Homo sapiens

Vip gabaergic interneuron

Dorsolateral prefrontal cortex

80-year-old stage 85-year-old stage 82-year-old stage 70-year-old stage 77-year-old stage 50-year-old stage 86-year-old stage 80 year-old and over stage 89-year-old stage 75-year-old stage 78-year-old stage 68-year-old stage 42-year-old stage 72-year-old stage 88-year-old stage 84-year-old stage 69-year-old stage 29-year-old stage 87-year-old stage 81-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x 3' v3 10x multiome

Nucleus

Homo sapiens

Naive b cell Endothelial cell of lymphatic vessel Cd4-positive, alpha-beta t cell Macrophage Fibroblast of breast Monocyte Luminal epithelial cell of mammary gland Plasmablast Pericyte Endothelial cell Cd8-positive, alpha-beta t cell Mature nk t cell T cell Memory b cell Basal-myoepithelial cell of mammary gland Natural killer cell Mammary gland epithelial cell Myeloid cell

Breast

85-year-old stage 82-year-old stage 50-year-old stage 57-year-old stage 52-year-old stage 60-year-old stage 67-year-old stage 63-year-old stage 54-year-old stage 47-year-old stage 58-year-old stage 61-year-old stage 49-year-old stage 42-year-old stage 35-year-old stage 73-year-old stage 88-year-old stage 43-year-old stage 41-year-old stage 55-year-old stage

Invasive ductal breast carcinoma Invasive lobular breast carcinoma Breast carcinoma

Female

10x 5' v1 10x 3' v3 10x 3' v2

Cell

Homo sapiens

Retinal rod cell Astrocyte Retinal cone cell Mueller cell Retinal bipolar neuron Amacrine cell Retinal pigment epithelial cell Retinal ganglion cell Retina horizontal cell Myeloid cell

Retina

79-year-old stage 70-year-old stage 77-year-old stage 65-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Cardiac neuron Cardiac endothelial cell Cardiac muscle cell Endothelial cell of lymphatic vessel Lymphocyte Macrophage Mesothelial cell Mast cell Adipocyte Vascular associated smooth muscle cell Cardiac ventricle fibroblast Pericyte

Normal Cardiomyopathy

10x 3' v3

Homo sapiens

Endothelial cell of arteriole Endothelial cell of venule Vein endothelial cell Fenestrated endothelial cell Endothelial cell of artery

Chorioretinal region

82-year-old stage 16-year-old stage 77-year-old stage 21-year-old stage 32-year-old stage 50-year-old stage 86-year-old stage 62-year-old stage 46-year-old stage 60-year-old stage 64-year-old stage 25-year-old stage 65-year-old stage 27-year-old stage 71-year-old stage 63-year-old stage 47-year-old stage 58-year-old stage 68-year-old stage 34-year-old stage 53-year-old stage 10-year-old stage 17-year-old stage 72-year-old stage 30-year-old stage Newborn stage (0-28 days) 69-year-old stage 43-year-old stage 90 year-old and over stage 81-year-old stage 11-year-old stage

Normal

Female Male

10x 5' v2 10x 3' v3

Nucleus

Homo sapiens

Type b pancreatic cell

Islet of langerhans

66-year-old stage 21-year-old stage 32-year-old stage 50-year-old stage 57-year-old stage 62-year-old stage 52-year-old stage 60-year-old stage 48-year-old stage 45-year-old stage 25-year-old stage 40-year-old stage 37-year-old stage 63-year-old stage 59-year-old stage 54-year-old stage 58-year-old stage 61-year-old stage 34-year-old stage 51-year-old stage 49-year-old stage 42-year-old stage 35-year-old stage 53-year-old stage 30-year-old stage 26-year-old stage 38-year-old stage 55-year-old stage

Normal Prediabetes syndrome Type 2 diabetes mellitus

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Inhibitory interneuron Mural cell Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Medium spiny neuron Direct pathway medium spiny neuron Microglial cell Endothelial cell Indirect pathway medium spiny neuron

Putamen Caudate nucleus

60-year-old stage 40-year-old stage 23-year-old stage 37-year-old stage 54-year-old stage 42-year-old stage 35-year-old stage 39-year-old stage 41-year-old stage 55-year-old stage

Normal Opiate dependence

Female Male

10x 3' v3

Nucleus

Homo sapiens

Epithelial cell Paneth cell Stem cell Enteroendocrine cell Tuft cell Enterocyte Goblet cell

