Homo sapiens

Mesothelial cell Interstitial cell of cajal Mesodermal cell Fibroblast Angiogenic pericyte Pericyte Smooth muscle cell Gastrointestinal tract (lamina propria) macrophage

Ileum Small intestine Jejunum Duodenum Colon Stomach

9th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 22 Embryonic stage 11th week post-fertilization stage Carnegie stage 19 Carnegie stage 17 Carnegie stage 18 Carnegie stage 16

Normal

Female Male

10x 5' v2 10x 3' v3 10x 3' v2

Cell

Homo sapiens

Lymphatic endothelial cell of trabecula Myofibroblast cell Pulmonary alveolar type 1 cell Pulmonary alveolar type 2 cell Club cell Macrophage Vein endothelial cell of respiratory system Mesothelial cell Cd16-negative, cd56-bright natural killer cell, human Monocyte B cell Dendritic cell Pulmonary capillary endothelial cell Pulmonary alveolar epithelial cell T cell Fibroblast of lung Smooth muscle cell Respiratory basal cell Natural killer cell Endothelial cell of artery Ciliated cell Goblet cell

Lung

66-year-old stage 50-year-old stage 62-year-old stage 60-year-old stage 44-year-old stage 40-year-old stage 71-year-old stage 31-year-old stage 68-year-old stage 61-year-old stage 51-year-old stage 35-year-old stage 72-year-old stage

Normal

Female Male

10x multiome

Nucleus

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Pericyte Endothelial cell Neuron Central nervous system macrophage Choroid plexus epithelial cell

Primary motor cortex

50-year-old stage 60-year-old stage 42-year-old stage 29-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Capillary endothelial cell Cd4-positive, alpha-beta t cell Pulmonary alveolar type 2 cell Club cell Macrophage Alveolar macrophage Brush cell of tracheobronchial tree Lung goblet cell Mast cell Tracheobronchial smooth muscle cell Epithelial cell Monocyte Lung multiciliated epithelial cell Vein endothelial cell Vascular associated smooth muscle cell Fibroblast Pericyte Endothelial cell B cell Cd8-positive, alpha-beta t cell Dendritic cell Plasma cell Regulatory t cell Mucus secreting cell Alveolar adventitial fibroblast Respiratory basal cell Neuron Natural killer cell Mesothelial fibroblast Endothelial cell of artery

Lung

80-year-old stage 79-year-old stage 70-year-old stage 65-year-old stage 75-year-old stage 71-year-old stage 78-year-old stage 63-year-old stage 58-year-old stage 68-year-old stage 72-year-old stage 73-year-old stage 84-year-old stage 69-year-old stage 83-year-old stage

Normal Covid-19

Female Male

10x 3' v3

Nucleus

Homo sapiens

Pvalb gabaergic interneuron

Dorsolateral prefrontal cortex

80-year-old stage 85-year-old stage 82-year-old stage 70-year-old stage 77-year-old stage 50-year-old stage 86-year-old stage 80 year-old and over stage 89-year-old stage 75-year-old stage 78-year-old stage 68-year-old stage 42-year-old stage 72-year-old stage 88-year-old stage 84-year-old stage 69-year-old stage 29-year-old stage 87-year-old stage 81-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x 3' v3 10x multiome

Nucleus

Homo sapiens

Bronchus fibroblast of lung Schwann cell Serous secreting cell of bronchus submucosal gland Pulmonary alveolar type 1 cell Endothelial cell of lymphatic vessel Cd4-positive, alpha-beta t cell Pulmonary alveolar type 2 cell Pulmonary neuroendocrine cell Lung microvascular endothelial cell Lung resident memory cd8-positive, alpha-beta t cell Macrophage Vein endothelial cell of respiratory system Mast cell Alternatively activated macrophage Multiciliated columnar cell of tracheobronchial tree Neutrophil Monocyte Blood vessel smooth muscle cell Respiratory tract goblet cell Tracheobronchial serous cell Vascular associated smooth muscle cell Conventional dendritic cell Fibroblast Bronchiolar smooth muscle cell Pericyte Deuterosomal cell B cell Cd8-positive, alpha-beta t cell Plasma cell Pulmonary capillary endothelial cell Mature nk t cell T cell Plasmacytoid dendritic cell Myoepithelial cell of bronchus submucosal gland Mucus secreting cell of bronchus submucosal gland Fibroblast of lung Respiratory basal cell Pulmonary ionocyte Natural killer cell Chondrocyte Endothelial cell of artery Serous cell of epithelium of lobular bronchiole Respiratory tract suprabasal cell

Bronchus Segmental bronchus Terminal bronchus

66-year-old stage 32-year-old stage 57-year-old stage 65-year-old stage 67-year-old stage 37-year-old stage 63-year-old stage 20-year-old stage 56-year-old stage 58-year-old stage 61-year-old stage 24-year-old stage 12-year-old stage 39-year-old stage 41-year-old stage 11-year-old stage

Normal Chronic obstructive pulmonary disease

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Igg plasma cell Glial cell Iga plasma cell Mast cell Epithelial cell Fibroblast Myeloid leukocyte B cell T cell Gut endothelial cell Igm plasma cell

Functional gastric disease

10x 3' v2

Homo sapiens

Endothelial cell

Interventricular septum Apex of heart Heart left ventricle Heart right ventricle

Fourth decade stage Postnatal stage Eighth decade stage Fifth decade stage Pediatric stage Seventh decade stage Third decade stage Sixth decade stage

Normal Dilated cardiomyopathy Non-compaction cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy

Female Male

10x 3' v3 10x 3' v2

Nucleus

Mus musculus

Cerebellar granule cell Unipolar brush cell Brain vascular cell Cerebellar granule cell precursor Glutamatergic neuron Oligodendrocyte Gabaergic neuron Meningeal macrophage Neuroblast (sensu vertebrata) Noradrenergic cell Immature astrocyte Erythroid lineage cell Bergmann glial cell Interneuron Microglial cell Motor neuron Macroglial cell Ependymal cell Purkinje cell Central nervous system macrophage Glioblast

Cerebellar hemisphere Cerebellum

Theiler stage 23 Theiler stage 21 Theiler stage 25 4-day-old stage 7-day-old stage Theiler stage 18 Theiler stage 20 Theiler stage 27 2-month-old stage 2-week-old stage Theiler stage 22

Normal

Female Male

10x 3' v3 10x 3' v2

Nucleus

Mus musculus

Cell

Normal

Mixed sex

10x 3' v2

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron Caudal ganglionic eminence derived interneuron Cerebral cortex endothelial cell Vascular leptomeningeal cell Oligodendrocyte precursor cell Oligodendrocyte Astrocyte of the cerebral cortex Sncg gabaergic interneuron Near-projecting glutamatergic cortical neuron Sst gabaergic interneuron Microglial cell Lamp5 gabaergic interneuron L6b glutamatergic cortical neuron Corticothalamic-projecting glutamatergic cortical neuron L5 extratelencephalic projecting glutamatergic cortical neuron Vip gabaergic interneuron Pvalb gabaergic interneuron Pvalb chandelier gabaergic interneuron

Primary motor cortex

50-year-old stage 60-year-old stage 42-year-old stage 29-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Brown adipocyte Adipocyte Brown preadipocyte

Embryo

Theiler stage 23 Theiler stage 24 Theiler stage 25 Theiler stage 26 Theiler stage 20 Theiler stage 27 Theiler stage 22

Normal

Female Male

Sci-rna-seq3

Nucleus