-old stage 60-year-old stage 60-79 year-old stage 80 year-old and over stage 64-year-old stage 25-year-old stage 74-year-old stage 65-year-old stage 67-year-old stage Eighth decade stage 75-year-old stage 27-year-old stage 71-year-old stage 78-year-old stage 63-year-old stage 47-year-old stage 58-year-old stage 68-year-old stage 15-year-old stage 34-year-old stage 53-year-old stage 10-year-old stage 17-year-old stage 72-year-old stage 73-year-old stage 30-year-old stage 24-year-old stage 3-year-old stage 88-year-old stage 84-year-old stage 69-year-old stage 43-year-old stage 90 year-old and over stage Late adult stage 41-year-old stage 81-year-old stage 83-year-old stage 11-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Drosophila melanogaster

Adult malpighian tubule bar-shaped cell of initial segment Eo sensory organ accessory cell Multidendritic neuron Adult olfactory receptor neuron gr21a/63a Lamina monopolar neuron l4 Early elongation stage spermatid Transmedullary y neuron tmy5a Adult olfactory receptor neuron or67d Adult heart ventral longitudinal muscle cell Muscle cell Stalk follicle cell Medulla intrinsic neuron mi15 Adult alary muscle cell Mechanosensory neuron of leg chordotonal organ Medulla intrinsic neuron mi1 Gustatory receptor neuron Proximal medullary amacrine neuron pm4 Distal medullary amacrine neuron dm9 Midgut large flat cell Columnar neuron t1 Transmedullary y neuron tmy4 Transmedullary neuron tm9 Tendon cell Adult olfactory receptor neuron ir75d Leg muscle motor neuron Enteroblast Distal medullary amacrine neuron dm10 Auditory sensory neuron Proximal medullary amacrine neuron pm2 Ensheathing glial cell Adult astrocyte-like glial cell Escort cell Lobula columnar neuron lc17 Lobula columnar neuron lc12 Enteroendocrine cell Adult olfactory receptor neuron or65 Kenyon cell Early-mid elongation-stage spermatid Ocellar retinula cell Spermatocyte Transmedullary neuron tm3 Adult glial cell Centrifugal neuron c3 Adult brain cell body glial cell Germline cell Leg taste bristle chemosensory neuron T2a neuron Adult optic chiasma glial cell Mechanosensory neuron Male accessory gland secondary cell Cns surface glial cell Spermatid T2 neuron Medulla intrinsic neuron mi9 Labral sense organ mechanosensory neuron Lamina wide-field 1 neuron Cone cell Distal medullary amacrine neuron dm11 Transmedullary neuron tm20 Olfactory receptor neuron Follicle cell Transmedullary y neuron tmy8 Lamina monopolar neuron l3 Pigment cell Enterocyte of anterior adult midgut epithelium Adult malpighian tubule principal cell of initial segment Spermatogonium Lamina monopolar neuron l1 Epithelial cell Chordotonal neuron Lamina monopolar neuron l2 Transmedullary neuron tm2 Dorsal appendage forming follicle cell Lamina monopolar neuron l5 Medulla intrinsic neuron mi4 Sensory neuron Adult somatic muscle cell of head Cardial cell Adult malpighian tubule principal cell Nociceptive neuron Copper cell Eye photoreceptor cell Gustatory receptor neuron of the labellum Distal medullary amacrine neuron dm3 Embryonic/larval crystal cell Adult brain perineurial glial cell Transmedullary neuron tm5c Outer photoreceptor cell Adult abdominal pericardial cell Optic-lobe-associated cortex glial cell Adult midgut enterocyte Adult neuron Adult olfactory receptor neuron or92a Gamma kenyon cell Indirect flight muscle cell Antennal lobe projection neuron Photoreceptor cell r7 Adult olfactory receptor neuron or47b Alpha'/beta' kenyon cell Hemocyte Distal medullary amacrine neuron dm8a Ovarian sheath muscle cell Adult renal stem cell Dopaminergic neuron Stretch follicle cell Enterocyte of posterior adult midgut epithelium Centrifugal neuron c2 Intestinal stem cell Cell body glial cell Photoreceptor cell r8 Adult dopaminergic pam neuron Adult malpighian tubule stellate cell of main segment Lamina wide-field 2 neuron T3 neuron Adult olfactory receptor neuron or88a Transmedullary neuron tm1 Adult differentiating enterocyte Maxillary palp olfactory receptor neuron Subperineurial glial cell Visceral muscle cell Adult lobula astrocyte-like glial cell Lobula columnar neuron lc10 Distal medullary amacrine neuron dm12 Transmedullary neuron tm4 Adult oenocyte Polar follicle cell Adult malpighian tubule principal cell of lower ureter Alpha/beta kenyon cell Adult malpighian tubule principal cell of lower segment Tormogen cell Male accessory gland main cell Johnston organ neuron Adult olfactory receptor neuron or13a Transmedullary y neuron tmy14 Adult enterocyte Mid-late elongation-stage spermatid

Oenocyte Ovary Antenna Leg Wing Proboscis Testis Trachea Maxillary palp Male reproductive gland Fat body Haltere Head Gut Malpighian tubule Heart Body wall

Day 1 of adulthood Day 3 of adulthood Day 5 of adulthood Day 2 of adulthood

Normal

Female Male Mixed sex

10x 3' v3

Homo sapiens

Schwann cell Classical monocyte Innate lymphoid cell Cytotoxic t cell Non-classical monocyte Endothelial cell of arteriole Helper t cell Macrophage Myelinating schwann cell Mast cell Endothelial cell of venule Non-myelinating schwann cell Megakaryocyte Vein endothelial cell Vascular associated smooth muscle cell Fibroblast Pericyte B cell Dendritic cell Plasma cell T cell Plasmacytoid dendritic cell Fenestrated endothelial cell Retinal pigment epithelial cell Smooth muscle cell Natural killer cell Endothelial cell of artery Melanocyte

Chorioretinal region

82-year-old stage 16-year-old stage 77-year-old stage 21-year-old stage 32-year-old stage 50-year-old stage 86-year-old stage 62-year-old stage 46-year-old stage 60-year-old stage 64-year-old stage 25-year-old stage 65-year-old stage 27-year-old stage 71-year-old stage 63-year-old stage 47-year-old stage 58-year-old stage 68-year-old stage 34-year-old stage 53-year-old stage 10-year-old stage 17-year-old stage 72-year-old stage 30-year-old stage Newborn stage (0-28 days) 69-year-old stage 43-year-old stage 90 year-old and over stage 81-year-old stage 11-year-old stage

Normal

Female Male

10x 5' v2 10x 3' v3

Nucleus

Homo sapiens

Neuron

Upper layers of the cortex Dorsal plus ventral thalamus Head Entorhinal cortex Cerebral subcortex Caudate-putamen Hippocampal formation Hypothalamus Diencephalon Forebrain Cerebellum Telencephalon Choroid plexus epithelium Cerebellar peduncular complex Frontal cortex Brain Striatum Pons Midbrain Lower layers of the cortex Medulla oblongata Hindbrain Cortex Midbrain tectum Basal forebrain Occipital cortex Metencephalon

9th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 22 11th week post-fertilization stage 15th week post-fertilization stage 14th week post-fertilization stage Carnegie stage 15 Carnegie stage 20 Carnegie stage 18 Carnegie stage 16

Normal

10x 3' v3 10x 3' v2

Cell