Homo sapiens

Natural killer cell Endothelial cell of lymphatic vessel Follicular dendritic cell Endothelial cell Cd8-positive, alpha-beta t cell Smooth muscle cell Plasmacytoid dendritic cell Adipocyte Macrophage Regulatory t cell Monocyte-derived dendritic cell Cd4-positive, alpha-beta t cell T follicular helper cell Pericyte Monocyte Conventional dendritic cell Fibroblast Dendritic cell

Lymph node

Sixth decade stage Fifth decade stage Third decade stage Seventh decade stage Fourth decade stage Eighth decade stage Tenth decade stage Ninth decade stage

B-cell non-hodgkin lymphoma Normal

Female Male

10x multiome

Nucleus

Macaca fascicularis Mus musculus

Central nervous system macrophage Cell Oligodendrocyte precursor cell Oligodendrocyte Cerebellar granule cell Cerebellar golgi cell Connective tissue cell Brain pericyte Ependymal cell Microglial cell Endothelial stalk cell Interneuron Bergmann glial cell Neuron Purkinje cell Astrocyte Unipolar brush cell Fibroblast

Normal

10x 3' v3

Mus musculus musculus

Oligodendrocyte precursor cell Oligodendrocyte Microglial cell Brain microvascular endothelial cell Mural cell Choroid plexus epithelial cell Neuron Astrocyte Fibroblast

Normal

10x 3' transcription profiling

Homo sapiens

Endocardial cell Cardiac endothelial cell Endothelial cell of lymphatic vessel Mast cell Cardiac neuron Lymphocyte Adipocyte Macrophage Cardiac ventricle fibroblast Mesothelial cell Cardiac muscle cell Pericyte Vascular associated smooth muscle cell

Dilated cardiomyopathy Normal Hypertrophic cardiomyopathy

10x 3' v3

Homo sapiens

T cell Neutrophil Granulocyte Natural killer cell Erythroid progenitor cell Erythrocyte Gamma-delta t cell Tissue-resident macrophage Activated cd4-positive, alpha-beta t cell Mature nk t cell Hematopoietic precursor cell Mast cell Cd8-positive, alpha-beta t cell Platelet Colon macrophage Erythroid lineage cell Leukocyte Classical monocyte Intermediate monocyte Plasmacytoid dendritic cell Myeloid dendritic cell Naive thymus-derived cd8-positive, alpha-beta t cell Thymocyte Macrophage Microglial cell Innate lymphoid cell Regulatory t cell Activated cd8-positive, alpha-beta t cell Myeloid cell Hematopoietic stem cell Common myeloid progenitor Plasma cell Cd4-positive, alpha-beta t cell Cd8-positive, alpha-beta thymocyte Cd4-positive, alpha-beta thymocyte Langerhans cell T follicular helper cell B cell Naive thymus-derived cd4-positive, alpha-beta t cell Myeloid leukocyte Monocyte Basophil Hematopoietic cell Non-classical monocyte Mononuclear phagocyte

Abdominal aorta Adipose tissue Anterior part of tongue Anterior segment of eyeball Aorta Ascending colon Bladder organ Blood Bone marrow Brown adipose tissue Buccal mucosa Cardiac atrium Cardiac ventricle Chorioretinal region Conjunctiva Cornea Coronary artery Cortex of kidney Crista ampullaris Duodenum Endocrine pancreas Endometrium Exocrine pancreas Eye Eyelid Heart Heart right ventricle Ileum Inferior vena cava Inguinal lymph node Jejunum Kidney Lacrimal gland Large intestine Left coronary artery Left ovary Liver Lung Lymph node Mammary gland Mesenteric lymph node Mucosa of stomach Muscle of abdomen Muscle of pelvic diaphragm Muscularis mucosae of stomach Myometrium Ocular surface region Ovary Parotid gland Posterior part of tongue Posterior segment of eyeball Prostate gland Retinal neural layer Right cardiac atrium Right ovary Sclera Sigmoid colon Skin of abdomen Skin of body Skin of chest Small intestine Spleen Stomach Stomach smooth muscle Subcutaneous adipose tissue Sublingual gland Submandibular gland Testis Thoracic aorta Thymus Trachea Uterus Utricle of membranous labyrinth Vasculature

