Homo sapiens

Myofibroblast cell Granzyme k-associated cd8 t cell Pulmonary alveolar type 1 cell Endothelial cell of respiratory system lymphatic vessel Classical monocyte Pulmonary alveolar type 2 cell Pulmonary neuroendocrine cell Endothelial cell of arteriole Helper t cell Macrophage Vein endothelial cell of respiratory system Alveolar macrophage Alveolar type 1 fibroblast cell Mast cell Basal cell Adventitial fibroblast Epithelial cell of lung Lung interstitial macrophage Monocyte Myeloid dendritic cell, human Hematopoietic cell Cd8-positive, alpha-beta cytotoxic t cell Conventional dendritic cell Pericyte Mesothelial cell of pleura B cell Plasma cell Pulmonary capillary endothelial cell Plasmacytoid dendritic cell Smooth muscle cell Lung secretory cell Natural killer cell Ciliated cell

Lung

66-year-old stage 19-year-old stage 70-year-old stage 50-year-old stage 57-year-old stage 62-year-old stage 46-year-old stage 52-year-old stage 60-year-old stage 44-year-old stage 64-year-old stage 45-year-old stage 25-year-old stage 74-year-old stage 65-year-old stage 67-year-old stage 40-year-old stage 27-year-old stage 71-year-old stage 36-year-old stage 63-year-old stage 59-year-old stage 54-year-old stage 47-year-old stage 31-year-old stage 56-year-old stage 58-year-old stage 68-year-old stage 61-year-old stage 15-year-old stage 34-year-old stage 49-year-old stage 35-year-old stage 53-year-old stage 17-year-old stage 72-year-old stage 73-year-old stage 30-year-old stage 69-year-old stage 43-year-old stage 29-year-old stage 38-year-old stage 41-year-old stage 55-year-old stage

Normal Anthracosis Lymphoid interstitial pneumonia Pulmonary sarcoidosis Hypersensitivity pneumonitis Interstitial lung disease Non-specific interstitial pneumonia

Female Male

10x 5' v2 10x 5' v1

Cell

Homo sapiens

Naive b cell Cd4-positive, alpha-beta t cell Platelet Lymphocyte Cd14-positive, cd16-positive monocyte Cd14-positive monocyte Dendritic cell, human Naive thymus-derived cd8-positive, alpha-beta t cell Cd8-positive, alpha-beta t cell Plasma cell Memory b cell Plasmacytoid dendritic cell Natural killer cell

Blood

19-year-old stage 18-year-old stage 21-year-old stage 32-year-old stage 50-year-old stage 57-year-old stage 46-year-old stage 52-year-old stage 60-year-old stage 22-year-old stage 44-year-old stage 48-year-old stage 45-year-old stage 25-year-old stage 33-year-old stage 40-year-old stage 27-year-old stage 23-year-old stage 37-year-old stage 28-year-old stage 36-year-old stage 54-year-old stage 20-year-old stage 47-year-old stage 31-year-old stage 58-year-old stage 34-year-old stage 51-year-old stage 49-year-old stage 42-year-old stage 35-year-old stage 53-year-old stage 30-year-old stage 24-year-old stage 26-year-old stage 39-year-old stage 43-year-old stage 29-year-old stage 38-year-old stage 41-year-old stage 55-year-old stage

Normal

Female Male

10x 5' v2

Cell

Homo sapiens

Cerebral cortex gabaergic interneuron Cerebral cortex endothelial cell Glutamatergic neuron Oligodendrocyte precursor cell Progenitor cell Microglial cell Blood vessel endothelial cell Forebrain radial glial cell Cajal-retzius cell

Primary somatosensory cortex Temporal cortex Parietal cortex Primary motor cortex Primary visual cortex Prefrontal cortex

19th week post-fertilization stage 20th week post-fertilization stage 17th week post-fertilization stage 22nd week post-fertilization stage 25th week post-fertilization stage 14th week post-fertilization stage 16th week post-fertilization stage 18th week post-fertilization stage

Normal

10x 3' v2

Cell

Homo sapiens

Be cell Naive b cell Transitional stage b cell Plasma cell Memory b cell

Blood

80-year-old stage 85-year-old stage 82-year-old stage 66-year-old stage 79-year-old stage 70-year-old stage 77-year-old stage 50-year-old stage 86-year-old stage 57-year-old stage 76-year-old stage 62-year-old stage 46-year-old stage 52-year-old stage 60-year-old stage 80 year-old and over stage 44-year-old stage 48-year-old stage 64-year-old stage 89-year-old stage 45-year-old stage 74-year-old stage 65-year-old stage 67-year-old stage 40-year-old stage 75-year-old stage 71-year-old stage 78-year-old stage 63-year-old stage 59-year-old stage 54-year-old stage 47-year-old stage 56-year-old stage 58-year-old stage 68-year-old stage 61-year-old stage 51-year-old stage 49-year-old stage 42-year-old stage 53-year-old stage 72-year-old stage 73-year-old stage 88-year-old stage 84-year-old stage 69-year-old stage 43-year-old stage 87-year-old stage 41-year-old stage 81-year-old stage 55-year-old stage 83-year-old stage

