Macaca mulatta

T cell Club cell Granulocyte Multiciliated epithelial cell of the bronchus Mucosal type mast cell Platelet Erythroid lineage cell Smooth muscle cell Pulmonary alveolar type 1 cell Lung endothelial cell Fibroblast of lung B cell Mucosal invariant t cell Myeloid leukocyte Dendritic cell Pulmonary alveolar type 2 cell

Lung

Late embryonic stage

Normal

Female Male

10x 3' v3

Cell

Mus musculus

Cell Oligodendrocyte precursor cell Oligodendrocyte Brain pericyte Microglial cell Endothelial stalk cell Neuron Astrocyte Fibroblast

Normal

10x 3' v3

Homo sapiens

Fibroblast

Cranial nerve ii Optic disc

69-year-old stage 37-year-old stage 75-year-old stage 21-year-old stage 34-year-old stage 65-year-old stage 42-year-old stage 43-year-old stage 71-year-old stage 85-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 54-year-old stage 68-year-old stage 30-year-old stage 17-year-old stage 56-year-old stage 15-year-old stage 82-year-old stage 50-year-old stage 72-year-old stage 81-year-old stage 74-year-old stage 16-year-old stage 58-year-old stage 25-year-old stage 67-year-old stage 90 year-old and over stage 3-year-old stage 32-year-old stage 77-year-old stage 33-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 18-year-old stage Newborn stage (0-28 days) 63-year-old stage 47-year-old stage 76-year-old stage 11-year-old stage 27-year-old stage 10-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Cell in vitro

Endometrium

28-year-old stage Young adult stage

Normal

10x 3' v3

Cell

Homo sapiens

Glutamatergic neuron Glial cell Gabaergic neuron Neural progenitor cell

Primary visual cortex Orbitofrontal cortex Caudal ganglionic eminence Parietal lobe Medial ganglionic eminence Hippocampal formation Anterior cingulate cortex

22nd week post-fertilization stage

Normal

Drop-seq

Cell

Homo sapiens

T cell Adipocyte of breast Endothelial cell of lymphatic vessel Mast cell Basal cell Luminal epithelial cell of mammary gland Endothelial cell of vascular tree Myeloid cell Pericyte Fibroblast

Breast

Adult stage Prime adult stage

Normal

Female

10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

Neutrophil Activated cd4-positive, alpha-beta t cell, human Cd14-positive, cd16-positive monocyte Natural killer cell Gamma-delta t cell Endothelial cell Mature nk t cell Mast cell Cd8-positive, alpha-beta t cell Cd141-positive myeloid dendritic cell Plasmacytoid dendritic cell Lymphocyte Lung macrophage Cd8-positive, alpha-beta cytotoxic t cell Naive thymus-derived cd8-positive, alpha-beta t cell Macrophage Cd4-positive type i nk t cell secreting interferon-gamma Cd4-positive, cd25-positive, alpha-beta regulatory t cell Innate lymphoid cell Fibroblast of lung Cd38-positive naive b cell Plasma cell Cd4-positive, alpha-beta t cell Cd14-positive monocyte Cycling mononuclear phagocyte B cell Naive thymus-derived cd4-positive, alpha-beta t cell Epithelial cell of lung Conventional dendritic cell Lung pericyte

Lung parenchyma

66-year-old stage 69-year-old stage 68-year-old stage 56-year-old stage 72-year-old stage 58-year-old stage 67-year-old stage 64-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 63-year-old stage 76-year-old stage 73-year-old stage

Lung adenocarcinoma

Female Male

10x 3' v3

Cell

Homo sapiens

Angiogenic pericyte Interstitial cell of cajal Smooth muscle cell Mesodermal cell Gastrointestinal tract (lamina propria) macrophage Mesothelial cell Pericyte Fibroblast

Stomach Duodenum Small intestine Ileum Colon Jejunum

Carnegie stage 19 13th week post-fertilization stage 12th week post-fertilization stage 9th week post-fertilization stage 10th week post-fertilization stage Embryonic stage Carnegie stage 17 Carnegie stage 22 Carnegie stage 16 Carnegie stage 18 11th week post-fertilization stage

Normal

Female Male

10x 5' v2 10x 3' v3 10x 3' v2

Cell

Homo sapiens

T cell Club cell Ciliated cell Natural killer cell Pulmonary alveolar epithelial cell Pulmonary capillary endothelial cell Lymphatic endothelial cell of trabecula Endothelial cell of artery Smooth muscle cell Goblet cell Macrophage Pulmonary alveolar type 1 cell Respiratory basal cell Fibroblast of lung Vein endothelial cell of respiratory system Mesothelial cell B cell Monocyte Myofibroblast cell Dendritic cell Cd16-negative, cd56-bright natural killer cell, human Pulmonary alveolar type 2 cell

Lung

66-year-old stage 71-year-old stage 61-year-old stage 68-year-old stage 44-year-old stage 50-year-old stage 51-year-old stage 72-year-old stage 35-year-old stage 62-year-old stage 60-year-old stage 31-year-old stage 40-year-old stage

Normal

Female Male

10x multiome

Nucleus

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Amygdala excitatory neuron Committed oligodendrocyte precursor Dentate gyrus granule cell Cerebellar granule cell Hippocampal ca1-3 neuron Lamp5 lhx6 neuron Eccentric medium spiny neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Cerebellar inhibitory gabaergic interneuron Microglial cell Thalamic excitatory neuron Choroid plexus epithelial cell Pericyte Cerebral cortex neuron Near-projecting glutamatergic cortical neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Unipolar brush cell Fibroblast Medium spiny neuron Mammillary body neuron Hippocampal ca4 neuron

Primary motor cortex

42-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Tracheobronchial smooth muscle cell Club cell Natural killer cell Mesothelial fibroblast Endothelial cell Mast cell Cd8-positive, alpha-beta t cell Lung goblet cell Endothelial cell of artery Capillary endothelial cell Epithelial cell Lung multiciliated epithelial cell Brush cell of tracheobronchial tree Macrophage Regulatory t cell Respiratory basal cell Alveolar macrophage Plasma cell Cd4-positive, alpha-beta t cell Vein endothelial cell Alveolar adventitial fibroblast B cell Pericyte Neuron Monocyte Mucus secreting cell Vascular associated smooth muscle cell Fibroblast Dendritic cell Pulmonary alveolar type 2 cell

Lung

69-year-old stage 75-year-old stage 65-year-old stage 71-year-old stage 68-year-old stage 84-year-old stage 80-year-old stage 72-year-old stage 58-year-old stage 70-year-old stage 78-year-old stage 63-year-old stage 79-year-old stage 73-year-old stage 83-year-old stage

Covid-19 Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Pvalb gabaergic interneuron

Dorsolateral prefrontal cortex

69-year-old stage 75-year-old stage 42-year-old stage 89-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 77-year-old stage 86-year-old stage 70-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus