Homo sapiens

Pyramidal neuron Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Microglial cell Interneuron Cerebral cortex neuron Astrocyte

Hippocampal formation

37-year-old stage 26-year-old stage 44-year-old stage 24-year-old stage 60-year-old stage

Epilepsy

Female Male

10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

Lamp5 gabaergic interneuron Vip gabaergic interneuron Caudal ganglionic eminence derived interneuron Sncg gabaergic interneuron

Dorsolateral prefrontal cortex Primary visual cortex Middle temporal gyrus Primary somatosensory cortex Primary auditory cortex Primary motor cortex Anterior cingulate cortex Angular gyrus

42-year-old stage 43-year-old stage Sixth decade stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

T cell Neutrophil Stromal cell Natural killer cell Erythrocyte Endothelial cell Mature nk t cell Hematopoietic precursor cell Mast cell Cd8-positive, alpha-beta t cell Classical monocyte Intermediate monocyte Plasmacytoid dendritic cell Myeloid dendritic cell Macrophage Innate lymphoid cell Regulatory t cell Plasma cell Cd4-positive, alpha-beta t cell Cd8-positive, alpha-beta thymocyte Cd4-positive, alpha-beta thymocyte B cell Naive thymus-derived cd4-positive, alpha-beta t cell Monocyte Non-classical monocyte

Inguinal lymph node Lymph node Mesenteric lymph node

69-year-old stage 61-year-old stage 56-year-old stage 59-year-old stage 45-year-old stage 60-year-old stage

Normal

Female Male

10x 5' v2 Smart-seq2 10x 3' v3

Cell

Homo sapiens

T cell Mature nk t cell Pro-b cell Plasmacytoid dendritic cell Precursor b cell Common dendritic progenitor Mature b cell Hematopoietic stem cell Plasma cell Hematopoietic multipotent progenitor cell Granulocyte monocyte progenitor cell Common lymphoid progenitor Immature b cell Megakaryocyte-erythroid progenitor cell Monocyte Conventional dendritic cell Early pro-b cell

Blood

3-month-old stage 9-month-old stage 6-month-old stage 10-month-old stage 2-month-old stage 8-month-old stage 1-month-old stage Newborn stage (0-28 days) 4-month-old stage 11-month-old stage 7-month-old stage

B-cell acute lymphoblastic leukemia

Female Male

10x 3' v3

Cell

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Middle temporal gyrus

69-year-old stage 75-year-old stage 65-year-old stage 89-year-old stage 43-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage Adult stage 77-year-old stage 86-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

T cell Neutrophil Natural killer cell Endothelial cell of lymphatic vessel Endothelial cell Mast cell Smooth muscle cell Macrophage Subcutaneous adipocyte B cell Mesenchymal stem cell of abdominal adipose tissue Pericyte Monocyte Dendritic cell

Normal

10x 3' v3

Homo sapiens

Midbrain-derived inhibitory neuron

Subthalamic nucleus Medial geniculate body Lateral amygdaloid nucleus Anterior nuclear group Corticomedial nuclear complex Pontine reticular formation Centromedian nucleus of thalamus Intralaminar nuclear group Medial dorsal nucleus of thalamus Parabrachial nucleus Nucleus of medulla oblongata Red nucleus Pontine tegmentum Pontine nuclear group Globus pallidus Midbrain nucleus Lateral nuclear group of thalamus Central amygdaloid nucleus Ventral anterior nucleus of thalamus Septal nuclear complex Cerebellar nuclear complex Median tuberal portion Epithalamus Dorsal tegmental nucleus Midbrain tectum Inferior olivary complex Substantia nigra Gray matter of midbrain Substantia innominata Anterior olfactory nucleus Accessory basal amygdaloid nucleus Pulvinar nucleus Hypothalamus Primary motor cortex Medial zone of hypothalamus Basolateral amygdaloid nuclear complex Spinal cord Dentate gyrus of hippocampal formation Lateral posterior nucleus of thalamus Mammillary body Bed nucleus of stria terminalis Lateral geniculate body Pretectal region Nucleus of dorsal thalamus Preoptic area

42-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Melanocyte Olfactory ensheathing cell Perineuronal satellite cell Myelinating schwann cell Schwann cell precursor

Embryo

Theiler stage 22 Theiler stage 27 Theiler stage 24 Theiler stage 18 Theiler stage 25 Theiler stage 14 Theiler stage 16 Theiler stage 17 Theiler stage 15 Theiler stage 19 Theiler stage 26 Theiler stage 13 Theiler stage 20 Theiler stage 12 Theiler stage 21 Theiler stage 23

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Endothelial cell Oligodendrocyte Lymphocyte Myeloid cell Neoplastic cell Pericyte

Glioblastoma Diffuse glioma, h3 g34 mutant Oligodendroglioma, idh-mutant and 1p/19q-codeleted, grade 3

Single-cell rna sequencing

Macaca fascicularis

Oligodendrocyte precursor cell Oligodendrocyte Ependymal cell Microglial cell Endothelial stalk cell Interneuron Neuron Astrocyte Fibroblast

Normal

10x 3' v3

Homo sapiens

Osteoblast Muscle cell Natural killer cell Endothelial cell of lymphatic vessel Erythrocyte Fibroblast of dermis Mast cell Peridermal cell Hypertrophic chondrocyte Tendon cell Basal cell Endothelial cell of artery Schwann cell Melanocyte Smooth muscle cell Articular chondrocyte Connective tissue cell Early lymphoid progenitor Primitive red blood cell Chondroblast Macrophage Myelocyte Common myeloid progenitor Vein endothelial cell Mesenchymal cell Megakaryocyte Skeletal muscle myoblast Myoblast B cell Pericyte Neuron Reticulocyte Monocyte Conventional dendritic cell Fibroblast Schwann cell precursor Chondrocyte Muscle fibroblast

Hindlimb Forelimb

Carnegie stage 19 9th week post-fertilization stage Carnegie stage 23 10th week post-fertilization stage Carnegie stage 17 Carnegie stage 16 Carnegie stage 15 Carnegie stage 18

Normal

Female Male

10x 5' v1 10x 3' v2

Cell

Homo sapiens

Neutrophil Club cell Dendritic cell, human Stromal cell Natural killer cell Erythrocyte Pulmonary capillary endothelial cell Gamma-delta t cell Myeloid dendritic cell, human Mature nk t cell Mast cell Cd8-positive, alpha-beta t cell Pancreatic acinar cell Basal cell Smooth muscle cell Intermediate monocyte Plasmacytoid dendritic cell, human Lung multiciliated epithelial cell Lung macrophage Regulatory t cell Pulmonary alveolar type 1 cell Lung endothelial cell Fibroblast of lung Plasma cell Cd4-positive, alpha-beta t cell Mesothelial cell B cell Epithelial cell of lung Pulmonary alveolar type 2 cell Lung pericyte Non-classical monocyte

Lower lobe of left lung

57-year-old stage

Covid-19

Male

10x 3' v3 10x 3' v2

Cell