Drosophila melanogaster

Ovarian sheath muscle cell

Ovary

Day 5 of adulthood

Normal

Female

10x 3' v3

Mus musculus

Oligodendrocyte precursor cell Committed oligodendrocyte precursor

Embryo

Theiler stage 23 Theiler stage 24 Theiler stage 21 Theiler stage 25 Theiler stage 26 Theiler stage 20 Theiler stage 19 Theiler stage 27 Theiler stage 22

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Ependymal cell Pericyte Endothelial cell Neuron Central nervous system macrophage Choroid plexus epithelial cell

Anterior nuclear group

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Pericyte Endothelial cell Neuron Central nervous system macrophage

Anterior olfactory nucleus

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Autosomal dominant polycystic kidney disease

Male

Slide-seqv2

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Ependymal cell Pericyte Endothelial cell Neuron Central nervous system macrophage

Accessory basal amygdaloid nucleus

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Pericyte Endothelial cell Neuron Central nervous system macrophage

Brodmann (1909) area 46

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Mesodermal cell Epithelial cell Hematopoietic cell Endothelial cell Mesenchymal cell

Bone marrow

Normal

Male

10x 3' v3

Cell

Homo sapiens

Adipocyte of omentum tissue Mesenchymal stem cell of adipose tissue

Visceral fat

48-year-old stage 33-year-old stage Adult stage 28-year-old stage 34-year-old stage 53-year-old stage 24-year-old stage 29-year-old stage 41-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Umbrella cell of urothelium Basal cell of urothelium Cytotoxic t cell Leukocyte Mast cell Fibroblast Urothelial cell Endothelial cell Intermediate cell of urothelium B cell Mature nk t cell T cell Smooth muscle cell

Ureter

85-year-old stage 82-year-old stage 79-year-old stage 74-year-old stage 65-year-old stage 75-year-old stage 68-year-old stage 69-year-old stage 81-year-old stage

Normal

Female Male

10x 3' v3

Cell

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Autosomal dominant polycystic kidney disease

Male

Slide-seqv2

Homo sapiens

Progenitor cell of mammary luminal epithelium Cd4-positive, alpha-beta t cell Macrophage Mast cell Basal cell Fibroblast of breast Luminal epithelial cell of mammary gland Vascular associated smooth muscle cell Endothelial cell B cell Cd8-positive, alpha-beta t cell Plasma cell Regulatory t cell Mature nk t cell T cell Basophil Natural killer cell

Mammary gland

56-year-old stage 38-year-old stage

Normal

Female

Smart-seq2 10x 3' v3

Cell