Homo sapiens

T cell Neutrophil Club cell Ciliated cell Follicular dendritic cell Secretory cell Gamma-delta t cell Basal cell of epithelium of trachea Neuroendocrine cell Mature nk t cell Mast cell Pulmonary ionocyte Melanocyte Plasmacytoid dendritic cell, human Alternatively activated macrophage Cd8-positive, alpha-beta memory t cell Macrophage Memory b cell Cd16-positive, cd56-dim natural killer cell, human Innate lymphoid cell Regulatory t cell Duct epithelial cell Plasma cell Cd4-positive, alpha-beta t cell Langerhans cell Squamous epithelial cell T follicular helper cell Cd4-positive, alpha-beta memory t cell Tracheal goblet cell B cell Naive t cell Mucosal invariant t cell Monocyte Naive b cell Multiciliated epithelial cell Conventional dendritic cell Dendritic cell Cd16-negative, cd56-bright natural killer cell, human Brush cell of trachea

Bronchus Nasal cavity Trachea

Pediatric stage 52-year-old stage 39-year-old stage 56-year-old stage 25-year-old stage Adult stage Late adult stage Postnatal stage 70-year-old stage Newborn stage (0-28 days) 76-year-old stage 73-year-old stage Child stage (1-4 yo) Juvenile stage (5-14 yo)

Covid-19 Normal

Female Male

10x 5' v2 10x 5' v1

Cell

Callithrix jacchus

Glutamatergic neuron

Brodmann (1909) area 25 Dorsolateral prefrontal cortex Prefrontal cortex

Late adult stage Prime adult stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Fast muscle cell Muscle cell Stromal cell Thymic fibroblast type 1 Slow muscle cell Stromal cell of ovary Blood vessel smooth muscle cell Tendon cell Myometrial cell Schwann cell Melanocyte Smooth muscle cell Thymic fibroblast type 2 Connective tissue cell Hepatic stellate cell Adipocyte Mural cell Pancreatic stellate cell Bronchial smooth muscle cell Ventricular cardiac muscle cell Tongue muscle cell Fibroblast of breast Glial cell Mesenchymal cell Alveolar adventitial fibroblast Mesenchymal stem cell of adipose tissue Pericyte Mueller cell Skeletal muscle satellite stem cell Mesenchymal stem cell Regular atrial cardiac myocyte Adventitial cell Vascular associated smooth muscle cell Myofibroblast cell Leydig cell Fibroblast Theca cell Fibroblast of cardiac tissue Keratocyte

Abdominal aorta Adipose tissue Anterior part of tongue Anterior segment of eyeball Aorta Ascending colon Bladder organ Bone marrow Brown adipose tissue Buccal mucosa Cardiac atrium Cardiac ventricle Chorioretinal region Conjunctiva Cornea Coronary artery Crista ampullaris Duodenum Endocrine pancreas Endometrium Exocrine pancreas Eye Eyelid Heart Heart right ventricle Ileum Inferior vena cava Inguinal lymph node Jejunum Lacrimal gland Large intestine Left coronary artery Left ovary Liver Lung Lymph node Mammary gland Mesenteric lymph node Mucosa of stomach Muscle of abdomen Muscle of pelvic diaphragm Muscularis mucosae of stomach Myometrium Ocular surface region Ovary Parotid gland Posterior part of tongue Posterior segment of eyeball Prostate gland Retinal neural layer Right cardiac atrium Right ovary Sclera Sigmoid colon Skin of abdomen Skin of body Skin of chest Small intestine Spleen Stomach Stomach smooth muscle Subcutaneous adipose tissue Sublingual gland Submandibular gland Testis Thoracic aorta Thymus Tongue Trachea Uterus Utricle of membranous labyrinth Vasculature

69-year-old stage 37-year-old stage 26-year-old stage 61-year-old stage 38-year-old stage 56-year-old stage 55-year-old stage 57-year-old stage 74-year-old stage 59-year-old stage 67-year-old stage 33-year-old stage 45-year-old stage 46-year-old stage 60-year-old stage 36-year-old stage 40-year-old stage

