Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Bergmann glial cell Vascular associated smooth muscle cell Fibroblast Ependymal cell Pericyte Endothelial cell Neuron Central nervous system macrophage Choroid plexus epithelial cell

Midbrain tectum

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Pericyte Endothelial cell Neuron Central nervous system macrophage

Brodmann (1909) area 24

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney granular cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Macula densa epithelial cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Normal

Male

Slide-seqv2

Homo sapiens

Cd4-positive helper t cell

Normal

10x scatac-seq

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney granular cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Macula densa epithelial cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Neocortex

Adult stage

Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Pericyte Endothelial cell Neuron Central nervous system macrophage

Temporal fusiform gyrus

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Luminal hormone-sensing cell of mammary gland Endothelial cell of lymphatic vessel Luminal adaptive secretory precursor cell of mammary gland Endocrine cell B cell Basal-myoepithelial cell of mammary gland

Upper outer quadrant of breast

21-year-old stage 60-year-old stage 44-year-old stage Adult stage 42-year-old stage 35-year-old stage 43-year-old stage

Normal

Female

10x 3' v3 10x 3' v2

Cell

Drosophila melanogaster

Muscle cell Adult alary muscle cell Female germline cell Tracheolar cell Somatic precursor cell Epithelial cell Neuron Sensory neuron Cardial cell Fat cell Adult neuron Hemocyte Male germline cell Oenocyte Neuron Adult oenocyte Glial cell

Fat body

Day 3 of adulthood

Normal

Female Male

10x 3' v3

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney granular cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Macula densa epithelial cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Homo sapiens

Pro-b cell Pre-natural killer cell Naive b cell Erythroid progenitor cell Classical monocyte Cd4-positive, alpha-beta memory t cell Megakaryocyte progenitor cell Class switched memory b cell Non-classical monocyte Late promyelocyte Naive thymus-derived cd4-positive, alpha-beta t cell Unswitched memory b cell Megakaryocyte-erythroid progenitor cell Cd16-negative, cd56-bright natural killer cell, human Erythroid lineage cell Fraction a pre-pro b cell Immature b cell Lymphoid lineage restricted progenitor cell Progenitor cell Cd8-positive, alpha-beta memory t cell Conventional dendritic cell Naive thymus-derived cd8-positive, alpha-beta t cell Effector memory cd8-positive, alpha-beta t cell Central memory cd8-positive, alpha-beta t cell Mesenchymal cell Cd4-positive, alpha-beta cytotoxic t cell Plasma cell Memory b cell Plasmacytoid dendritic cell Common dendritic progenitor Myelocyte Precursor b cell Early promyelocyte Natural killer cell Hematopoietic multipotent progenitor cell Basophil mast progenitor cell Gamma-delta t cell Cd16-positive, cd56-dim natural killer cell, human

Bone marrow

66-year-old stage 70-year-old stage 32-year-old stage 62-year-old stage 46-year-old stage 44-year-old stage 45-year-old stage 71-year-old stage 78-year-old stage 54-year-old stage 56-year-old stage 61-year-old stage 51-year-old stage 55-year-old stage

Acute promyelocytic leukemia Acute myeloid leukemia

Female Male

Bd rhapsody targeted mrna

Cell

Homo sapiens

Myoepithelial cell Mural cell Endothelial cell of lymphatic vessel Ionocyte Macrophage Cd4-positive helper t cell Adult skeletal muscle myoblast Neutrophil Acinar cell of salivary gland Fibroblast Blood vessel endothelial cell Salivary gland glandular cell B cell Cd8-positive, alpha-beta t cell Dendritic cell Plasma cell Keratinocyte Natural killer cell

Minor salivary gland

48-year-old stage 40-year-old stage 28-year-old stage 56-year-old stage 34-year-old stage 53-year-old stage 24-year-old stage 26-year-old stage 39-year-old stage

Normal

Female Male

10x 3' v3

Cell