Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Cerebellar inhibitory gabaergic interneuron Microglial cell Bergmann glial cell Pericyte Cerebral cortex neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Fibroblast

Red nucleus

29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Lamp5 gabaergic interneuron

Neocortex

Adult stage

Normal

Female Male

10x 3' v3

Cell

Mus musculus

Cardiac valve cell Spinal cord interneuron Premigratory neural crest cell Paraxial cell Notochordal cell Neuroplacodal cell Neurectodermal cell Hemangioblast Mesodermal cell Gut endothelial cell Primitive red blood cell Splanchnic mesodermal cell Surface ectodermal cell Midbrain dopaminergic neuron Endodermal cell Anterior visceral endoderm cell

Embryo

Theiler stage 14

Normal

Slide-seqv2

Drosophila melanogaster

Adult enteroendocrine precursor cell Adult anterior midgut class i enteroendocrine cell Adult anterior midgut class ii enteroendocrine cell Adult class iii enteroendocrine cell Adult class i enteroendocrine cell Adult middle midgut class ii enteroendocrine cell Adult posterior midgut class ii enteroendocrine cell Adult posterior midgut class i enteroendocrine cell Adult middle midgut class i enteroendocrine cell

Adult midgut

Mature adult stage

Normal

Female

10x genomics v2

Homo sapiens

Neutrophil Erythrocyte Mature nk t cell Mast cell Platelet Ionocyte Epithelial cell Myeloid cell B cell

Respiratory airway

74-year-old stage

Covid-19

Female

10x 3' v3

Cell

Mus musculus

Cardiac valve cell Spinal cord interneuron Premigratory neural crest cell Paraxial cell Notochordal cell Neuroplacodal cell Neurectodermal cell Hemangioblast Mesodermal cell Gut endothelial cell Primitive red blood cell Splanchnic mesodermal cell Surface ectodermal cell Midbrain dopaminergic neuron Endodermal cell Anterior visceral endoderm cell

Embryo

Theiler stage 14

Normal

Slide-seqv2

Homo sapiens

Leukocyte Epithelial cell of nephron Mesenchymal stem cell

Kidney

Pediatric stage

Wilms tumor

10x 3' v3

Cell

Mus musculus

Cardiac valve cell Spinal cord interneuron Premigratory neural crest cell Paraxial cell Notochordal cell Neuroplacodal cell Neurectodermal cell Hemangioblast Mesodermal cell Gut endothelial cell Primitive red blood cell Splanchnic mesodermal cell Surface ectodermal cell Midbrain dopaminergic neuron Endodermal cell Anterior visceral endoderm cell

Embryo

Theiler stage 14

Normal

Slide-seqv2

Homo sapiens

Podocyte Renal principal cell Renal beta-intercalated cell Glomerular endothelial cell Kidney interstitial fibroblast Capillary endothelial cell Epithelial cell of proximal tubule Renal intercalated cell Vasa recta descending limb cell Renal alpha-intercalated cell Kidney connecting tubule epithelial cell Urothelial cell Kidney loop of henle thick ascending limb epithelial cell Vasa recta ascending limb cell Kidney epithelial cell Progenitor cell Myofibroblast cell

Renal medulla Renal pelvis Kidney blood vessel Kidney Cortex of kidney

53-year-old stage 2-year-old stage 44-year-old stage 12-year-old stage 72-year-old stage 49-year-old stage 67-year-old stage 64-year-old stage 19-month-old stage 70-year-old stage 63-year-old stage 4-year-old stage

Normal

Female Male

10x 3' v2

Cell

Mus musculus

Cardiac valve cell Spinal cord interneuron Premigratory neural crest cell Paraxial cell Notochordal cell Neuroplacodal cell Neurectodermal cell Hemangioblast Mesodermal cell Gut endothelial cell Primitive red blood cell Splanchnic mesodermal cell Surface ectodermal cell Midbrain dopaminergic neuron Endodermal cell Anterior visceral endoderm cell

Embryo

Theiler stage 14

Normal

Slide-seqv2

Homo sapiens

Neutrophil Mature nk t cell Platelet Myeloid cell Plasma cell B cell Dendritic cell

Blood

49-year-old stage

Covid-19

Male

10x 3' v3

Cell

Homo sapiens

Neutrophil Erythrocyte Mature nk t cell Mast cell Epithelial cell Myeloid cell B cell

Respiratory airway

66-year-old stage

Covid-19

Female

10x 3' v3

Cell