Homo sapiens

Neuron

Inferior frontal gyrus Middle temporal gyrus Putamen Brodmann (1909) area 24 Posterior parahippocampal gyrus Anterior olfactory nucleus Brodmann (1909) area 38 Pretectal region Subicular complex Gray matter of midbrain Brodmann (1909) area 14 Brodmann (1909) area 19 Inferior temporal gyrus Hypothalamus Brodmann (1909) area 32 Cerebrocerebellum Dentate gyrus of hippocampal formation Bed nucleus of stria terminalis Brodmann (1909) area 13 Primary somatosensory cortex Substantia innominata Perirhinal cortex Body of caudate nucleus Extrastriate cortex Brodmann (1909) area 23 Epithalamus Substantia nigra Central amygdaloid nucleus Granular insular cortex Agranular insular cortex Globus pallidus Basolateral amygdaloid nuclear complex Ventral anterior nucleus of thalamus Anterior cortical amygdaloid nucleus Brodmann (1909) area 43 Primary auditory cortex Medial entorhinal cortex Red nucleus Corticomedial nuclear complex Lateral posterior nucleus of thalamus Brodmann (1909) area 46 Supraoptic nucleus Uncal ca1 Temporal fusiform gyrus Lateral entorhinal cortex Brodmann (1909) area 25 Primary motor cortex Pulvinar nucleus Primary visual cortex Subthalamic nucleus Superior parietal cortex Hippocampal field Piriform cortex Lateral amygdaloid nucleus Brodmann (1909) area 40 Claustrum of brain Midbrain tectum Mammillary body Pontine nuclear group Medial dorsal nucleus of thalamus Retrosplenial region Nucleus accumbens Medial zone of hypothalamus Intralaminar nuclear group Accessory basal amygdaloid nucleus Superior temporal gyrus Septal nuclear complex Cuneus cortex

50-year-old stage 60-year-old stage 42-year-old stage 29-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Taste receptor cell Myoepithelial cell Transit amplifying cell of small intestine Acinar cell Best4+ enterocyte Luminal cell of prostate epithelium Paneth cell of colon Pancreatic ductal cell Pulmonary alveolar type 1 cell Enterochromaffin-like cell Ciliated epithelial cell Progenitor cell of mammary luminal epithelium Corneal epithelial cell Small intestine goblet cell Pulmonary alveolar type 2 cell Club cell Enterocyte of epithelium proper of jejunum Ionocyte Pancreatic acinar cell Mesothelial cell Enterocyte of epithelium proper of duodenum Medullary thymic epithelial cell Neuro-medullary thymic epithelial cell Epithelial fate stem cell Basal cell of prostate epithelium Enterocyte of epithelium of large intestine Glandular secretory epithelial cell Interstitial cell of cajal Enteroendocrine cell of small intestine Basal cell Stratified squamous epithelial cell Tracheal goblet cell Epithelial cell Type b pancreatic cell Multiciliated columnar cell of tracheobronchial tree Duct epithelial cell Enterocyte of epithelium proper of small intestine Pancreatic d cell Myo-medullary thymic epithelial cell Epithelial cell of uterus Acinar cell of salivary gland Enteroendocrine cell Salivary gland cell Blood vessel smooth muscle cell Luminal epithelial cell of mammary gland Respiratory tract goblet cell Type l enteroendocrine cell Keratocyte Lung multiciliated epithelial cell Tuft cell of colon Intrahepatic cholangiocyte Serous cell of epithelium of trachea Bladder urothelial cell Transit amplifying cell of colon Hepatocyte Intestinal tuft cell Vestibular dark cell Enterocyte of epithelium proper of ileum Ovarian surface epithelial cell Pancreatic pp cell Sebocyte Paneth cell of epithelium of small intestine Pancreatic a cell Kidney epithelial cell Intestinal crypt stem cell of small intestine Intestinal crypt stem cell of colon Mucus secreting cell Retinal pigment epithelial cell Peritubular myoid cell Conjunctival epithelial cell Pulmonary ionocyte Large intestine goblet cell Supporting cell of vestibular epithelium Serous cell of epithelium of bronchus

