Homo sapiens

Endothelial cell Contractile cell Lymphocyte Adipocyte Macrophage Perineuronal satellite cell Sensory neuron of dorsal root ganglion Fibroblast Myelinating schwann cell

Fourth lumbar dorsal root ganglion Seventh thoracic dorsal root ganglion Fifth lumbar dorsal root ganglion

21-year-old stage 48-year-old stage 38-year-old stage 16-year-old stage 25-year-old stage 31-year-old stage Life cycle

Normal

Female Male

10x genomics v2 10x genomics v3

Homo sapiens

Oligodendrocyte

Middle temporal gyrus

69-year-old stage 75-year-old stage 65-year-old stage 89-year-old stage 43-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage Adult stage 77-year-old stage 86-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Drosophila melanogaster

Neuron Cholinergic neuron Indirect flight muscle cell Subperineurial glial cell Somatic muscle cell Fat cell Cardial cell Tracheolar cell Glial cell Somatic precursor cell Eo sensory organ accessory cell Polar follicle cell Male germline cell Leg taste bristle chemosensory neuron Gustatory receptor neuron Hemocyte Enteroendocrine cell Follicle cell Chordotonal neuron Epithelial cell Germline cell Muscle cell Astrocyte-like glial cell Leg muscle motor neuron Neurosecretory neuron Multidendritic neuron Escort cell Adult tracheocyte Adult glial cell Cns surface glial cell Perineurial glial cell Sensory neuron Oenocyte Adult oenocyte Adult astrocyte-like glial cell Spermatocyte Malpighian tubule type i cell Neuron Cell body glial cell Female germline cell

Day 5 of adulthood

Normal

Mixed sex Female Male

10x 3' v3

Mus musculus

Endothelial cell of hepatic sinusoid T cell Neutrophil Bladder urothelial cell Endocardial cell Club cell Granulocyte Tuft cell of large intestine Neural stem cell Hepatocyte Stromal cell Natural killer cell Endothelial cell of lymphatic vessel Oligodendrocyte precursor cell Multiciliated columnar cell of tracheobronchial tree Mature alpha-beta t cell Secretory cell Kidney collecting duct epithelial cell Endothelial cell Kupffer cell Oligodendrocyte Cardiac valve cell Mature nk t cell Kidney interstitial fibroblast Cd8-positive, alpha-beta t cell Pulmonary neuroendocrine cell Pancreatic acinar cell Pancreatic pp cell Late pro-b cell Basal cell Luminal epithelial cell of mammary gland Bladder cell Leukocyte Classical monocyte Smooth muscle cell Intermediate monocyte Epithelial cell of proximal tubule Epithelial cell Smooth muscle cell of the pulmonary artery Skeletal muscle satellite cell Plasmacytoid dendritic cell Precursor b cell Lymphoid lineage restricted progenitor cell Pancreatic a cell Myeloid dendritic cell Enteroendocrine cell Brain pericyte Lymphocyte Lung macrophage Thymocyte Basal cell of epidermis Ependymal cell Endothelial cell of coronary artery Macrophage Intestinal crypt stem cell Microglial cell Fenestrated endothelial cell Pancreatic d cell Kidney collecting duct principal cell Regulatory t cell Pulmonary alveolar type 1 cell Pancreatic stellate cell Myeloid cell Bronchial smooth muscle cell Respiratory basal cell Promonocyte Fibroblast of lung Keratinocyte Hematopoietic stem cell Plasma cell Cd4-positive, alpha-beta t cell Vein endothelial cell Type b pancreatic cell Mesangial cell Interneuron Aortic endothelial cell Mesenchymal stem cell of adipose tissue Granulocytopoietic cell Epidermal cell Pulmonary interstitial fibroblast Bergmann glial cell Keratinocyte stem cell B cell Pericyte Granulocyte monocyte progenitor cell Dn4 thymocyte Professional antigen presenting cell Circulating fibrocyte Neuron Mesenchymal stem cell Immature b cell Megakaryocyte-erythroid progenitor cell Neuroepithelial stem cell Smooth muscle cell of trachea Myeloid leukocyte Regular atrial cardiac myocyte Adventitial cell Monocyte Mucus secreting cell Naive b cell Kidney loop of henle ascending limb epithelial cell Pancreatic ductal cell Large intestine goblet cell Enterocyte of epithelium of large intestine Proerythroblast Astrocyte Basophil Epithelial cell of large intestine Epithelial cell of thymus Regular ventricular cardiac myocyte Fibroblast Early pro-b cell Dendritic cell Fibroblast of cardiac tissue Pulmonary alveolar type 2 cell Medium spiny neuron Non-classical monocyte Basal epithelial cell of tracheobronchial tree Chondrocyte

Aorta Bladder lumen Bone marrow Brain Brown adipose tissue Diaphragm Gonadal fat pad Heart Kidney Large intestine Limb muscle Liver Lung Mammary gland Mesenteric fat pad Pancreas Skin of body Spleen Subcutaneous adipose tissue Thymus Tongue Trachea

3-month-old stage 20-month-old stage and over 18-month-old stage

Normal

Female Male

Smart-seq2

Cell

Homo sapiens

Oligodendrocyte precursor cell Oligodendrocyte Vascular leptomeningeal cell Pvalb chandelier gabaergic interneuron Lamp5 gabaergic interneuron Microglial cell Vip gabaergic interneuron L2/3-6 intratelencephalic projecting glutamatergic neuron L5 extratelencephalic projecting glutamatergic cortical neuron L6b glutamatergic cortical neuron Pvalb gabaergic interneuron Near-projecting glutamatergic cortical neuron Cerebral cortex endothelial cell Caudal ganglionic eminence derived interneuron Sncg gabaergic interneuron Astrocyte of the cerebral cortex Sst gabaergic interneuron Corticothalamic-projecting glutamatergic cortical neuron

