Homo sapiens

Cd14-positive, cd16-negative classical monocyte Intermediate monocyte Cd14-low, cd16-positive monocyte

Blood

32-year-old stage 57-year-old stage 62-year-old stage 60-year-old stage 64-year-old stage 25-year-old stage 33-year-old stage 65-year-old stage 27-year-old stage 28-year-old stage 36-year-old stage 63-year-old stage 59-year-old stage 31-year-old stage 56-year-old stage 58-year-old stage 61-year-old stage 34-year-old stage 35-year-old stage 30-year-old stage 26-year-old stage 12-year-old stage 29-year-old stage 55-year-old stage 11-year-old stage

Normal Cytomegalovirus infection

Female Male

10x 3' v3

Cell

Homo sapiens

Trophoblast giant cell Endothelial cell of lymphatic vessel Macrophage Endothelial cell of uterus Extravillous trophoblast Syncytiotrophoblast cell Stromal cell Epithelial cell Endothelial cell of placenta Placental villous trophoblast Granulocyte Group 3 innate lymphoid cell, human B cell Dendritic cell Plasma cell Regulatory t cell T cell Hofbauer cell Decidual natural killer cell, human Embryonic fibroblast Natural killer cell Uterine smooth muscle cell

Blood Decidua Decidua basalis Placenta

9th week post-fertilization stage Carnegie stage 14 12th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 22 11th week post-fertilization stage Carnegie stage 23 Carnegie stage 18 Carnegie stage 16

Normal

Female

10x 3' v3 10x multiome 10x 3' v2

Cell Nucleus

Homo sapiens

Osteoblast Myofibroblast cell Eurydendroid cell Glial cell Mesothelial cell Stromal cell Interstitial cell of cajal Epithelial cell Cell of skeletal muscle Enteroendocrine cell Vascular associated smooth muscle cell Fibroblast Hepatocyte Endothelial cell Skeletal muscle satellite cell Epithelial cell of nephron Smooth muscle cell Neuron Keratinocyte Chondrocyte Melanocyte

Thymus Mesenteric lymph node Liver Spleen Kidney Bone marrow Gut wall Yolk sac Skin of body

9th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 22 11th week post-fertilization stage 17th week post-fertilization stage 15th week post-fertilization stage Carnegie stage 19 Carnegie stage 13 14th week post-fertilization stage 16th week post-fertilization stage Carnegie stage 23 Carnegie stage 20

Normal

Female Male

10x 5' v1 10x 3' v2

Cell

Homo sapiens

Myofibroblast cell Smooth muscle cell of the pulmonary artery Pulmonary alveolar type 1 cell Capillary endothelial cell Naive b cell Classical monocyte Endothelial cell of lymphatic vessel Alveolar capillary type 2 endothelial cell Pulmonary alveolar type 2 cell Muscle cell Club cell Non-classical monocyte Ionocyte Macrophage Mesothelial cell Alveolar macrophage Alveolar type 1 fibroblast cell Effector memory cd4-positive, alpha-beta t cell Mast cell Basal cell Cd16-negative, cd56-bright natural killer cell, human Lung multiciliated epithelial cell Plasmablast Vein endothelial cell Dendritic cell, human Conventional dendritic cell Fibroblast Central memory cd4-positive, alpha-beta t cell Effector memory cd8-positive, alpha-beta t cell Pericyte Plasma cell Erythrocyte Regulatory t cell T cell Memory b cell Plasmacytoid dendritic cell Effector memory cd8-positive, alpha-beta t cell, terminally differentiated Fibroblast of lung T follicular helper cell Natural killer cell Endothelial cell of artery Cd16-positive, cd56-dim natural killer cell, human Goblet cell

Lung Bronchus Upper lobe of left lung Lung parenchyma Lower lobe of left lung

66-year-old stage 21-year-old stage 32-year-old stage 50-year-old stage 62-year-old stage 46-year-old stage 22-year-old stage 64-year-old stage 25-year-old stage 65-year-old stage 67-year-old stage Eighth decade stage 75-year-old stage 23-year-old stage 37-year-old stage 59-year-old stage 54-year-old stage Fifth decade stage 20-year-old stage 31-year-old stage 56-year-old stage 58-year-old stage 61-year-old stage 51-year-old stage 49-year-old stage 35-year-old stage Seventh decade stage 29-year-old stage 41-year-old stage Sixth decade stage

