Homo sapiens

T cell Neutrophil Natural killer cell Endothelial cell of lymphatic vessel Erythrocyte Small pre-b-ii cell Gamma-delta t cell Thymic fibroblast type 1 Medullary thymic epithelial cell type 2 Pro-b cell Medullary thymic epithelial cell type 3 Corticomedullary thymic epithelial cell Mast cell Cd8-positive, alpha-beta t cell Myo-medullary thymic epithelial cell Medullary thymic epithelial cell type 1 Cortical thymic epithelial cell Late pro-b cell Double-positive, alpha-beta thymocyte Endothelial cell of artery Capillary endothelial cell Schwann cell Smooth muscle cell Thymic fibroblast type 2 Plasmacytoid dendritic cell Precursor b cell Immature alpha-beta t cell Cd8-positive, alpha-beta memory t cell Macrophage Memory b cell Regulatory t cell Myelocyte Neuro-medullary thymic epithelial cell Large pre-b-ii cell Promonocyte Common myeloid progenitor Plasma cell Cd4-positive, alpha-beta t cell Vein endothelial cell Mesothelial cell Ciliated epithelial cell B cell Pericyte Granulocyte monocyte progenitor cell Cd8-positive, alpha-beta regulatory t cell Monocyte Early t lineage precursor Naive b cell Double negative thymocyte Conventional dendritic cell Fibroblast

Thymus

13th week post-fertilization stage 2-year-old stage 3-month-old stage 14th week post-fertilization stage 15th week post-fertilization stage 20th week post-fertilization stage 17th week post-fertilization stage 12th week post-fertilization stage 6-month-old stage 18th week post-fertilization stage 10-month-old stage 2-month-old stage Newborn stage (0-28 days) 5-month-old stage 24th week post-fertilization stage 14-month-old stage

Normal

Female Male

10x 5' v2 10x 5' v1 10x 3' v3 10x 3' v2

Cell

Callithrix jacchus

Glutamatergic neuron

Brodmann (1909) area 23 Brodmann (1909) area 25 Dorsolateral prefrontal cortex Parietal cortex Prefrontal cortex Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Secondary visual cortex Temporal cortex Temporal lobe

Late adult stage Prime adult stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Ciliated cell Natural killer cell Granzyme k-associated cd8 t cell Lung secretory cell Pulmonary capillary endothelial cell Myeloid dendritic cell, human Mast cell Lung interstitial macrophage Pulmonary neuroendocrine cell Endothelial cell of arteriole Basal cell Endothelial cell of respiratory system lymphatic vessel Classical monocyte Smooth muscle cell Plasmacytoid dendritic cell Cd8-positive, alpha-beta cytotoxic t cell Mesothelial cell of pleura Macrophage Pulmonary alveolar type 1 cell Helper t cell Alveolar macrophage Plasma cell Vein endothelial cell of respiratory system B cell Pericyte Alveolar type 1 fibroblast cell Epithelial cell of lung Monocyte Myofibroblast cell Conventional dendritic cell Adventitial fibroblast Hematopoietic cell Pulmonary alveolar type 2 cell

Lung

66-year-old stage 69-year-old stage 34-year-old stage 65-year-old stage 43-year-old stage 71-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 54-year-old stage 68-year-old stage 30-year-old stage 44-year-old stage 17-year-old stage 29-year-old stage 38-year-old stage 56-year-old stage 55-year-old stage 15-year-old stage 50-year-old stage 57-year-old stage 72-year-old stage 74-year-old stage 49-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 25-year-old stage 67-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 31-year-old stage 36-year-old stage 19-year-old stage 63-year-old stage 47-year-old stage 73-year-old stage 27-year-old stage 40-year-old stage

Non-specific interstitial pneumonia Interstitial lung disease Anthracosis Pulmonary sarcoidosis Hypersensitivity pneumonitis Lymphoid interstitial pneumonia Normal

Female Male

10x 5' v2 10x 5' v1

Cell

Homo sapiens

Dendritic cell, human Cd14-positive, cd16-positive monocyte Natural killer cell Cd8-positive, alpha-beta t cell Platelet Plasmacytoid dendritic cell Lymphocyte Naive thymus-derived cd8-positive, alpha-beta t cell Memory b cell Plasma cell Cd4-positive, alpha-beta t cell Cd14-positive monocyte Naive b cell

