Homo sapiens

Retinal rod cell Glial cell Retinal cone cell Retinal bipolar neuron Amacrine cell Retina horizontal cell

Peripheral region of retina Fovea centralis Macula lutea proper

65-year-old stage 78-year-old stage 73-year-old stage 84-year-old stage 83-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Microcebus murinus

Pancreatic endocrine cell Kidney loop of henle thick ascending limb epithelial cell Osteoblast Myofibroblast cell Retinal rod cell Slow muscle cell Thyrotroph Pancreatic ductal cell Pulmonary alveolar type 1 cell Capillary endothelial cell Glutamatergic neuron Basal cell of epithelium of trachea Endothelial cell of hepatic sinusoid Mesenchymal stem cell Erythroid progenitor cell Astrocyte Innate lymphoid cell Oligodendrocyte precursor cell Cardiac muscle cell Small intestine goblet cell Endothelial cell of lymphatic vessel Megakaryocyte progenitor cell Oligodendrocyte Cd4-positive, alpha-beta t cell Pulmonary alveolar type 2 cell Mesothelial cell of epicardium Gabaergic neuron Endothelial cell of sinusoid Club cell Platelet Retinal cone cell Lymphocyte Macrophage Pancreatic acinar cell Myelinating schwann cell Skeletal muscle satellite stem cell Mesothelial cell Kidney distal convoluted tubule epithelial cell Alveolar macrophage Granulocyte monocyte progenitor cell Enterocyte of epithelium of large intestine Off-bipolar cell Stromal cell Interstitial cell of cajal Spermatocyte Kidney loop of henle thin descending limb epithelial cell Epithelial cell Type b pancreatic cell Brush cell of bronchus Erythroid lineage cell Adipocyte Pancreatic d cell On-bipolar cell Neutrophil Mammotroph Brush cell of trachea Macula densa epithelial cell Non-myelinating schwann cell Epithelial cell of sweat gland Monocyte Tendon cell Epithelial cell of uterus Vasa recta ascending limb cell Renal beta-intercalated cell Enterocyte of epithelium of small intestine Basal cell of epidermis Renal principal cell Epithelial cell of small intestine Leptomeningeal cell Intrahepatic cholangiocyte Epithelial cell of proximal tubule Vein endothelial cell Purkinje myocyte Kidney collecting duct intercalated cell Preosteoblast Bladder urothelial cell Regular atrial cardiac myocyte Vascular associated smooth muscle cell Conventional dendritic cell Fibroblast Renal intercalated cell Hepatocyte Podocyte Intestinal tuft cell Urothelial cell Hematopoietic precursor cell Ependymal cell Corticotroph Pericyte Endothelial cell Regular ventricular cardiac myocyte Pancreatic pp cell Pancreatic a cell Kidney loop of henle epithelial cell B cell Epidermal cell Somatotroph Cd8-positive, alpha-beta t cell Mueller cell Retinal bipolar neuron Oral mucosa squamous cell Kidney proximal straight tubule epithelial cell Dendritic cell Plasma cell Mature nk t cell T cell Vasa recta descending limb cell Plasmacytoid dendritic cell Hair follicle cell Secretory cell Spermatid Granulosa cell Neuroendocrine cell Kidney proximal convoluted tubule epithelial cell Renal alpha-intercalated cell Glomerular endothelial cell Fibroblast of lung Smooth muscle cell Basophil Neuron Eosinophil Spermatogonium Large intestine goblet cell Epithelial cell of large intestine Epithelial cell of exocrine pancreas Retina horizontal cell Natural killer cell Chondrocyte Endothelial cell of artery Gonadtroph Reticular cell Choroid plexus epithelial cell Melanocyte Ciliated cell Langerhans cell Nodal myocyte M cell of gut Fast muscle cell Myeloid cell Basal cell of epithelium of bronchus Intestinal enteroendocrine cell Kidney loop of henle thin ascending limb epithelial cell