Normal

Female Male

10x 5' v2 Smart-seq3 Smart-seq2 10x 3' v3

Cell

Homo sapiens

Medial ganglionic eminence derived gabaergic interneuron L2/3 intratelencephalic projecting glutamatergic neuron Glutamatergic neuron Oligodendrocyte precursor cell L5 intratelencephalic projecting glutamatergic neuron Oligodendrocyte Committed oligodendrocyte precursor L4 intratelencephalic projecting glutamatergic neuron Lamp5 gabaergic interneuron Cajal-retzius cell Brain vascular cell Microglial cell Vip gabaergic interneuron Forebrain radial glial cell Immature astrocyte L5 extratelencephalic projecting glutamatergic cortical neuron L6b glutamatergic cortical neuron Pvalb gabaergic interneuron Near-projecting glutamatergic cortical neuron L6 intratelencephalic projecting glutamatergic neuron Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Sncg gabaergic interneuron Astrocyte Sst gabaergic interneuron Gabaergic neuron Neural progenitor cell Corticothalamic-projecting glutamatergic cortical neuron

Brodmann (1909) area 10 Brodmann (1909) area 17 Brodmann (1909) area 9 Forebrain Neocortex Prefrontal cortex Telencephalon Visual cortex

13-year-old stage 21st week post-fertilization stage 13th week post-fertilization stage 3-month-old stage 14th week post-fertilization stage 9-month-old stage 26th week post-fertilization stage 12th week post-fertilization stage 16th week post-fertilization stage 9th week post-fertilization stage Carnegie stage 23 31st week post-fertilization stage 32nd week post-fertilization stage Carnegie stage 21 18th week post-fertilization stage 33rd week post-fertilization stage 5-month-old stage 7-month-old stage 34th week post-fertilization stage 11th week post-fertilization stage

Normal

Female Male

10x multiome

Nucleus

Homo sapiens

B cell

Ulcerative colitis

10x 5' v1

Homo sapiens

Intratelencephalic-projecting glutamatergic cortical neuron

Brodmann (1909) area 13 Brodmann (1909) area 14 Brodmann (1909) area 19 Brodmann (1909) area 23 Brodmann (1909) area 24 Brodmann (1909) area 25 Brodmann (1909) area 32 Brodmann (1909) area 38 Brodmann (1909) area 40 Brodmann (1909) area 43 Brodmann (1909) area 46 Accessory basal amygdaloid nucleus Agranular insular cortex Anterior cortical amygdaloid nucleus Anterior olfactory nucleus Basolateral amygdaloid nuclear complex Bed nucleus of stria terminalis Body of caudate nucleus Central amygdaloid nucleus Cerebrocerebellum Claustrum of brain Corticomedial nuclear complex Cuneus cortex Dentate gyrus of hippocampal formation Epithalamus Extrastriate cortex Globus pallidus Granular insular cortex Gray matter of midbrain Hippocampal field Hypothalamus Inferior frontal gyrus Inferior temporal gyrus Intralaminar nuclear group Lateral amygdaloid nucleus Lateral entorhinal cortex Lateral posterior nucleus of thalamus Mammillary body Medial dorsal nucleus of thalamus Medial entorhinal cortex Medial zone of hypothalamus Midbrain tectum Middle temporal gyrus Nucleus accumbens Perirhinal cortex Piriform cortex Pontine nuclear group Posterior parahippocampal gyrus Pretectal region Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Pulvinar nucleus Putamen Red nucleus Retrosplenial region Septal nuclear complex Subicular complex Substantia innominata Substantia nigra Subthalamic nucleus Superior parietal cortex Superior temporal gyrus Supraoptic nucleus Temporal fusiform gyrus Uncal ca1 Ventral anterior nucleus of thalamus

42-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Transit amplifying cell of small intestine Bladder urothelial cell Progenitor cell of mammary luminal epithelium Club cell Respiratory tract goblet cell Serous cell of epithelium of bronchus Hepatocyte Intestinal crypt stem cell of colon Luminal cell of prostate epithelium Enterocyte of epithelium proper of small intestine Multiciliated columnar cell of tracheobronchial tree Conjunctival epithelial cell Enterochromaffin-like cell Best4+ enterocyte Retinal pigment epithelial cell Interstitial cell of cajal Pulmonary ionocyte Corneal epithelial cell Myo-medullary thymic epithelial cell Pancreatic acinar cell Pancreatic pp cell Blood vessel smooth muscle cell Basal cell Luminal epithelial cell of mammary gland Taste receptor cell Ionocyte Epithelial cell Intestinal tuft cell Pancreatic a cell Enteroendocrine cell Lung multiciliated epithelial cell Vestibular dark cell Enterocyte of epithelium proper of jejunum Myoepithelial cell Ovarian surface epithelial cell Enterocyte of epithelium proper of duodenum Small intestine goblet cell Transit amplifying cell of colon Tuft cell of colon Pancreatic d cell Paneth cell of colon Peritubular myoid cell Neuro-medullary thymic epithelial cell Pulmonary alveolar type 1 cell Paneth cell of epithelium of small intestine Duct epithelial cell Enteroendocrine cell of small intestine Enterocyte of epithelium proper of ileum Acinar cell of salivary gland Type b pancreatic cell Kidney epithelial cell Glandular secretory epithelial cell Acinar cell Medullary thymic epithelial cell Epithelial cell of uterus Mesothelial cell Tracheal goblet cell Supporting cell of vestibular epithelium Ciliated epithelial cell Serous cell of epithelium of trachea Intestinal crypt stem cell of small intestine Mucus secreting cell Pancreatic ductal cell Large intestine goblet cell Enterocyte of epithelium of large intestine Stratified squamous epithelial cell Epithelial fate stem cell Type l enteroendocrine cell Basal cell of prostate epithelium Sebocyte Intrahepatic cholangiocyte Keratocyte Pulmonary alveolar type 2 cell Salivary gland cell

Anterior part of tongue Anterior segment of eyeball Ascending colon Bladder organ Buccal mucosa Cardiac atrium Cardiac ventricle Chorioretinal region Conjunctiva Cornea Cortex of kidney Crista ampullaris Duodenum Endocrine pancreas Endometrium Exocrine pancreas Eye Eyelid Heart Heart right ventricle Ileum Jejunum Kidney Lacrimal gland Large intestine Left ovary Liver Lung Mammary gland Mucosa of stomach Muscle of abdomen Muscle of pelvic diaphragm Myometrium Ocular surface region Ovary Parotid gland Posterior part of tongue Posterior segment of eyeball Prostate gland Right ovary Sclera Sigmoid colon Skin of abdomen Skin of body Skin of chest Small intestine Stomach Stomach smooth muscle Sublingual gland Submandibular gland Testis Thymus Tongue Trachea Uterus Utricle of membranous labyrinth

69-year-old stage 37-year-old stage 26-year-old stage 61-year-old stage 38-year-old stage 56-year-old stage 55-year-old stage 57-year-old stage 74-year-old stage 59-year-old stage 67-year-old stage 33-year-old stage 45-year-old stage 46-year-old stage 60-year-old stage 36-year-old stage 40-year-old stage

Normal

Female Male

10x 5' v2 Smart-seq2 10x 3' v3

Cell

Homo sapiens

Cycling t cell Blood vessel endothelial cell Natural killer cell Endothelial cell of lymphatic vessel Mast cell Cd8-positive, alpha-beta t cell Plasmacytoid dendritic cell, human Macrophage Cd4-positive, cd25-positive, alpha-beta regulatory t cell Myeloid cell Plasma cell Salivary gland glandular cell Squamous epithelial cell T follicular helper cell B cell Pericyte Naive thymus-derived cd4-positive, alpha-beta t cell Monocyte Conventional dendritic cell Fibroblast

Alveolar ridge of mandible Buccal mucosa Gingiva of lower jaw Hypopharynx Larynx Mandible Mouth floor Oral cavity Oropharynx Tongue

66-year-old stage 69-year-old stage 75-year-old stage 65-year-old stage 43-year-old stage 53-year-old stage 61-year-old stage 54-year-old stage 48-year-old stage 56-year-old stage 55-year-old stage 50-year-old stage 80-year-old stage 51-year-old stage 57-year-old stage 72-year-old stage 74-year-old stage 35-year-old stage 58-year-old stage 67-year-old stage 32-year-old stage 77-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 70-year-old stage 60-year-old stage 18-year-old stage 73-year-old stage

Head and neck squamous cell carcinoma

Female Male

10x 5' transcription profiling 10x 3' v3 10x 3' v2

Cell

Homo sapiens

Caudal ganglionic eminence derived interneuron

Brodmann (1909) area 13 Brodmann (1909) area 14 Brodmann (1909) area 19 Brodmann (1909) area 23 Brodmann (1909) area 24 Brodmann (1909) area 25 Brodmann (1909) area 32 Brodmann (1909) area 38 Brodmann (1909) area 40 Brodmann (1909) area 43 Brodmann (1909) area 46 Accessory basal amygdaloid nucleus Agranular insular cortex Anterior cortical amygdaloid nucleus Anterior nuclear group Anterior olfactory nucleus Basolateral amygdaloid nuclear complex Bed nucleus of stria terminalis Body of caudate nucleus Central amygdaloid nucleus Centromedian nucleus of thalamus Claustrum of brain Corticomedial nuclear complex Cuneus cortex Dentate gyrus of hippocampal formation Dorsal tegmental nucleus Epithalamus Extrastriate cortex Globus pallidus Granular insular cortex Gray matter of midbrain Hippocampal field Hypothalamus Inferior frontal gyrus Inferior olivary complex Inferior temporal gyrus Intralaminar nuclear group Lateral amygdaloid nucleus Lateral entorhinal cortex Lateral geniculate body Lateral nuclear group of thalamus Lateral posterior nucleus of thalamus Mammillary body Medial dorsal nucleus of thalamus Medial entorhinal cortex Medial geniculate body Medial zone of hypothalamus Median tuberal portion Midbrain nucleus Midbrain tectum Middle temporal gyrus Nucleus accumbens Nucleus of dorsal thalamus Nucleus of medulla oblongata Parabrachial nucleus Perirhinal cortex Piriform cortex Pontine nuclear group Pontine reticular formation Pontine tegmentum Posterior parahippocampal gyrus Preoptic area Pretectal region Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Pulvinar nucleus Putamen Red nucleus Retrosplenial region Rostral ca3 Septal nuclear complex Spinal cord Subicular complex Substantia innominata Substantia nigra Subthalamic nucleus Superior parietal cortex Superior temporal gyrus Supraoptic nucleus Temporal fusiform gyrus Uncal ca1 Ventral anterior nucleus of thalamus

42-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Diffuse bipolar 1 cell Diffuse bipolar 4 cell Gabaergic amacrine cell Diffuse bipolar 2 cell Retinal ganglion cell Off parasol ganglion cell Offx cell On-bipolar cell Rod bipolar cell S cone cell On parasol ganglion cell Invaginating midget bipolar cell Retinal bipolar neuron H2 horizontal cell Retinal cone cell Glycinergic amacrine cell Retinal rod cell Flat midget bipolar cell Retina horizontal cell Amacrine cell Diffuse bipolar 3a cell Retinal progenitor cell Starburst amacrine cell Midget ganglion cell of retina Diffuse bipolar 6 cell Mueller cell H1 horizontal cell Diffuse bipolar 3b cell

Macula lutea Peripheral region of retina Retina

21st week post-fertilization stage 13th week post-fertilization stage 14th week post-fertilization stage 15th week post-fertilization stage 20th week post-fertilization stage 17th week post-fertilization stage 12th week post-fertilization stage 9th week post-fertilization stage 24th week post-fertilization stage 11th week post-fertilization stage

Normal

10x multiome

Nucleus

Homo sapiens

Classical monocyte Plasmacytoid dendritic cell Macrophage Conventional dendritic cell Non-classical monocyte

Blood Bone marrow Epithelial lining fluid Inguinal lymph node Jejunal epithelium Jejunum lamina propria Lung Mesenteric lymph node Spleen Thoracic lymph node

75-year-old stage Sixth decade stage 68-year-old stage 48-year-old stage 56-year-old stage Fifth decade stage Third decade stage 23-year-old stage 25-year-old stage 67-year-old stage 33-year-old stage 64-year-old stage Fourth decade stage 20-year-old stage Eighth decade stage 73-year-old stage 27-year-old stage

Normal

Female Male

10x 5' v2 10x 3' v3

Cell

Homo sapiens

T cell Podocyte Natural killer cell Parietal epithelial cell Kidney interstitial alternatively activated macrophage Cytotoxic t cell Endothelial cell Kidney loop of henle thin descending limb epithelial cell Mature nk t cell Mast cell Kidney collecting duct intercalated cell Epithelial cell of proximal tubule Plasmacytoid dendritic cell, human Kidney distal convoluted tubule epithelial cell Kidney collecting duct principal cell Kidney connecting tubule epithelial cell Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial cell Plasma cell B cell Monocyte Kidney loop of henle thin ascending limb epithelial cell Conventional dendritic cell Non-classical monocyte Mononuclear phagocyte

Kidney

66-year-old stage 42-year-old stage Sixth decade stage 53-year-old stage 52-year-old stage 48-year-old stage 30-year-old stage 39-year-old stage 56-year-old stage Fifth decade stage 57-year-old stage Third decade stage 49-year-old stage 35-year-old stage Seventh decade stage 41-year-old stage 31-year-old stage Fourth decade stage Eighth decade stage 47-year-old stage Ninth decade stage 40-year-old stage

Chronic kidney disease Normal Acute kidney failure

Female Male

10x 3' v3

Cell