Homo sapiens

Astrocyte Ependymal cell

Substantia nigra pars compacta

91-year-old stage 82-year-old stage 79-year-old stage 70-year-old stage 76-year-old stage 89-year-old stage 74-year-old stage 92-year-old stage 75-year-old stage 78-year-old stage 49-year-old stage 90-year-old stage 83-year-old stage

Normal Lewy body dementia Parkinson disease

Female Male

10x 3' v3

Nucleus

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Pericyte Endothelial cell Neuron Central nervous system macrophage

Primary visual cortex

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Rattus norvegicus

Inflammatory macrophage Type i nk t cell Classical monocyte Endothelial cell of lymphatic vessel Type ii nk t cell Pulmonary alveolar type 2 cell Club cell Non-classical monocyte Mesothelial cell Alveolar macrophage Neoplastic cell Mast cell Naive t cell Neutrophil Cd8-positive, alpha-beta cytotoxic t cell Conventional dendritic cell B cell Lung macrophage Regulatory t cell T cell Plasmacytoid dendritic cell Endothelial cell of umbilical vein Fibroblast of lung Smooth muscle cell Ciliated cell

Normal Pulmonary hypertension, primary, 1 Pulmonary hypertension owing to lung disease and/or hypoxia

Drop-seq

Homo sapiens

Macrophage Blood vessel smooth muscle cell Fibroblast Malignant cell Blood vessel endothelial cell T cell

Axilla

27-year-old stage

Breast cancer

Female

Slide-seqv2

Homo sapiens

Inhibitory interneuron Pyramidal neuron Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Cell Microglial cell Endothelial cell

Normal Isolated focal cortical dysplasia Tuberous sclerosis Hemimegalencephaly

10x 3' v3

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney granular cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Macula densa epithelial cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Normal

Male

Slide-seqv2

Homo sapiens

Endothelial cell of lymphatic vessel Cd4-positive, alpha-beta t cell Macrophage Interstitial cell of cajal Mast cell Epithelial cell Neutrophil Monocyte Enteroendocrine cell Fibroblast Tissue-resident macrophage B cell Cd8-positive, alpha-beta t cell Plasma cell Regulatory t cell Mature nk t cell T cell Smooth muscle cell Natural killer cell Mononuclear phagocyte

Stomach smooth muscle Mucosa of stomach Muscularis mucosae of stomach Stomach

60-year-old stage 56-year-old stage

Normal

Female Male

Smart-seq2 10x 3' v3

Cell

Homo sapiens

Macrophage Microglial cell

Substantia nigra pars compacta

91-year-old stage 82-year-old stage 79-year-old stage 70-year-old stage 76-year-old stage 89-year-old stage 74-year-old stage 92-year-old stage 75-year-old stage 78-year-old stage 49-year-old stage 90-year-old stage 83-year-old stage

Normal Lewy body dementia Parkinson disease

Female Male

10x 3' v3

Nucleus

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney granular cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Normal

Male

Slide-seqv2

Mus musculus

Tracheal epithelial cell

Tracheal epithelial cell

Mature stage

Normal

10x 3' v3

Cell

Callithrix jacchus

Neuron

Posterior hypothalamic region Anterior hypothalamic region

Prime adult stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney granular cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Macula densa epithelial cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2