Cardiac muscle tissue Epithelium of tongue Blood Uterus Thymus Liver Spleen Brown adipose tissue Testis Heart left ventricle Lung Small intestine Tongue muscle Gonadal fat pad Mesenteric fat pad Trachea Mammary gland Kidney Left cardiac atrium Pancreas Limb bone Aorta Urinary bladder Adipose tissue Tongue Subcutaneous adipose tissue Right cardiac atrium Diaphragm Cerebral cortex Bone element Vertebral column Limb muscle Retina Colon Bone marrow Heart right ventricle Skin of body Brainstem Hypothalamus-pituitary axis Heart

Post-juvenile adult stage

Normal

Female Male

Smart-seq2 10x 3' v2

Cell

Homo sapiens

Malignant cell

Breast

80-year-old stage 85-year-old stage 82-year-old stage 66-year-old stage 79-year-old stage 70-year-old stage 32-year-old stage 50-year-old stage 57-year-old stage 62-year-old stage Prime adult stage 46-year-old stage 52-year-old stage 60-year-old stage 60-79 year-old stage 80 year-old and over stage 64-year-old stage 45-year-old stage 25-year-old stage 65-year-old stage 67-year-old stage Middle aged stage Eighth decade stage 37-year-old stage 71-year-old stage Adult stage Ninth decade stage 36-year-old stage 63-year-old stage 59-year-old stage 54-year-old stage Fifth decade stage 47-year-old stage 58-year-old stage 61-year-old stage 34-year-old stage 49-year-old stage 42-year-old stage 35-year-old stage 73-year-old stage 30-year-old stage Seventh decade stage 88-year-old stage 84-year-old stage 69-year-old stage 43-year-old stage Late adult stage 29-year-old stage 38-year-old stage 41-year-old stage 55-year-old stage 83-year-old stage Sixth decade stage

Breast cancer Invasive ductal breast carcinoma Breast mucinous carcinoma Her2 positive breast carcinoma Triple-negative breast carcinoma Invasive lobular breast carcinoma Estrogen-receptor positive breast cancer Metaplastic breast carcinoma Invasive tubular breast carcinoma Breast carcinoma Breast apocrine carcinoma

Female Male

10x 5' v2 10x 5' v1 10x 3' v3 10x 5' transcription profiling 10x 3' v2

Cell

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron Caudal ganglionic eminence derived interneuron Cerebral cortex endothelial cell Vascular leptomeningeal cell Oligodendrocyte precursor cell Oligodendrocyte Astrocyte of the cerebral cortex Sncg gabaergic interneuron Near-projecting glutamatergic cortical neuron Sst gabaergic interneuron Microglial cell Lamp5 gabaergic interneuron L6b glutamatergic cortical neuron Corticothalamic-projecting glutamatergic cortical neuron L5 extratelencephalic projecting glutamatergic cortical neuron Vip gabaergic interneuron Pvalb gabaergic interneuron Pvalb chandelier gabaergic interneuron

Primary visual cortex

50-year-old stage 60-year-old stage 42-year-old stage 43-year-old stage 29-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Basal cell Luminal epithelial cell of mammary gland Mammary gland epithelial cell

Breast

Prime adult stage Adult stage

Normal

Female

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Pro-b cell B-1 b cell Common myeloid progenitor Promonocyte Innate lymphoid cell Double-positive, alpha-beta thymocyte Large pre-b-ii cell Mature b cell Naive thymus-derived cd4-positive, alpha-beta t cell Granulocyte monocyte progenitor cell Late pro-b cell Promyelocyte Small pre-b-ii cell Megakaryocyte-erythroid progenitor cell Fraction a pre-pro b cell Megakaryocyte Immature b cell Double negative thymocyte B-2 b cell Early lymphoid progenitor Naive thymus-derived cd8-positive, alpha-beta t cell Group 3 innate lymphoid cell Hematopoietic stem cell Cd8-alpha-alpha-positive, alpha-beta intraepithelial t cell Group 2 innate lymphoid cell Plasma cell Regulatory t cell T cell Natural killer cell Hematopoietic multipotent progenitor cell