69-year-old stage 37-year-old stage 42-year-old stage 26-year-old stage 61-year-old stage 38-year-old stage 56-year-old stage 55-year-old stage 57-year-old stage 74-year-old stage 59-year-old stage 67-year-old stage 33-year-old stage 45-year-old stage 46-year-old stage 60-year-old stage 36-year-old stage 22-year-old stage 40-year-old stage

Normal

Female Male

10x 5' v2 Smart-seq3 Smart-seq2 10x 3' v3

Cell

Homo sapiens

T cell B-2 b cell Neutrophil Granulocyte Natural killer cell Erythrocyte Small pre-b-ii cell Cd8-alpha-alpha-positive, alpha-beta intraepithelial t cell B-1 b cell Kupffer cell Pro-b cell Mast cell Late pro-b cell Group 2 innate lymphoid cell Double-positive, alpha-beta thymocyte Pre-conventional dendritic cell Plasmacytoid dendritic cell Early lymphoid progenitor Common dendritic progenitor Group 3 innate lymphoid cell Naive thymus-derived cd8-positive, alpha-beta t cell Macrophage Innate lymphoid cell Regulatory t cell Myelocyte Large pre-b-ii cell Mature b cell Promonocyte Hematopoietic stem cell Common myeloid progenitor Plasma cell Hematopoietic multipotent progenitor cell Megakaryocyte Langerhans cell Granulocyte monocyte progenitor cell Naive thymus-derived cd4-positive, alpha-beta t cell Promyelocyte Immature b cell Megakaryocyte-erythroid progenitor cell Fraction a pre-pro b cell Monocyte Vascular associated smooth muscle cell Double negative thymocyte Fibroblast Osteoclast Dendritic cell

Bone marrow Gut wall Kidney Liver Mesenteric lymph node Skin of body Spleen Thymus Yolk sac

Carnegie stage 19 13th week post-fertilization stage Carnegie stage 13 14th week post-fertilization stage 15th week post-fertilization stage 17th week post-fertilization stage 12th week post-fertilization stage 16th week post-fertilization stage Carnegie stage 20 9th week post-fertilization stage Carnegie stage 23 10th week post-fertilization stage Carnegie stage 22 11th week post-fertilization stage

Normal

Female Male

10x 5' v1 10x 3' v2

Cell

Homo sapiens

T cell Tracheobronchial smooth muscle cell Nasal mucosa goblet cell Club cell Cd1c-positive myeloid dendritic cell Stromal cell Tracheobronchial serous cell Natural killer cell Endothelial cell of lymphatic vessel Pulmonary alveolar epithelial cell Bronchial goblet cell Multiciliated columnar cell of tracheobronchial tree Mast cell Cd8-positive, alpha-beta t cell Pulmonary neuroendocrine cell Serous secreting cell Capillary endothelial cell Classical monocyte Ionocyte Smooth muscle cell Plasmacytoid dendritic cell Bronchus fibroblast of lung Lung macrophage Brush cell of tracheobronchial tree Respiratory tract hillock cell Pulmonary alveolar type 1 cell Respiratory basal cell Hematopoietic stem cell Alveolar macrophage Plasma cell Cd4-positive, alpha-beta t cell Vein endothelial cell Alveolar adventitial fibroblast Acinar cell Mesothelial cell Epithelial cell of lower respiratory tract B cell Alveolar type 1 fibroblast cell Pulmonary artery endothelial cell Mucus secreting cell Elicited macrophage Myofibroblast cell Multiciliated epithelial cell Conventional dendritic cell Fibroblast Dendritic cell Pulmonary alveolar type 2 cell Lung pericyte Tracheobronchial goblet cell Non-classical monocyte

Lung parenchyma Nose Respiratory airway

66-year-old stage 69-year-old stage 37-year-old stage 75-year-old stage 21-year-old stage 34-year-old stage 42-year-old stage 26-year-old stage Sixth decade stage 71-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 54-year-old stage 68-year-old stage 30-year-old stage 44-year-old stage 29-year-old stage 38-year-old stage 56-year-old stage Fifth decade stage 55-year-old stage 15-year-old stage 51-year-old stage 57-year-old stage 49-year-old stage 24-year-old stage 23-year-old stage 35-year-old stage Seventh decade stage 58-year-old stage 59-year-old stage 25-year-old stage 33-year-old stage 64-year-old stage 62-year-old stage 41-year-old stage 46-year-old stage 18-year-old stage 31-year-old stage 36-year-old stage Fourth decade stage 22-year-old stage 63-year-old stage 47-year-old stage 76-year-old stage 27-year-old stage 40-year-old stage 10-year-old stage