Normal

Female Male

10x 5' transcription profiling 10x 3' v2

Cell

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Myofibroblast cell Kidney cortex collecting duct principal cell Schwann cell Juxtaglomerular complex cell Inflammatory macrophage Kidney inner medulla collecting duct epithelial cell Classical monocyte Kidney connecting tubule epithelial cell Parietal epithelial cell Papillary tips cell Kidney loop of henle short descending thin limb epithelial cell Macrophage Kidney distal convoluted tubule epithelial cell Kidney collecting duct alpha-intercalated cell Renal cortical fibroblast Kidney interstitial fibroblast Kidney collecting duct principal cell Kidney loop of henle thin descending limb epithelial cell Adventitial fibroblast Kidney efferent arteriole endothelial cell Adipocyte Endothelial cell of venule Macula densa epithelial cell Kidney loop of henle cortical thick ascending limb epithelial cell Vasa recta ascending limb cell Renal beta-intercalated cell Kidney resident macrophage Epithelial cell of proximal tubule Vein endothelial cell Vascular associated smooth muscle cell Epithelial cell of proximal tubule segment 2 Fibroblast Podocyte Epithelial cell of proximal tubule segment 1 Endothelial cell Glomerular capillary endothelial cell B cell Dendritic cell Plasma cell Peritubular capillary endothelial cell Mesangial cell Kidney cortex peritubular capillary cell T cell Vasa recta descending limb cell Kidney loop of henle medullary thick ascending limb epithelial cell Renal medullary fibroblast Natural killer cell Epithelial cell of proximal tubule segment 3 Kidney loop of henle thin ascending limb epithelial cell

Kidney

12-month-old stage 3-month-old stage 4-month-old stage 20-month-old stage 3-6 month-old mature stage 7-month-old stage 2-month-old stage

Normal Acute kidney failure

Female Male

10x multiome 10x 3' v2

Nucleus

Drosophila melanogaster

Adult malpighian tubule bar-shaped cell of initial segment Eo sensory organ accessory cell Multidendritic neuron Adult olfactory receptor neuron gr21a/63a Lamina monopolar neuron l4 Early elongation stage spermatid Transmedullary y neuron tmy5a Main body follicle cell Adult olfactory receptor neuron or67d Adult cholinergic neuron Medulla intrinsic neuron mi15 Mechanosensory neuron of leg chordotonal organ Spermatocyte cyst cell Medulla intrinsic neuron mi1 Gustatory receptor neuron Proximal medullary amacrine neuron pm4 Distal medullary amacrine neuron dm9 Midgut large flat cell Columnar neuron t1 Adult tracheocyte Transmedullary y neuron tmy4 Transmedullary neuron tm9 Cyst progenitor cell Muscle cell Tendon cell Adult olfactory receptor neuron ir75d Head cyst cell Leg muscle motor neuron Sensory neuron Enteroblast Distal medullary amacrine neuron dm10 Somatic muscle cell Auditory sensory neuron Proximal medullary amacrine neuron pm2 Ensheathing glial cell Adult astrocyte-like glial cell Escort cell Lobula columnar neuron lc17 Lobula columnar neuron lc12 Follicle cell of egg chamber Spermatocyte Antennal olfactory receptor neuron of coeloconic sensillum Enteroendocrine cell Adult olfactory receptor neuron or65 Kenyon cell Early-mid elongation-stage spermatid Epithelial cell Ocellar retinula cell Transmedullary neuron tm3 Adult glial cell Centrifugal neuron c3 Adult brain cell body glial cell Germline cell Leg taste bristle chemosensory neuron T2a neuron Adult optic chiasma glial cell Mechanosensory neuron Male accessory gland secondary cell Cns surface glial cell Visceral muscle cell T2 neuron Visual pigment cell (sensu nematoda and protostomia) Medulla intrinsic neuron mi9 Labral sense organ mechanosensory neuron Lamina wide-field 1 neuron Hemocyte (sensu arthropoda) Distal medullary amacrine neuron dm11 Transmedullary neuron tm20 Olfactory receptor neuron Transmedullary y neuron tmy8 Dopaminergic neuron Lamina monopolar neuron l3 Enterocyte of anterior adult midgut epithelium Adult malpighian tubule principal cell of initial segment Lamina monopolar neuron l1 Cyst cell of testis Chordotonal neuron Lamina monopolar neuron l2 Transmedullary neuron tm2 Dorsal appendage forming follicle cell Lamina monopolar neuron l5 Medulla intrinsic neuron mi4 Cardial cell Compound eye cone cell Adult malpighian tubule principal cell Nociceptive neuron Copper cell Eye photoreceptor cell Gustatory receptor neuron of the labellum Neuron of aristal sensillum Distal medullary amacrine neuron dm3 Adult brain perineurial glial cell Transmedullary neuron tm5c Outer photoreceptor cell Adult abdominal pericardial cell Perineurial glial cell Antennal olfactory receptor neuron of basiconic sensillum Optic-lobe-associated cortex glial cell Adult midgut enterocyte Adult neuron Adult olfactory receptor neuron or92a Crystal cell Gamma kenyon cell Indirect flight muscle cell Antennal lobe projection neuron Photoreceptor cell r7 Adult olfactory receptor neuron or47b Alpha'/beta' kenyon cell Distal medullary amacrine neuron dm8a Adult renal stem cell Ovarian sheath cell Stretch follicle cell Enterocyte of posterior adult midgut epithelium Centrifugal neuron c2 Intestinal stem cell Cell body glial cell Photoreceptor cell r8 Adult dopaminergic pam neuron Adult malpighian tubule stellate cell of main segment Adult enteroendocrine cell Lamina wide-field 2 neuron T3 neuron Adult olfactory receptor neuron or88a Transmedullary neuron tm1 Adult differentiating enterocyte Maxillary palp olfactory receptor neuron Subperineurial glial cell Spermatid Lobula columnar neuron lc10 Distal medullary amacrine neuron dm12 Transmedullary neuron tm4 Interfollicle cell Neuron Posterior terminal follicle cell Dorsal margin photoreceptor cell Tormogen cell Adult oenocyte Spermatogonium Polar follicle cell Adult malpighian tubule principal cell of lower ureter Fat body cell Adult malpighian tubule principal cell of lower segment Adult antennal olfactory receptor neuron Transmedullary neuron tm29 Male accessory gland main cell Johnston organ neuron Adult olfactory receptor neuron or13a Transmedullary y neuron tmy14 Adult enterocyte Mid-late elongation-stage spermatid