Posterior part of tongue Posterior segment of eyeball Submandibular gland Stomach smooth muscle Anterior segment of eyeball Ileum Uterus Thymus Cortex of kidney Liver Skin of abdomen Parotid gland Testis Right ovary Bladder organ Sublingual gland Lung Small intestine Ovary Muscle of abdomen Trachea Mammary gland Kidney Muscle of pelvic diaphragm Mucosa of stomach Endometrium Sclera Utricle of membranous labyrinth Jejunum Cardiac ventricle Tongue Crista ampullaris Prostate gland Cardiac atrium Skin of chest Conjunctiva Eyelid Eye Chorioretinal region Sigmoid colon Cornea Duodenum Lacrimal gland Myometrium Endocrine pancreas Left ovary Ascending colon Stomach Exocrine pancreas Heart right ventricle Skin of body Buccal mucosa Ocular surface region Anterior part of tongue Heart Large intestine

57-year-old stage 46-year-old stage 60-year-old stage 45-year-old stage 74-year-old stage 33-year-old stage 67-year-old stage 40-year-old stage 37-year-old stage 36-year-old stage 59-year-old stage 56-year-old stage 61-year-old stage 26-year-old stage 69-year-old stage 38-year-old stage 55-year-old stage

Normal

Female Male

Smart-seq2 10x 5' v2 10x 3' v3

Cell

Homo sapiens

Endothelial cell of lymphatic vessel Macrophage Naive thymus-derived cd4-positive, alpha-beta t cell Mast cell Monocyte Conventional dendritic cell Fibroblast Blood vessel endothelial cell Salivary gland glandular cell Pericyte B cell Cd8-positive, alpha-beta t cell Cycling t cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell Plasmacytoid dendritic cell, human Squamous epithelial cell Plasma cell T follicular helper cell Natural killer cell Myeloid cell

Oropharynx Mouth floor Gingiva of lower jaw Mandible Tongue Hypopharynx Larynx Oral cavity Alveolar ridge of mandible Buccal mucosa

80-year-old stage 66-year-old stage 70-year-old stage 18-year-old stage 77-year-old stage 32-year-old stage 50-year-old stage 57-year-old stage 62-year-old stage 60-year-old stage 48-year-old stage 64-year-old stage 45-year-old stage 74-year-old stage 65-year-old stage 67-year-old stage 75-year-old stage 54-year-old stage 56-year-old stage 58-year-old stage 61-year-old stage 51-year-old stage 35-year-old stage 53-year-old stage 72-year-old stage 73-year-old stage 69-year-old stage 43-year-old stage 55-year-old stage

Head and neck squamous cell carcinoma

Female Male

10x 3' v3 10x 5' transcription profiling 10x 3' v2

Cell

Homo sapiens

Neuron

Inferior frontal gyrus Middle temporal gyrus Putamen Brodmann (1909) area 24 Posterior parahippocampal gyrus Anterior olfactory nucleus Brodmann (1909) area 38 Pretectal region Subicular complex Gray matter of midbrain Brodmann (1909) area 14 Brodmann (1909) area 19 Inferior temporal gyrus Hypothalamus Brodmann (1909) area 32 Dentate gyrus of hippocampal formation Lateral geniculate body Bed nucleus of stria terminalis Median tuberal portion Brodmann (1909) area 13 Primary somatosensory cortex Medial geniculate body Preoptic area Substantia innominata Perirhinal cortex Body of caudate nucleus Extrastriate cortex Lateral nuclear group of thalamus Dorsal tegmental nucleus Brodmann (1909) area 23 Centromedian nucleus of thalamus Epithalamus Substantia nigra Central amygdaloid nucleus Rostral ca3 Granular insular cortex Agranular insular cortex Globus pallidus Basolateral amygdaloid nuclear complex Parabrachial nucleus Ventral anterior nucleus of thalamus Nucleus of dorsal thalamus Anterior cortical amygdaloid nucleus Anterior nuclear group Brodmann (1909) area 43 Primary auditory cortex Medial entorhinal cortex Red nucleus Corticomedial nuclear complex Lateral posterior nucleus of thalamus Brodmann (1909) area 46 Nucleus of medulla oblongata Supraoptic nucleus Uncal ca1 Temporal fusiform gyrus Lateral entorhinal cortex Brodmann (1909) area 25 Midbrain nucleus Primary motor cortex Pulvinar nucleus Pontine tegmentum Primary visual cortex Subthalamic nucleus Spinal cord Superior parietal cortex Hippocampal field Inferior olivary complex Piriform cortex Lateral amygdaloid nucleus Brodmann (1909) area 40 Claustrum of brain Midbrain tectum Mammillary body Pontine reticular formation Pontine nuclear group Medial dorsal nucleus of thalamus Retrosplenial region Nucleus accumbens Medial zone of hypothalamus Intralaminar nuclear group Accessory basal amygdaloid nucleus Superior temporal gyrus Septal nuclear complex Cuneus cortex