Thymus Mesenteric lymph node Liver Spleen Kidney Bone marrow Gut wall Yolk sac Skin of body

9th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 22 11th week post-fertilization stage 17th week post-fertilization stage 15th week post-fertilization stage Carnegie stage 19 Carnegie stage 13 14th week post-fertilization stage 16th week post-fertilization stage Carnegie stage 23 Carnegie stage 20

Normal

Female Male

10x 5' v1 10x 3' v2

Cell

Homo sapiens

Activated cd4-positive, alpha-beta t cell, human Naive b cell Classical monocyte Platelet Non-classical monocyte Lymphocyte Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell Transitional stage b cell Cd16-negative, cd56-bright natural killer cell, human Neutrophil Double negative thymocyte Plasmablast Conventional dendritic cell Naive thymus-derived cd8-positive, alpha-beta t cell Central memory cd4-positive, alpha-beta t cell Effector memory cd8-positive, alpha-beta t cell Hematopoietic stem cell Cd4-positive, alpha-beta cytotoxic t cell Plasmacytoid dendritic cell, human Igg plasmablast Erythrocyte Regulatory t cell Memory b cell Activated cd8-positive, alpha-beta t cell, human Iga plasmablast Natural killer cell Gamma-delta t cell Immature neutrophil

Blood

82-year-old stage 70-year-old stage Fourth decade stage 62-year-old stage 46-year-old stage 60-year-old stage 80 year-old and over stage 48-year-old stage 67-year-old stage Eighth decade stage 75-year-old stage 27-year-old stage 37-year-old stage Adult stage 78-year-old stage 36-year-old stage 63-year-old stage 59-year-old stage 54-year-old stage Fifth decade stage 47-year-old stage 68-year-old stage 61-year-old stage 49-year-old stage 53-year-old stage 73-year-old stage Seventh decade stage 84-year-old stage 39-year-old stage Third decade stage 29-year-old stage 38-year-old stage Sixth decade stage

Normal Covid-19

Female Male

10x 3' v3 Seq-well 10x 3' v2

Cell

Homo sapiens

Naive b cell Basal cell of epithelium of trachea Innate lymphoid cell Cd4-positive, alpha-beta memory t cell Cd4-positive, alpha-beta t cell Club cell Macrophage Mucosal invariant t cell Mast cell Alternatively activated macrophage Tracheal goblet cell Duct epithelial cell Cd16-negative, cd56-bright natural killer cell, human Naive t cell Neutrophil Brush cell of trachea Monocyte Cd8-positive, alpha-beta memory t cell Conventional dendritic cell Multiciliated epithelial cell Follicular dendritic cell B cell Plasmacytoid dendritic cell, human Squamous epithelial cell Dendritic cell Plasma cell Regulatory t cell Mature nk t cell T cell Memory b cell Secretory cell Neuroendocrine cell T follicular helper cell Pulmonary ionocyte Gamma-delta t cell Melanocyte Ciliated cell Cd16-positive, cd56-dim natural killer cell, human Langerhans cell

Bronchus Trachea Nasal cavity

70-year-old stage 76-year-old stage 52-year-old stage Juvenile stage (5-14 yo) 25-year-old stage Postnatal stage Adult stage 56-year-old stage Pediatric stage 73-year-old stage 39-year-old stage Newborn stage (0-28 days) Late adult stage Child stage (1-4 yo)

Normal Covid-19

Female Male

10x 5' v2 10x 5' v1

Cell

Callithrix jacchus

Glutamatergic neuron

Dorsolateral prefrontal cortex Brodmann (1909) area 25 Prefrontal cortex

Prime adult stage Late adult stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Myofibroblast cell Slow muscle cell Schwann cell Mural cell Mesenchymal stem cell Glial cell Muscle cell Skeletal muscle satellite stem cell Stromal cell Ventricular cardiac muscle cell Fibroblast of breast Adipocyte Thymic fibroblast type 2 Tendon cell Myometrial cell Blood vessel smooth muscle cell Keratocyte Stromal cell of ovary Leydig cell Regular atrial cardiac myocyte Vascular associated smooth muscle cell Fibroblast Pericyte Pancreatic stellate cell Adventitial cell Mesenchymal cell Mueller cell Hepatic stellate cell Bronchial smooth muscle cell Connective tissue cell Fibroblast of cardiac tissue Mesenchymal stem cell of adipose tissue Theca cell Thymic fibroblast type 1 Alveolar adventitial fibroblast Smooth muscle cell Tongue muscle cell Melanocyte Fast muscle cell

