Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial cell Kidney connecting tubule epithelial cell Parietal epithelial cell Cytotoxic t cell Non-classical monocyte Kidney distal convoluted tubule epithelial cell Kidney collecting duct principal cell Mast cell Kidney loop of henle thin descending limb epithelial cell Kidney interstitial alternatively activated macrophage Monocyte Epithelial cell of proximal tubule Kidney collecting duct intercalated cell Conventional dendritic cell Podocyte Endothelial cell B cell Plasmacytoid dendritic cell, human Plasma cell Regulatory t cell Mature nk t cell T cell Natural killer cell Mononuclear phagocyte Kidney loop of henle thin ascending limb epithelial cell

Kidney

66-year-old stage Fourth decade stage 57-year-old stage 52-year-old stage 48-year-old stage 40-year-old stage Eighth decade stage Fifth decade stage 47-year-old stage 31-year-old stage 56-year-old stage 49-year-old stage 42-year-old stage 35-year-old stage 53-year-old stage 30-year-old stage Seventh decade stage 39-year-old stage Third decade stage 41-year-old stage Sixth decade stage

Normal Chronic kidney disease Acute kidney failure

Female Male

10x 3' v3

Cell

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Pericyte Endothelial cell Neuron Central nervous system macrophage

Middle temporal gyrus

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Mus musculus

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Macrophage Neutrophil Neural progenitor cell Microglial cell Fibroblast Ependymal cell Pericyte Endothelial cell Myeloid leukocyte B cell T cell Neuron Choroid plexus epithelial cell

Brain ischemia Normal

10x 3' v2

Homo sapiens

Schwann cell Capillary endothelial cell Endothelial cell of lymphatic vessel Helper t cell Macrophage Mucosal invariant t cell Merkel cell Mast cell Endothelial cell of venule Neutrophil Vascular associated smooth muscle cell Conventional dendritic cell Fibroblast T-helper 17 cell Pericyte B cell Plasma cell Regulatory t cell Mature nk t cell T cell Plasmacytoid dendritic cell Keratinocyte Natural killer cell Endothelial cell of artery Gamma-delta t cell Melanocyte Langerhans cell

Gingiva

Young adult stage 21-year-old stage 32-year-old stage 57-year-old stage 22-year-old stage 44-year-old stage 45-year-old stage 37-year-old stage Adult stage 28-year-old stage 31-year-old stage 61-year-old stage 34-year-old stage 51-year-old stage 42-year-old stage 35-year-old stage 30-year-old stage 24-year-old stage 26-year-old stage 39-year-old stage 29-year-old stage 38-year-old stage

Gingivitis Normal Periodontitis

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Naive b cell Naive thymus-derived cd4-positive, alpha-beta t cell Effector cd8-positive, alpha-beta t cell Cd16-negative, cd56-bright natural killer cell, human Plasmablast Cd14-positive, cd16-negative classical monocyte Cd8-positive, alpha-beta memory t cell Conventional dendritic cell Naive thymus-derived cd8-positive, alpha-beta t cell Effector cd4-positive, alpha-beta t cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell Memory b cell Plasmacytoid dendritic cell Cd14-low, cd16-positive monocyte Gamma-delta t cell Cd16-positive, cd56-dim natural killer cell, human

Blood

16-year-old stage 18-year-old stage 1-year-old stage 2-year-old stage 14-year-old stage 15-year-old stage 8-year-old stage 17-year-old stage 13-year-old stage 3-year-old stage 7-year-old stage 4-year-old stage 9-year-old stage 5-year-old stage 11-year-old stage

Normal Juvenile dermatomyositis

Female Male

10x 3' v3

Cell

Homo sapiens

Naive thymus-derived cd4-positive, alpha-beta t cell Memory t cell Cd8-positive, alpha-beta cytotoxic t cell Cd8-positive, alpha-beta memory t cell B cell Plasma cell Regulatory t cell T cell Plasmacytoid dendritic cell Natural killer cell Gamma-delta t cell

Liver

66-year-old stage 77-year-old stage 46-year-old stage 64-year-old stage 33-year-old stage 67-year-old stage 75-year-old stage Adult stage 28-year-old stage 58-year-old stage 68-year-old stage 49-year-old stage 53-year-old stage 72-year-old stage 73-year-old stage 55-year-old stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell Nucleus

Homo sapiens

Kupffer cell Cd4-positive, alpha-beta t cell Macrophage Endothelial cell of periportal hepatic sinusoid Monocyte Intrahepatic cholangiocyte Periportal region hepatocyte Vein endothelial cell Vascular associated smooth muscle cell Fibroblast Hepatic stellate cell Hepatic pit cell Plasma cell Endothelial cell of pericentral hepatic sinusoid Midzonal region hepatocyte Centrilobular region hepatocyte