Normal

Female Male

10x 3' v1 10x 5' v2 10x 5' v1 10x 3' v3 10x 3' v2

Cell

Homo sapiens

T cell Tracheobronchial smooth muscle cell Endothelial cell of lymphatic vessel Lung secretory cell Secretory cell Mast cell Nkp46-positive innate lymphoid cell, human Basal cell Endothelial cell of artery Capillary endothelial cell Macrophage Pulmonary alveolar type 1 cell Vein endothelial cell B cell Circulating fibrocyte Monocyte Myofibroblast cell Multiciliated epithelial cell Fibroblast Dendritic cell Pulmonary alveolar type 2 cell

Lung parenchyma Nose Respiratory airway

66-year-old stage 69-year-old stage 37-year-old stage 75-year-old stage 21-year-old stage 34-year-old stage 42-year-old stage 26-year-old stage 71-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 54-year-old stage 68-year-old stage 30-year-old stage 44-year-old stage 29-year-old stage 38-year-old stage 56-year-old stage 55-year-old stage 15-year-old stage 50-year-old stage 57-year-old stage 49-year-old stage 24-year-old stage 23-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 25-year-old stage 67-year-old stage 32-year-old stage 33-year-old stage 64-year-old stage 62-year-old stage 41-year-old stage 46-year-old stage 18-year-old stage 31-year-old stage 36-year-old stage 22-year-old stage 63-year-old stage 47-year-old stage 76-year-old stage 27-year-old stage 40-year-old stage 10-year-old stage

Normal

Female Male

10x 3' v1 10x 5' v2 10x 5' v1 10x 3' v3 10x 3' v2

Cell

Homo sapiens

Endothelial cell of venule Endothelial cell of lymphatic vessel Conjunctival epithelial cell Mast cell Endothelial cell of artery Capillary endothelial cell Schwann cell Melanocyte Smooth muscle cell Epithelial cell Lymphocyte Macrophage B cell Pericyte Monocyte Fibroblast Myelinating schwann cell Keratocyte Corneal endothelial cell

Cornea Corneal endothelium Corneal epithelium Corneo-scleral junction Ocular surface region Sclera Substantia propria of cornea Tunica fibrosa of eyeball

69-year-old stage 75-year-old stage 13-year-old stage 34-year-old stage 65-year-old stage 43-year-old stage 87-year-old stage 53-year-old stage 61-year-old stage 2-year-old stage 48-year-old stage 39-year-old stage 55-year-old stage 84-year-old stage 51-year-old stage 72-year-old stage 74-year-old stage 16-year-old stage 25-year-old stage 67-year-old stage 90 year-old and over stage 32-year-old stage 77-year-old stage 33-year-old stage 64-year-old stage Postnatal stage 45-year-old stage 62-year-old stage 86-year-old stage 41-year-old stage 70-year-old stage 1-year-old stage 22-year-old stage Newborn stage (0-28 days) Eighth decade stage 83-year-old stage 11-year-old stage 27-year-old stage 10-year-old stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Gabaergic amacrine cell Glycinergic amacrine cell Amacrine cell Starburst amacrine cell

Fovea centralis Macula lutea Macula lutea proper Peripheral region of retina

66-year-old stage 69-year-old stage 75-year-old stage 21-year-old stage 34-year-old stage 65-year-old stage 43-year-old stage 71-year-old stage 85-year-old stage 53-year-old stage 88-year-old stage 52-year-old stage 68-year-old stage 30-year-old stage 17-year-old stage 84-year-old stage 15-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 74-year-old stage 80 year-old and over stage 24-year-old stage 16-year-old stage 58-year-old stage 25-year-old stage 67-year-old stage Late adult stage 90 year-old and over stage 3-year-old stage 32-year-old stage 77-year-old stage 64-year-old stage 62-year-old stage 86-year-old stage 41-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 78-year-old stage 18-year-old stage 60-79 year-old stage 63-year-old stage Eighth decade stage 47-year-old stage 76-year-old stage 73-year-old stage 83-year-old stage Prime adult stage 11-year-old stage 27-year-old stage 10-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Gabaergic amacrine cell Glycinergic amacrine cell Amacrine cell Starburst amacrine cell