Posterior part of tongue Posterior segment of eyeball Submandibular gland Stomach smooth muscle Anterior segment of eyeball Coronary artery Ileum Uterus Thymus Vasculature Mesenteric lymph node Liver Skin of abdomen Spleen Parotid gland Brown adipose tissue Testis Right ovary Bladder organ Sublingual gland Lung Inferior vena cava Small intestine Abdominal aorta Ovary Muscle of abdomen Trachea Mammary gland Muscle of pelvic diaphragm Mucosa of stomach Inguinal lymph node Endometrium Sclera Utricle of membranous labyrinth Jejunum Cardiac ventricle Aorta Muscularis mucosae of stomach Adipose tissue Tongue Crista ampullaris Subcutaneous adipose tissue Prostate gland Right cardiac atrium Cardiac atrium Skin of chest Retinal neural layer Conjunctiva Eyelid Eye Chorioretinal region Sigmoid colon Cornea Duodenum Lacrimal gland Myometrium Left coronary artery Bone marrow Thoracic aorta Endocrine pancreas Left ovary Ascending colon Stomach Exocrine pancreas Heart right ventricle Skin of body Buccal mucosa Ocular surface region Anterior part of tongue Heart Large intestine Lymph node

57-year-old stage 46-year-old stage 60-year-old stage 45-year-old stage 74-year-old stage 33-year-old stage 67-year-old stage 40-year-old stage 37-year-old stage 36-year-old stage 59-year-old stage 56-year-old stage 61-year-old stage 26-year-old stage 69-year-old stage 38-year-old stage 55-year-old stage

Normal

Female Male

Smart-seq2 10x 5' v2 10x 3' v3 Smart-seq3

Cell

Homo sapiens

L2/3 intratelencephalic projecting glutamatergic neuron L6 intratelencephalic projecting glutamatergic neuron Caudal ganglionic eminence derived interneuron Brain vascular cell Glutamatergic neuron Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Gabaergic neuron Medial ganglionic eminence derived gabaergic interneuron Immature astrocyte Sncg gabaergic interneuron Committed oligodendrocyte precursor Near-projecting glutamatergic cortical neuron Neural progenitor cell Intratelencephalic-projecting glutamatergic cortical neuron Sst gabaergic interneuron L5 intratelencephalic projecting glutamatergic neuron Microglial cell Lamp5 gabaergic interneuron L6b glutamatergic cortical neuron Corticothalamic-projecting glutamatergic cortical neuron L4 intratelencephalic projecting glutamatergic neuron Forebrain radial glial cell Cajal-retzius cell L5 extratelencephalic projecting glutamatergic cortical neuron Vip gabaergic interneuron Pvalb gabaergic interneuron

Forebrain Brodmann (1909) area 17 Telencephalon Brodmann (1909) area 10 Neocortex Brodmann (1909) area 9 Visual cortex Prefrontal cortex

9th week post-fertilization stage 34th week post-fertilization stage 3-month-old stage 13th week post-fertilization stage 12th week post-fertilization stage 5-month-old stage 33rd week post-fertilization stage 31st week post-fertilization stage 26th week post-fertilization stage 11th week post-fertilization stage 21st week post-fertilization stage 14th week post-fertilization stage 7-month-old stage 16th week post-fertilization stage 9-month-old stage 13-year-old stage 18th week post-fertilization stage Carnegie stage 23 Carnegie stage 21 32nd week post-fertilization stage

Normal

Female Male

10x multiome

Nucleus

Homo sapiens

B cell

Ulcerative colitis

10x 5' v1