Lamina propria of mucosa of colon Caecum epithelium Colonic epithelium Cecum mucosa Mucosa of transverse colon Sigmoid colon Colon Descending colon Ascending colon Mucosa of sigmoid colon

Fourth decade stage Eighth decade stage Adult stage Fifth decade stage Seventh decade stage Third decade stage Sixth decade stage

Normal Crohn disease

Female Male

10x 3' v3 10x 3' v1 10x 3' v2

Cell

Homo sapiens

Naive b cell Cd4-positive, alpha-beta memory t cell Platelet Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell Cd16-negative, cd56-bright natural killer cell, human Neutrophil Cd14-positive monocyte Immature b cell Plasmablast Cd8-positive, alpha-beta memory t cell Conventional dendritic cell Naive thymus-derived cd8-positive, alpha-beta t cell Hematopoietic stem cell B cell Plasma cell Erythrocyte Regulatory t cell Mature nk t cell T cell Memory b cell Plasmacytoid dendritic cell Cd14-low, cd16-positive monocyte Natural killer cell Gamma-delta t cell Cd16-positive, cd56-dim natural killer cell, human

Blood

Covid-19

10x 5' v1

Cell

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney outer medulla collecting duct intercalated cell Endothelial cell of lymphatic vessel Kidney connecting tubule epithelial cell Parietal epithelial cell Kidney connecting tubule principal cell Non-classical monocyte Endothelial cell of arteriole Lymphocyte Kidney collecting duct alpha-intercalated cell Mast cell Renal interstitial pericyte Neutrophil Kidney interstitial alternatively activated macrophage Macula densa epithelial cell Vasa recta ascending limb cell Myeloid dendritic cell Renal beta-intercalated cell Renal principal cell Epithelial cell of proximal tubule Vascular associated smooth muscle cell Fibroblast Podocyte Glomerular capillary endothelial cell B cell Epithelial cell of early distal convoluted tubule Plasma cell Peritubular capillary endothelial cell Mesangial cell T cell Vasa recta descending limb cell Plasmacytoid dendritic cell Kidney proximal convoluted tubule epithelial cell Epithelial cell of proximal tubule segment 3 Kidney loop of henle thin ascending limb epithelial cell

Cortex of kidney

79-year-old stage 50-year-old stage 57-year-old stage 46-year-old stage 60-year-old stage 74-year-old stage 67-year-old stage 71-year-old stage 59-year-old stage 58-year-old stage 68-year-old stage 53-year-old stage 72-year-old stage 69-year-old stage 43-year-old stage

Normal

Female Male

10x 5' v1 10x 3' v3 10x multiome

Cell Nucleus

Drosophila melanogaster

Eo sensory organ accessory cell Muscle cell Escort cell Enteroendocrine cell Germline cell Follicle cell Indirect flight muscle cell Hemocyte Cell body glial cell Subperineurial glial cell

Day 5 of adulthood

Normal

Female Male Mixed sex

10x 3' v3

Homo sapiens

Best4+ enterocyte Transit amplifying cell Colonocyte Intestinal crypt stem cell Paneth cell Enteroendocrine cell Tuft cell of small intestine Enterocyte Intestine goblet cell

Lamina propria of mucosa of colon Rectum Epithelium of rectum Caecum Colonic epithelium Transverse colon Sigmoid colon Colon Descending colon Ascending colon Rectosigmoid junction Vermiform appendix Colonic mucosa

85-year-old stage 66-year-old stage 77-year-old stage 50-year-old stage 86-year-old stage 52-year-old stage 60-year-old stage Juvenile stage (5-14 yo) 44-year-old stage 74-year-old stage 33-year-old stage 67-year-old stage 2-year-old stage Eighth decade stage 23-year-old stage Adult stage 54-year-old stage Fifth decade stage 31-year-old stage Pediatric stage 51-year-old stage 35-year-old stage 30-year-old stage Seventh decade stage 84-year-old stage Third decade stage 5-year-old stage 29-year-old stage 81-year-old stage 55-year-old stage Sixth decade stage

Ulcerative colitis Inflammatory bowel disease Normal Colorectal cancer

Female Male

10x 5' v2 10x 5' v1 10x 3' v3 10x 5' transcription profiling 10x 3' v2

Cell