Normal Cytomegalovirus infection

Female Male

10x gene expression flex

Cell

Homo sapiens

Neuron

Inferior frontal gyrus Middle temporal gyrus Putamen Brodmann (1909) area 24 Posterior parahippocampal gyrus Anterior olfactory nucleus Brodmann (1909) area 38 Pretectal region Subicular complex Gray matter of midbrain Brodmann (1909) area 14 Brodmann (1909) area 19 Inferior temporal gyrus Hypothalamus Brodmann (1909) area 32 Dentate gyrus of hippocampal formation Lateral geniculate body Bed nucleus of stria terminalis Brodmann (1909) area 13 Primary somatosensory cortex Medial geniculate body Preoptic area Substantia innominata Perirhinal cortex Body of caudate nucleus Extrastriate cortex Lateral nuclear group of thalamus Dorsal tegmental nucleus Brodmann (1909) area 23 Epithalamus Substantia nigra Central amygdaloid nucleus Granular insular cortex Agranular insular cortex Globus pallidus Basolateral amygdaloid nuclear complex Parabrachial nucleus Ventral anterior nucleus of thalamus Nucleus of dorsal thalamus Anterior cortical amygdaloid nucleus Anterior nuclear group Brodmann (1909) area 43 Primary auditory cortex Medial entorhinal cortex Red nucleus Corticomedial nuclear complex Lateral posterior nucleus of thalamus Brodmann (1909) area 46 Nucleus of medulla oblongata Supraoptic nucleus Temporal fusiform gyrus Lateral entorhinal cortex Brodmann (1909) area 25 Midbrain nucleus Primary motor cortex Pulvinar nucleus Pontine tegmentum Primary visual cortex Subthalamic nucleus Spinal cord Superior parietal cortex Hippocampal field Inferior olivary complex Piriform cortex Lateral amygdaloid nucleus Brodmann (1909) area 40 Claustrum of brain Midbrain tectum Mammillary body Pontine reticular formation Pontine nuclear group Medial dorsal nucleus of thalamus Retrosplenial region Nucleus accumbens Medial zone of hypothalamus Intralaminar nuclear group Accessory basal amygdaloid nucleus Superior temporal gyrus Septal nuclear complex Cuneus cortex

50-year-old stage 60-year-old stage 42-year-old stage 29-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Mural cell Astrocyte Oligodendrocyte Microglial cell Fibroblast Ependymal cell Endothelial cell Neuron

Hypothalamus

91-year-old stage 50-year-old stage 67-year-old stage 92-year-old stage 63-year-old stage 59-year-old stage 42-year-old stage 94-year-old stage 88-year-old stage 29-year-old stage 83-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Inhibitory interneuron Glutamatergic neuron Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Endothelial cell of vascular tree Microglial cell Pericyte T cell

Insular cortex Brodmann (1909) area 4 Primary visual cortex

57-year-old stage 60-year-old stage 60-79 year-old stage 80 year-old and over stage 64-year-old stage 59-year-old stage 56-year-old stage 58-year-old stage 61-year-old stage

Normal Progressive supranuclear palsy Alzheimer disease Pick disease

Female Male

10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

Myofibroblast cell Pro-b cell Germ cell Transit amplifying cell Capillary endothelial cell Inflammatory macrophage Enteric smooth muscle cell Type i enteroendocrine cell Type n enteroendocrine cell Activated cd8-positive, alpha-beta t cell Colonocyte Naive b cell Nkp44-negative group 3 innate lymphoid cell, human Igg plasma cell Progenitor cell of endocrine pancreas Type ec enteroendocrine cell Oligodendrocyte precursor cell Endothelial cell of lymphatic vessel Glial cell Colon epithelial cell Cd4-positive, alpha-beta t cell Iga plasma cell Macrophage Nkp44-positive group 3 innate lymphoid cell, human Mesothelial cell Neuroblast (sensu vertebrata) Mucosal invariant t cell T-helper 1 cell Stromal cell Interstitial cell of cajal Mast cell Mesodermal cell Epithelial cell Type b pancreatic cell Neutrophil Stem cell Monocyte Interneuron Megakaryocyte Enteroendocrine cell Common lymphoid progenitor Immature b cell Gip cell Type l enteroendocrine cell Type d enteroendocrine cell Progenitor cell Vein endothelial cell Mesenchymal lymphangioblast Primary sensory neuron (sensu teleostei) Motor neuron Cd8-positive, alpha-beta memory t cell Conventional dendritic cell Group 3 innate lymphoid cell Intestinal tuft cell T-helper 17 cell Pericyte Follicular dendritic cell B cell Cd8-positive, alpha-beta t cell Group 2 innate lymphoid cell Activated cd4-positive, alpha-beta t cell Plasma cell Erythrocyte Regulatory t cell Mature nk t cell T cell Memory b cell Plasmacytoid dendritic cell Precursor b cell Igm plasma cell Inhibitory motor neuron T follicular helper cell Stromal cell of lamina propria of small intestine Cd34-positive, cd56-positive, cd117-positive common innate lymphoid precursor, human Natural killer cell Endothelial cell of artery Reticular cell Gamma-delta t cell Migratory enteric neural crest cell M cell of gut Germinal center b cell Intestine goblet cell