Angular gyrus

42-year-old stage Sixth decade stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Neuroblast (sensu nematoda and protostomia)

Basal forebrain Brain Caudate-putamen Cerebellar peduncular complex Cerebellum Cerebral subcortex Choroid plexus epithelium Cortex Diencephalon Dorsal plus ventral thalamus Entorhinal cortex Forebrain Frontal cortex Head Hindbrain Hippocampal formation Hypothalamus Lower layers of the cortex Medulla oblongata Metencephalon Midbrain Midbrain tectum Occipital cortex Pons Striatum Telencephalon Upper layers of the cortex

13th week post-fertilization stage 14th week post-fertilization stage 15th week post-fertilization stage 12th week post-fertilization stage Carnegie stage 20 9th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 22 Carnegie stage 16 Carnegie stage 15 Carnegie stage 18 11th week post-fertilization stage

Normal

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Central memory cd4-positive, alpha-beta t cell Activated cd4-positive, alpha-beta t cell, human Natural killer cell Gamma-delta t cell Lymphocyte Cd4-positive, alpha-beta cytotoxic t cell Naive thymus-derived cd8-positive, alpha-beta t cell Activated cd8-positive, alpha-beta t cell, human Regulatory t cell Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell Double negative thymocyte Cd16-negative, cd56-bright natural killer cell, human Effector memory cd8-positive, alpha-beta t cell

Blood

37-year-old stage 75-year-old stage Sixth decade stage 53-year-old stage 61-year-old stage 54-year-old stage 68-year-old stage 48-year-old stage 39-year-old stage 29-year-old stage 38-year-old stage Fifth decade stage 84-year-old stage 82-year-old stage Third decade stage 80 year-old and over stage 49-year-old stage Seventh decade stage 59-year-old stage 67-year-old stage 62-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 78-year-old stage 36-year-old stage Fourth decade stage 63-year-old stage Eighth decade stage 47-year-old stage 73-year-old stage 27-year-old stage

Covid-19 Normal

Female Male

Seq-well 10x 3' v3 10x 3' v2

Cell

Macaca fascicularis

T cell Neutrophil Erythrocyte Endothelial cell Mast cell Plasmacytoid dendritic cell, human Macrophage Pulmonary alveolar type 1 cell Thymic conventional dendritic cell Plasma cell B cell Fibroblast Pulmonary alveolar type 2 cell

Tuberculosis

Seq-well

Homo sapiens

Amygdala excitatory neuron

Brodmann (1909) area 24 Brodmann (1909) area 25 Brodmann (1909) area 35 Brodmann (1909) area 38 Brodmann (1909) area 40 Brodmann (1909) area 43 Accessory basal amygdaloid nucleus Agranular insular cortex Anterior cortical amygdaloid nucleus Anterior nuclear group Anterior olfactory nucleus Basolateral amygdaloid nuclear complex Bed nucleus of stria terminalis Central amygdaloid nucleus Claustrum of brain Corticomedial nuclear complex Dentate gyrus of hippocampal formation Globus pallidus Gray matter of midbrain Hippocampal field Hypothalamus Lateral amygdaloid nucleus Lateral entorhinal cortex Lateral nuclear group of thalamus Mammillary body Medial dorsal nucleus of thalamus Medial entorhinal cortex Medial geniculate body Median tuberal portion Midbrain tectum Middle temporal gyrus Nucleus accumbens Parabrachial nucleus Perirhinal cortex Piriform cortex Pontine tegmentum Posterior parahippocampal gyrus Preoptic area Pretectal region Primary auditory cortex Primary motor cortex Primary somatosensory cortex Putamen Rostral ca3 Septal nuclear complex Subicular complex Substantia innominata Substantia nigra Superior temporal gyrus Supraoptic nucleus Uncal ca1 Ventral anterior nucleus of thalamus

42-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

T cell Group 3 innate lymphoid cell, human Dendritic cell, human Stromal cell Natural killer cell Endothelial cell Mast cell Plasmacytoid dendritic cell Innate lymphoid cell Plasma cell B cell Cd34-negative, cd117-positive innate lymphoid cell, human Mononuclear phagocyte

Cystic lymph node

61-year-old stage 54-year-old stage 49-year-old stage 59-year-old stage 45-year-old stage 40-year-old stage

Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Oligodendrocyte precursor cell Oligodendrocyte Vascular leptomeningeal cell Microglial cell Cerebral cortex endothelial cell Astrocyte of the cerebral cortex

Angular gyrus Anterior cingulate cortex Dorsolateral prefrontal cortex Middle temporal gyrus Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex

42-year-old stage 43-year-old stage Sixth decade stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Retinal ganglion cell Retinal astrocyte Microglial cell Retinal cone cell Retinal rod cell Retina horizontal cell Amacrine cell Retinal progenitor cell Mueller cell

Central retina Peripheral region of retina Retina

19th week post-fertilization stage 13th week post-fertilization stage 14th week post-fertilization stage 15th week post-fertilization stage 20th week post-fertilization stage 17th week post-fertilization stage 12th week post-fertilization stage 16th week post-fertilization stage 9th week post-fertilization stage Prenatal stage 18th week post-fertilization stage 27th week post-fertilization stage 22nd week post-fertilization stage 24th week post-fertilization stage 11th week post-fertilization stage

Normal

Female Male

10x 3' v1 10x 3' v3 10x 3' v2

Cell