Blood

37-year-old stage 21-year-old stage 34-year-old stage 42-year-old stage 26-year-old stage 43-year-old stage 53-year-old stage 52-year-old stage 54-year-old stage 48-year-old stage 30-year-old stage 39-year-old stage 44-year-old stage 29-year-old stage 38-year-old stage 55-year-old stage 50-year-old stage 28-year-old stage 51-year-old stage 57-year-old stage 49-year-old stage 24-year-old stage 23-year-old stage 35-year-old stage 58-year-old stage 25-year-old stage 32-year-old stage 33-year-old stage 45-year-old stage 41-year-old stage 46-year-old stage 60-year-old stage 18-year-old stage 31-year-old stage 36-year-old stage 22-year-old stage 19-year-old stage 20-year-old stage 47-year-old stage 27-year-old stage 40-year-old stage

Normal

Female Male

10x 5' v2

Cell

Homo sapiens

Blood vessel endothelial cell Glutamatergic neuron Oligodendrocyte precursor cell Cerebral cortex gabaergic interneuron Cajal-retzius cell Microglial cell Forebrain radial glial cell Progenitor cell Cerebral cortex endothelial cell

Parietal cortex Prefrontal cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Temporal cortex

19th week post-fertilization stage 25th week post-fertilization stage 14th week post-fertilization stage 20th week post-fertilization stage 17th week post-fertilization stage 16th week post-fertilization stage 18th week post-fertilization stage 22nd week post-fertilization stage

Normal

10x 3' v2

Cell

Homo sapiens

Be cell Memory b cell Plasma cell Transitional stage b cell Naive b cell

Blood

66-year-old stage 69-year-old stage 75-year-old stage 65-year-old stage 42-year-old stage 89-year-old stage 43-year-old stage 87-year-old stage 71-year-old stage 85-year-old stage 53-year-old stage 61-year-old stage 88-year-old stage 52-year-old stage 54-year-old stage 68-year-old stage 48-year-old stage 44-year-old stage 56-year-old stage 55-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 51-year-old stage 57-year-old stage 72-year-old stage 81-year-old stage 74-year-old stage 80 year-old and over stage 49-year-old stage 58-year-old stage 59-year-old stage 67-year-old stage 77-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 86-year-old stage 41-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 78-year-old stage 63-year-old stage 47-year-old stage 76-year-old stage 79-year-old stage 73-year-old stage 83-year-old stage 40-year-old stage

Cytomegalovirus infection Normal

Female Male

10x gene expression flex

Cell

Homo sapiens

Intratelencephalic-projecting glutamatergic cortical neuron

Brodmann (1909) area 13 Brodmann (1909) area 14 Brodmann (1909) area 19 Brodmann (1909) area 23 Brodmann (1909) area 24 Brodmann (1909) area 25 Brodmann (1909) area 32 Brodmann (1909) area 38 Brodmann (1909) area 40 Brodmann (1909) area 43 Brodmann (1909) area 46 Accessory basal amygdaloid nucleus Agranular insular cortex Anterior cortical amygdaloid nucleus Anterior nuclear group Anterior olfactory nucleus Basolateral amygdaloid nuclear complex Bed nucleus of stria terminalis Body of caudate nucleus Central amygdaloid nucleus Claustrum of brain Corticomedial nuclear complex Cuneus cortex Dentate gyrus of hippocampal formation Dorsal tegmental nucleus Epithalamus Extrastriate cortex Globus pallidus Granular insular cortex Gray matter of midbrain Hippocampal field Hypothalamus Inferior frontal gyrus Inferior olivary complex Inferior temporal gyrus Intralaminar nuclear group Lateral amygdaloid nucleus Lateral entorhinal cortex Lateral geniculate body Lateral nuclear group of thalamus Lateral posterior nucleus of thalamus Mammillary body Medial dorsal nucleus of thalamus Medial entorhinal cortex Medial geniculate body Medial zone of hypothalamus Midbrain nucleus Midbrain tectum Middle temporal gyrus Nucleus accumbens Nucleus of dorsal thalamus Nucleus of medulla oblongata Parabrachial nucleus Perirhinal cortex Piriform cortex Pontine nuclear group Pontine reticular formation Pontine tegmentum Posterior parahippocampal gyrus Preoptic area Pretectal region Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Pulvinar nucleus Putamen Red nucleus Retrosplenial region Septal nuclear complex Spinal cord Subicular complex Substantia innominata Substantia nigra Subthalamic nucleus Superior parietal cortex Superior temporal gyrus Supraoptic nucleus Temporal fusiform gyrus Ventral anterior nucleus of thalamus

42-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Endothelial cell Oligodendrocyte Ependymal cell Microglial cell Mural cell Neuron Astrocyte Fibroblast

Hypothalamus

91-year-old stage 42-year-old stage 88-year-old stage 29-year-old stage 92-year-old stage 50-year-old stage 59-year-old stage 67-year-old stage 94-year-old stage 63-year-old stage 83-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