50-year-old stage 60-year-old stage 42-year-old stage 29-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Gabaergic amacrine cell Retinal rod cell Diffuse bipolar 4 cell Flat midget bipolar cell H2 horizontal cell Offx cell Retinal cone cell Diffuse bipolar 2 cell Off parasol ganglion cell Diffuse bipolar 3a cell Diffuse bipolar 3b cell On-bipolar cell Invaginating midget bipolar cell H1 horizontal cell Starburst amacrine cell Diffuse bipolar 6 cell Retinal progenitor cell Diffuse bipolar 1 cell Mueller cell Retinal bipolar neuron On parasol ganglion cell Amacrine cell Glycinergic amacrine cell Retinal ganglion cell Retina horizontal cell Rod bipolar cell S cone cell Midget ganglion cell of retina

Macula lutea Peripheral region of retina Retina

9th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 11th week post-fertilization stage 21st week post-fertilization stage 20th week post-fertilization stage 17th week post-fertilization stage 15th week post-fertilization stage 14th week post-fertilization stage 24th week post-fertilization stage

Normal

10x multiome

Nucleus

Homo sapiens

Classical monocyte Non-classical monocyte Macrophage Conventional dendritic cell Plasmacytoid dendritic cell

Blood Mesenteric lymph node Spleen Epithelial lining fluid Lung Jejunum lamina propria Inguinal lymph node Bone marrow Jejunal epithelium Thoracic lymph node

Fourth decade stage 48-year-old stage 64-year-old stage 25-year-old stage 33-year-old stage 67-year-old stage Eighth decade stage 75-year-old stage 27-year-old stage 23-year-old stage Fifth decade stage 20-year-old stage 56-year-old stage 68-year-old stage 73-year-old stage Third decade stage Sixth decade stage

Normal

Female Male

10x 5' v2 10x 3' v3

Cell

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial cell Kidney connecting tubule epithelial cell Parietal epithelial cell Cytotoxic t cell Non-classical monocyte Kidney distal convoluted tubule epithelial cell Kidney collecting duct principal cell Mast cell Kidney loop of henle thin descending limb epithelial cell Kidney interstitial alternatively activated macrophage Monocyte Epithelial cell of proximal tubule Kidney collecting duct intercalated cell Conventional dendritic cell Podocyte Endothelial cell B cell Plasmacytoid dendritic cell, human Plasma cell Mature nk t cell T cell Natural killer cell Mononuclear phagocyte Kidney loop of henle thin ascending limb epithelial cell

Kidney

66-year-old stage Fourth decade stage 57-year-old stage 52-year-old stage 48-year-old stage 40-year-old stage Eighth decade stage Ninth decade stage Fifth decade stage 47-year-old stage 31-year-old stage 56-year-old stage 49-year-old stage 42-year-old stage 35-year-old stage 53-year-old stage 30-year-old stage Seventh decade stage 39-year-old stage Third decade stage 41-year-old stage Sixth decade stage

Normal Chronic kidney disease Acute kidney failure

Female Male

10x 3' v3

Cell

Homo sapiens

Neuron

Inferior frontal gyrus Middle temporal gyrus Putamen Brodmann (1909) area 24 Posterior parahippocampal gyrus Anterior olfactory nucleus Brodmann (1909) area 38 Pretectal region Subicular complex Gray matter of midbrain Brodmann (1909) area 14 Brodmann (1909) area 19 Inferior temporal gyrus Hypothalamus Brodmann (1909) area 32 Dentate gyrus of hippocampal formation Lateral geniculate body Bed nucleus of stria terminalis Median tuberal portion Brodmann (1909) area 13 Primary somatosensory cortex Medial geniculate body Preoptic area Substantia innominata Perirhinal cortex Body of caudate nucleus Extrastriate cortex Lateral nuclear group of thalamus Brodmann (1909) area 23 Centromedian nucleus of thalamus Epithalamus Substantia nigra Central amygdaloid nucleus Rostral ca3 Granular insular cortex Agranular insular cortex Globus pallidus Basolateral amygdaloid nuclear complex Parabrachial nucleus Ventral anterior nucleus of thalamus Nucleus of dorsal thalamus Anterior cortical amygdaloid nucleus Anterior nuclear group Brodmann (1909) area 43 Primary auditory cortex Medial entorhinal cortex Red nucleus Corticomedial nuclear complex Lateral posterior nucleus of thalamus Brodmann (1909) area 46 Nucleus of medulla oblongata Supraoptic nucleus Uncal ca1 Cerebellar nuclear complex Temporal fusiform gyrus Lateral entorhinal cortex Brodmann (1909) area 25 Primary motor cortex Pulvinar nucleus Primary visual cortex Subthalamic nucleus Superior parietal cortex Hippocampal field Inferior olivary complex Piriform cortex Lateral amygdaloid nucleus Brodmann (1909) area 40 Claustrum of brain Midbrain tectum Mammillary body Pontine nuclear group Medial dorsal nucleus of thalamus Retrosplenial region Nucleus accumbens Medial zone of hypothalamus Intralaminar nuclear group Accessory basal amygdaloid nucleus Superior temporal gyrus Septal nuclear complex Cuneus cortex

50-year-old stage 60-year-old stage 42-year-old stage 29-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Best4+ enterocyte Transit amplifying cell Intestinal crypt stem cell Paneth cell Enteroendocrine cell Tuft cell of small intestine Mucous neck cell of gastric gland Enterocyte Foveolar cell of stomach M cell of gut Intestine goblet cell

Duodenal epithelium Ileum Ileum lamina propria Mesenteric lymph node Small intestine Jejunum Epithelium of small intestine Lamina propria of small intestine Duodenum Ileal epithelium

18-year-old stage Fourth decade stage 50-year-old stage Prime adult stage 52-year-old stage 60-year-old stage 22-year-old stage 45-year-old stage 25-year-old stage 67-year-old stage Eighth decade stage 37-year-old stage 14-year-old stage 6-year-old stage 36-year-old stage Fifth decade stage 20-year-old stage 31-year-old stage 56-year-old stage 10-year-old stage 13-year-old stage Seventh decade stage 12-year-old stage 4-year-old stage 9-year-old stage Third decade stage 29-year-old stage 87-year-old stage Sixth decade stage 11-year-old stage

Normal Crohn disease Celiac disease

Female Male

10x 5' v2 10x 5' v1 10x 3' v3 10x 5' transcription profiling 10x 3' v1 10x 3' v2

Cell

Homo sapiens

Schwann cell Cardiac muscle cell Lymphocyte Macrophage Mesothelial cell Endocardial cell Adipocyte Cardiac blood vessel endothelial cell Fibroblast Pericyte Smooth muscle cell Neuron

Right atrium auricular region

Eighth decade stage Ninth decade stage Fifth decade stage Seventh decade stage Sixth decade stage

Normal Heart failure Myocardial ischemia Heart valve disorder

Female Male

10x 3' v3

Nucleus

Homo sapiens

Pulmonary alveolar type 1 cell Pulmonary alveolar type 2 cell Club cell Basal cell Stem cell Neuroendocrine cell Lung secretory cell Ciliated cell Goblet cell

Lung Bronchus Alveolar sac Lung epithelium Nasopharynx

Normal

10x 5' v1 10x 3' v3 10x 3' v2

Cell

Homo sapiens

T cell

Abdominal wall Liver Adnexa of uterus Right ovary Caecum Fallopian tube Transverse colon Urinary bladder Omentum Diaphragm Parietal peritoneum Peritoneum Paracolic gutter Ascitic fluid Abdomen Intestine Left ovary Large intestine Lymph node

66-year-old stage 70-year-old stage 77-year-old stage 50-year-old stage 57-year-old stage 76-year-old stage 46-year-old stage 60-year-old stage 80 year-old and over stage 64-year-old stage 45-year-old stage 75-year-old stage 71-year-old stage 78-year-old stage 63-year-old stage 59-year-old stage 47-year-old stage 56-year-old stage 58-year-old stage 68-year-old stage 61-year-old stage 69-year-old stage 41-year-old stage 55-year-old stage

Malignant ovarian serous tumor

Female

10x 3' v3

Cell