Callithrix jacchus

Oligodendrocyte precursor cell Oligodendrocyte Vascular leptomeningeal cell Pvalb chandelier gabaergic interneuron Lamp5 gabaergic interneuron Microglial cell Vip gabaergic interneuron L2/3-6 intratelencephalic projecting glutamatergic neuron L5 extratelencephalic projecting glutamatergic cortical neuron L6b glutamatergic cortical neuron Pvalb gabaergic interneuron Near-projecting glutamatergic cortical neuron Cerebral cortex endothelial cell Caudal ganglionic eminence derived interneuron Sncg gabaergic interneuron Astrocyte of the cerebral cortex Sst gabaergic interneuron Corticothalamic-projecting glutamatergic cortical neuron

Middle temporal gyrus

Prime adult stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Sst gabaergic interneuron

Dorsolateral prefrontal cortex

69-year-old stage 75-year-old stage 42-year-old stage 89-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 77-year-old stage 86-year-old stage 70-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Callithrix jacchus

Oligodendrocyte

Dorsolateral prefrontal cortex Parietal cortex Primary visual cortex Temporal cortex Prefrontal cortex Temporal lobe Primary somatosensory cortex Primary auditory cortex Brodmann (1909) area 23 Primary motor cortex Secondary visual cortex

Prime adult stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Endothelial cell Lymphocyte Glial cell Pericyte Myofibroblast cell Fibroblast

Ileal epithelium Small intestine Ileum Ileum lamina propria Lamina propria of small intestine

Sixth decade stage Fifth decade stage Third decade stage Seventh decade stage Fourth decade stage Eighth decade stage

Normal Crohn disease

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Central nervous system macrophage Glutamatergic neuron Oligodendrocyte precursor cell Perivascular cell Endothelial cell Oligodendrocyte Microglial cell Pericyte Astrocyte Gabaergic neuron

Primary motor cortex

75-year-old stage 68-year-old stage 80-year-old stage 67-year-old stage 73-year-old stage 83-year-old stage

Amyotrophic lateral sclerosis Normal

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

T cell Neutrophil Hepatocyte Natural killer cell Endothelial cell Mast cell Plasmacytoid dendritic cell Cholangiocyte Plasma cell Malignant cell B cell Conventional dendritic cell Fibroblast Mononuclear phagocyte

Liver

53-year-old stage 39-year-old stage 56-year-old stage 70-year-old stage 46-year-old stage

Metastatic malignant neoplasm Colorectal carcinoma Normal

Female Male

Bd rhapsody whole transcriptome analysis

Cell

Homo sapiens

Trophoblast giant cell Extravillous trophoblast Placental villous trophoblast Syncytiotrophoblast cell

Decidua Placenta Decidua basalis

Carnegie stage 14 13th week post-fertilization stage 9th week post-fertilization stage Carnegie stage 23 10th week post-fertilization stage Carnegie stage 22 Carnegie stage 16 Carnegie stage 18 11th week post-fertilization stage

Normal

Female

10x multiome 10x 3' v3 10x 3' v2

Cell Nucleus

Homo sapiens

Hippocampal ca1-3 neuron

Subthalamic nucleus Medial geniculate body Brodmann (1909) area 25 Lateral amygdaloid nucleus Corticomedial nuclear complex Rostral ca3 Subicular complex Piriform cortex Hippocampal field Middle temporal gyrus Septal nuclear complex Supraoptic nucleus Medial entorhinal cortex Substantia nigra Brodmann (1909) area 14 Anterior olfactory nucleus Accessory basal amygdaloid nucleus Pulvinar nucleus Hypothalamus Primary motor cortex Brodmann (1909) area 46 Posterior parahippocampal gyrus Basolateral amygdaloid nuclear complex Retrosplenial region Dentate gyrus of hippocampal formation Mammillary body Uncal ca1 Bed nucleus of stria terminalis Lateral geniculate body

42-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Pancreatic a cell

Islet of langerhans

66-year-old stage 37-year-old stage 21-year-old stage 34-year-old stage 42-year-old stage 26-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 54-year-old stage 48-year-old stage 30-year-old stage 38-year-old stage 55-year-old stage 50-year-old stage 51-year-old stage 57-year-old stage 49-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 25-year-old stage 32-year-old stage 45-year-old stage 62-year-old stage 60-year-old stage 63-year-old stage 40-year-old stage

Prediabetes syndrome Normal Type 2 diabetes mellitus

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Muscle cell Type ii muscle cell Type i muscle cell

Intercostal muscle

Sixth decade stage Third decade stage Seventh decade stage Fourth decade stage Eighth decade stage Young adult stage

Normal

Female Male

10x 3' v3 10x 3' v2

Nucleus

Callithrix jacchus

Neuron

Thalamic complex Medial dorsal nucleus of thalamus Ventral lateral nucleus of thalamus Lateral nuclear group of thalamus Ventral thalamus Dorsal thalamus Lateral geniculate body

Late adult stage Prime adult stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Pyramidal neuron Central nervous system macrophage Glutamatergic neuron L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex Endothelial cell Oligodendrocyte Hippocampal neuron Meis2 expressing cortical gabaergic cell Vascular leptomeningeal cell (mmus) Lamp5 gabaergic interneuron Cajal-retzius cell L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex Vip gabaergic interneuron L2/3-6 intratelencephalic projecting glutamatergic neuron L5 extratelencephalic projecting glutamatergic cortical neuron L6b glutamatergic cortical neuron L6 corticothalamic-projecting glutamatergic cortical neuron Pvalb gabaergic interneuron Pericyte L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex Sncg gabaergic interneuron Sst chodl gabaergic interneuron Astrocyte L5/6 near-projecting glutamatergic neuron of the primary motor cortex Sst gabaergic interneuron Cortical interneuron Corticothalamic-projecting glutamatergic cortical neuron

Auditory cortex Secondary somatosensory cortex Primary visual cortex Claustrum of brain Temporal cortex Subicular complex Prefrontal cortex Frontal cortex Lateral entorhinal cortex Gustatory cortex Medial entorhinal cortex Posterior parietal association areas Agranular insular cortex Primary somatosensory cortex Primary motor cortex Hippocampal formation Visual cortex Medial orbital frontal cortex Anterior cingulate cortex Retrosplenial region

9-week-old stage 15-week-old stage 13-week-old stage 12-week-old stage 14-week-old stage 11-week-old stage 7-week-old stage 10-week-old stage 8-week-old stage

Normal

Female Male

Smart-seq v4

Cell