Normal

10x 3' v3

Drosophila melanogaster

Adult somatic muscle cell of head Outer photoreceptor cell Optic-lobe-associated cortex glial cell Mechanosensory neuron of leg chordotonal organ Transmedullary y neuron tmy8 T2 neuron Adult abdominal pericardial cell Transmedullary y neuron tmy4 Nociceptive neuron Gamma kenyon cell Indirect flight muscle cell Transmedullary neuron tm3 Subperineurial glial cell Alpha/beta kenyon cell Transmedullary neuron tm1 Proximal medullary amacrine neuron pm2 Adult olfactory receptor neuron or88a Cardial cell Adult malpighian tubule principal cell of initial segment Alpha'/beta' kenyon cell Photoreceptor cell r7 Adult malpighian tubule principal cell Adult olfactory receptor neuron or67d Lamina wide-field 2 neuron Adult olfactory receptor neuron or47b Lobula columnar neuron lc10 Distal medullary amacrine neuron dm10 T3 neuron Adult optic chiasma glial cell Visceral muscle cell Eo sensory organ accessory cell Polar follicle cell Midgut large flat cell Adult renal stem cell Centrifugal neuron c2 Lamina monopolar neuron l4 Leg taste bristle chemosensory neuron Photoreceptor cell r8 Gustatory receptor neuron Hemocyte Dorsal appendage forming follicle cell Ocellar retinula cell Enteroendocrine cell Maxillary palp olfactory receptor neuron Proximal medullary amacrine neuron pm4 Follicle cell Spermatid Adult enterocyte Antennal lobe projection neuron Eye photoreceptor cell Stretch follicle cell Adult midgut enterocyte Copper cell Chordotonal neuron Johnston organ neuron Lobula columnar neuron lc12 Spermatogonium Epithelial cell Ensheathing glial cell Germline cell Adult alary muscle cell Muscle cell Enterocyte of anterior adult midgut epithelium Transmedullary neuron tm2 Adult malpighian tubule principal cell of lower segment Transmedullary neuron tm9 Leg muscle motor neuron Transmedullary neuron tm20 Transmedullary neuron tm5c Lamina monopolar neuron l2 Distal medullary amacrine neuron dm8a Multidendritic neuron Escort cell Intestinal stem cell Distal medullary amacrine neuron dm9 Lamina wide-field 1 neuron Adult malpighian tubule principal cell of lower ureter Distal medullary amacrine neuron dm12 Adult glial cell Medulla intrinsic neuron mi4 Adult neuron Early elongation stage spermatid Cns surface glial cell Ovarian sheath muscle cell Lamina monopolar neuron l3 Embryonic/larval crystal cell Mechanosensory neuron Auditory sensory neuron Distal medullary amacrine neuron dm11 Tormogen cell Columnar neuron t1 Adult olfactory receptor neuron gr21a/63a Transmedullary y neuron tmy14 Kenyon cell Sensory neuron Mid-late elongation-stage spermatid Adult brain perineurial glial cell Enterocyte of posterior adult midgut epithelium Centrifugal neuron c3 Olfactory receptor neuron Adult oenocyte Adult astrocyte-like glial cell T2a neuron Male accessory gland secondary cell Distal medullary amacrine neuron dm3 Adult olfactory receptor neuron ir75d Medulla intrinsic neuron mi15 Labral sense organ mechanosensory neuron Transmedullary y neuron tmy5a Adult malpighian tubule bar-shaped cell of initial segment Dopaminergic neuron Tendon cell Spermatocyte Gustatory receptor neuron of the labellum Enteroblast Adult dopaminergic pam neuron Medulla intrinsic neuron mi1 Adult lobula astrocyte-like glial cell Medulla intrinsic neuron mi9 Pigment cell Male accessory gland main cell Early-mid elongation-stage spermatid Stalk follicle cell Transmedullary neuron tm4 Adult brain cell body glial cell Adult olfactory receptor neuron or92a Lamina monopolar neuron l5 Cell body glial cell Cone cell Adult differentiating enterocyte Lamina monopolar neuron l1 Adult heart ventral longitudinal muscle cell Adult olfactory receptor neuron or65 Adult malpighian tubule stellate cell of main segment Lobula columnar neuron lc17 Adult olfactory receptor neuron or13a

Antenna Heart Oenocyte Gut Malpighian tubule Proboscis Maxillary palp Haltere Head Leg Ovary Testis Trachea Wing Fat body Body wall Male reproductive gland

Day 3 of adulthood Day 5 of adulthood Day 2 of adulthood Day 1 of adulthood

Normal

Mixed sex Female Male

10x 3' v3