T cell Glutamatergic neuron Oligodendrocyte precursor cell Oligodendrocyte Inhibitory interneuron Endothelial cell of vascular tree Microglial cell Pericyte Astrocyte

Brodmann (1909) area 4 Insular cortex Primary visual cortex

61-year-old stage 56-year-old stage 57-year-old stage 80 year-old and over stage 58-year-old stage 59-year-old stage 64-year-old stage 60-year-old stage 60-79 year-old stage

Pick disease Progressive supranuclear palsy Normal Alzheimer disease

Female Male

10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

T cell Neutrophil Germinal center b cell Nkp44-positive group 3 innate lymphoid cell, human Igm plasma cell Gip cell Stromal cell Intestine goblet cell Natural killer cell Endothelial cell of lymphatic vessel Erythrocyte Oligodendrocyte precursor cell Follicular dendritic cell Type n enteroendocrine cell Progenitor cell of endocrine pancreas Gamma-delta t cell Activated cd4-positive, alpha-beta t cell Reticular cell Mature nk t cell Pro-b cell Interstitial cell of cajal Mast cell Cd8-positive, alpha-beta t cell Stromal cell of lamina propria of small intestine Iga plasma cell Inflammatory macrophage Group 2 innate lymphoid cell Stem cell Endothelial cell of artery Capillary endothelial cell Epithelial cell Inhibitory motor neuron Intestinal tuft cell Plasmacytoid dendritic cell Igg plasma cell Precursor b cell Enteroendocrine cell Mesodermal cell Cd8-positive, alpha-beta memory t cell Group 3 innate lymphoid cell T-helper 17 cell Macrophage Memory b cell Nkp44-negative group 3 innate lymphoid cell, human Regulatory t cell Enteric smooth muscle cell Neuroblast (sensu vertebrata) Migratory enteric neural crest cell Activated cd8-positive, alpha-beta t cell Type ec enteroendocrine cell Glial cell Plasma cell Cd4-positive, alpha-beta t cell Vein endothelial cell Type b pancreatic cell Mesenchymal lymphangioblast Motor neuron Megakaryocyte Interneuron Transit amplifying cell T follicular helper cell Mesothelial cell Germ cell B cell Pericyte Progenitor cell Common lymphoid progenitor Mucosal invariant t cell Colon epithelial cell Immature b cell Type d enteroendocrine cell T-helper 1 cell Type i enteroendocrine cell Monocyte Naive b cell Myofibroblast cell Conventional dendritic cell Colonocyte Type l enteroendocrine cell M cell of gut Primary sensory neuron (sensu teleostei) Cd34-positive, cd56-positive, cd117-positive common innate lymphoid precursor, human

Ascending colon Caecum Colon Descending colon Duodenum Ileum Jejunum Large intestine Lymph node Mesenteric lymph node Rectum Sigmoid colon Small intestine Transverse colon Vermiform appendix

Carnegie stage 19 13-year-old stage Sixth decade stage Fifth decade stage 15th week post-fertilization stage 17th week post-fertilization stage 12-year-old stage 12th week post-fertilization stage Third decade stage 16th week post-fertilization stage Carnegie stage 20 9-year-old stage Carnegie stage 23 10th week post-fertilization stage 14-year-old stage Seventh decade stage Carnegie stage 17 Carnegie stage 22 Carnegie stage 16 Eighth decade stage 11-year-old stage 6-year-old stage 10-year-old stage 4-year-old stage 11th week post-fertilization stage

Normal Crohn disease

Female Male

10x 5' v2 10x 3' v2

Cell

Homo sapiens

T cell Lymphocyte of b lineage Perivascular cell Endothelial cell Abnormal cell Myeloid leukocyte Fibroblast

Breast

Middle aged stage Late adult stage Young adult stage

Triple-negative breast carcinoma

Female

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Blood vessel endothelial cell Glutamatergic neuron Oligodendrocyte precursor cell Oligodendrocyte Microglial cell Astrocyte Gabaergic neuron

Brodmann (1909) area 17 Brodmann (1909) area 7 Brodmann (1909) area 9

66-year-old stage 75-year-old stage 91-year-old stage 89-year-old stage 93-year-old stage 87-year-old stage 71-year-old stage 85-year-old stage 61-year-old stage 88-year-old stage 52-year-old stage 68-year-old stage 92-year-old stage 111-year-old stage 82-year-old stage 80-year-old stage 57-year-old stage 81-year-old stage 97-year-old stage 58-year-old stage 67-year-old stage 62-year-old stage 86-year-old stage 70-year-old stage 76-year-old stage 79-year-old stage 73-year-old stage 83-year-old stage

Normal Alzheimer disease

Female Male

10x 3' v3 Drop-seq 10x 3' v2

Nucleus