Caudate lobe of liver

Young adult stage Prime adult stage Postnatal stage Late adult stage

Normal Primary sclerosing cholangitis Primary biliary cholangitis

Female Male

10x 3' v3

Nucleus

Homo sapiens

Oligodendrocyte precursor cell

Inferior frontal gyrus Middle temporal gyrus Putamen Brodmann (1909) area 24 Cerebellar vermis Posterior parahippocampal gyrus Anterior olfactory nucleus Brodmann (1909) area 38 Pretectal region Subicular complex Gray matter of midbrain Brodmann (1909) area 14 Brodmann (1909) area 19 Inferior temporal gyrus Hypothalamus Brodmann (1909) area 32 Cerebrocerebellum Dentate gyrus of hippocampal formation Lateral geniculate body Bed nucleus of stria terminalis Median tuberal portion Brodmann (1909) area 13 Primary somatosensory cortex Medial geniculate body Preoptic area Substantia innominata Perirhinal cortex Body of caudate nucleus Extrastriate cortex Lateral nuclear group of thalamus Dorsal tegmental nucleus Brodmann (1909) area 23 Centromedian nucleus of thalamus Brodmann (1909) area 35 Epithalamus Substantia nigra Central amygdaloid nucleus Rostral ca3 Granular insular cortex Agranular insular cortex Globus pallidus Basolateral amygdaloid nuclear complex Parabrachial nucleus Ventral anterior nucleus of thalamus Nucleus of dorsal thalamus Anterior cortical amygdaloid nucleus Anterior nuclear group Brodmann (1909) area 43 Primary auditory cortex Medial entorhinal cortex Red nucleus Corticomedial nuclear complex Lateral posterior nucleus of thalamus Brodmann (1909) area 46 Nucleus of medulla oblongata Supraoptic nucleus Uncal ca1 Cerebellar nuclear complex Temporal fusiform gyrus Lateral entorhinal cortex Brodmann (1909) area 25 Midbrain nucleus Primary motor cortex Pulvinar nucleus Pontine tegmentum Primary visual cortex Subthalamic nucleus Spinal cord Superior parietal cortex Hippocampal field Inferior olivary complex Piriform cortex Lateral amygdaloid nucleus Brodmann (1909) area 40 Claustrum of brain Midbrain tectum Mammillary body Pontine reticular formation Pontine nuclear group Medial dorsal nucleus of thalamus Retrosplenial region Nucleus accumbens Medial zone of hypothalamus Intralaminar nuclear group Accessory basal amygdaloid nucleus Superior temporal gyrus Septal nuclear complex Cuneus cortex

50-year-old stage 60-year-old stage 42-year-old stage 29-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Hypendymal cell Glutamatergic neuron Vascular leptomeningeal cell Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Gabaergic neuron Neural stem cell Macrophage Arachnoid barrier cell Immature astrocyte Neutrophil Monocyte Olfactory ensheathing cell Cholinergic neuron Dopaminergic neuron Microglial cell Vascular associated smooth muscle cell Tanycyte Ependymal cell Pericyte Endothelial cell B cell Dendritic cell T cell Neuroendocrine cell Natural killer cell Choroid plexus epithelial cell

Normal

10x 3' v2

Homo sapiens

Vip gabaergic interneuron

Middle temporal gyrus

80-year-old stage 85-year-old stage 82-year-old stage 70-year-old stage 77-year-old stage 50-year-old stage 86-year-old stage 60-year-old stage 80 year-old and over stage 89-year-old stage 65-year-old stage 75-year-old stage Adult stage 78-year-old stage 68-year-old stage 72-year-old stage 88-year-old stage 84-year-old stage 69-year-old stage 43-year-old stage 29-year-old stage 87-year-old stage 81-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x 3' v3 10x multiome

Nucleus

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Dorsolateral prefrontal cortex

80-year-old stage 85-year-old stage 82-year-old stage 70-year-old stage 77-year-old stage 50-year-old stage 86-year-old stage 80 year-old and over stage 89-year-old stage 75-year-old stage 78-year-old stage 68-year-old stage 42-year-old stage 72-year-old stage 88-year-old stage 84-year-old stage 69-year-old stage 29-year-old stage 87-year-old stage 81-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x 3' v3 10x multiome

Nucleus

Homo sapiens

Dopaminergic neuron Neuron

Substantia nigra pars compacta

91-year-old stage 82-year-old stage 79-year-old stage 92-year-old stage 49-year-old stage 90-year-old stage

Normal

Female Male

10x 3' v3

Nucleus