Ileum Rectum Mesenteric lymph node Caecum Small intestine Jejunum Transverse colon Sigmoid colon Duodenum Colon Descending colon Ascending colon Vermiform appendix Large intestine Lymph node

12th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 22 Eighth decade stage 11th week post-fertilization stage 14-year-old stage 6-year-old stage 17th week post-fertilization stage Fifth decade stage 15th week post-fertilization stage Carnegie stage 19 16th week post-fertilization stage 10-year-old stage 13-year-old stage Seventh decade stage Carnegie stage 23 12-year-old stage 4-year-old stage Carnegie stage 17 9-year-old stage Third decade stage Carnegie stage 20 Carnegie stage 16 Sixth decade stage 11-year-old stage

Normal Crohn disease

Female Male

10x 5' v2 10x 3' v2

Cell

Homo sapiens

Glutamatergic neuron Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Gabaergic neuron Microglial cell Blood vessel endothelial cell

Brodmann (1909) area 7 Brodmann (1909) area 17 Brodmann (1909) area 9

80-year-old stage 85-year-old stage 91-year-old stage 82-year-old stage 66-year-old stage 79-year-old stage 70-year-old stage 111-year-old stage 86-year-old stage 57-year-old stage 76-year-old stage 62-year-old stage 93-year-old stage 52-year-old stage 89-year-old stage 67-year-old stage 92-year-old stage 75-year-old stage 71-year-old stage 58-year-old stage 68-year-old stage 61-year-old stage 73-year-old stage 88-year-old stage 97-year-old stage 87-year-old stage 81-year-old stage 83-year-old stage

Normal Alzheimer disease

Female Male

10x 3' v3 Drop-seq 10x 3' v2

Nucleus

Homo sapiens

Naive b cell Classical monocyte Innate lymphoid cell Class switched memory b cell Platelet Non-classical monocyte Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell Cd4-positive helper t cell Cd16-negative, cd56-bright natural killer cell, human Plasmablast Cd8-positive, alpha-beta cytotoxic t cell Granulocyte Conventional dendritic cell Naive thymus-derived cd8-positive, alpha-beta t cell Effector memory cd8-positive, alpha-beta t cell Hematopoietic precursor cell Central memory cd8-positive, alpha-beta t cell B cell Cd4-positive, alpha-beta cytotoxic t cell Dendritic cell Plasma cell Erythrocyte Regulatory t cell Mature nk t cell Plasmacytoid dendritic cell Effector memory cd8-positive, alpha-beta t cell, terminally differentiated Natural killer cell Gamma-delta t cell

Blood

80-year-old stage 66-year-old stage 70-year-old stage 76-year-old stage 52-year-old stage Juvenile stage (5-14 yo) 25-year-old stage 92-year-old stage Postnatal stage Adult stage 56-year-old stage Pediatric stage 73-year-old stage 39-year-old stage Newborn stage (0-28 days) Late adult stage Child stage (1-4 yo)

Normal Post-covid-19 disorder Covid-19

Female Male

10x 5' v1

Cell

Homo sapiens

Cd4-positive, alpha-beta t cell Double-positive, alpha-beta thymocyte Monocyte Double negative thymocyte Cd8-positive, alpha-beta t cell

T cell

Fourth decade stage Eighth decade stage Ninth decade stage Fifth decade stage Seventh decade stage Third decade stage Sixth decade stage

B-cell non-hodgkin lymphoma

Female Male

10x 5' v1

Cell

Homo sapiens

Capillary endothelial cell Endothelial cell of lymphatic vessel Endothelial tip cell Perivascular cell Fibroblast of mammary gland Vein endothelial cell Endothelial cell of artery

Breast

19-year-old stage 21-year-old stage 57-year-old stage 62-year-old stage 46-year-old stage 52-year-old stage 48-year-old stage 45-year-old stage 25-year-old stage 33-year-old stage 65-year-old stage 40-year-old stage 27-year-old stage 23-year-old stage 37-year-old stage 28-year-old stage 36-year-old stage 63-year-old stage 59-year-old stage 20-year-old stage 31-year-old stage 56-year-old stage 58-year-old stage 34-year-old stage 35-year-old stage 53-year-old stage 30-year-old stage 24-year-old stage 39-year-old stage 29-year-old stage 38-year-old stage 41-year-old stage 55-year-old stage

Normal

Female

10x 3' v3

Cell