Post-embryonic organism Imaginal disc-derived wing Testis Malpighian tubule Antenna Ovary Haltere Insect leg Panarthropod head Male reproductive gland Insect proboscis Digestive tract Open tracheal system trachea Insect adult thorax Arthropod fat body Dorsal vessel heart Body wall

Day 1 of adulthood Day 3 of adulthood Day 5 of adulthood Day 2 of adulthood

Normal

Female Male Mixed sex

10x genomics v3

Mus musculus

Cerebral cortex endothelial cell Endothelial cell of hepatic sinusoid Endothelial cell of lymphatic vessel Endocardial cell Vein endothelial cell Brain pericyte Pericyte Endothelial cell Embryonic blood vessel endothelial progenitor cell Glomerular endothelial cell Endothelial cell of artery Microvascular endothelial cell

Embryo

Theiler stage 23 Theiler stage 24 Theiler stage 21 Theiler stage 13 Theiler stage 25 Theiler stage 17 Theiler stage 16 Theiler stage 26 Theiler stage 12 Theiler stage 18 Theiler stage 20 Theiler stage 19 Theiler stage 27 Theiler stage 14 Theiler stage 15 Theiler stage 22

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Cardiac muscle cell

Interventricular septum Apex of heart Heart left ventricle Heart right ventricle

Fourth decade stage Postnatal stage Eighth decade stage Fifth decade stage Pediatric stage Seventh decade stage Third decade stage Sixth decade stage

Normal Dilated cardiomyopathy Non-compaction cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy

Female Male

10x 3' v3 10x 3' v2

Nucleus

Mus musculus

Myofibroblast cell Muscle precursor cell Myoblast Myotube

Embryo

Theiler stage 23 Theiler stage 24 Theiler stage 21 Theiler stage 13 Theiler stage 25 Theiler stage 17 Theiler stage 16 Theiler stage 26 Theiler stage 12 Theiler stage 18 Theiler stage 20 Theiler stage 19 Theiler stage 27 Theiler stage 14 Theiler stage 15 Theiler stage 22

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney connecting tubule epithelial cell Parietal epithelial cell Papillary tips cell Non-classical monocyte Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Mast cell Kidney loop of henle thin descending limb epithelial cell Renal interstitial pericyte Neutrophil Kidney interstitial alternatively activated macrophage Epithelial cell of proximal tubule Kidney collecting duct intercalated cell Conventional dendritic cell Podocyte Endothelial cell B cell Plasmacytoid dendritic cell, human Plasma cell Mature nk t cell T cell Neural cell Mononuclear phagocyte Kidney loop of henle thin ascending limb epithelial cell

Renal medulla Cortex of kidney Kidney Renal papilla

66-year-old stage Fourth decade stage 57-year-old stage 76-year-old stage 45-year-old stage Eighth decade stage 14-year-old stage 63-year-old stage 59-year-old stage 54-year-old stage Fifth decade stage Seventh decade stage 69-year-old stage Third decade stage 29-year-old stage Sixth decade stage

Normal Chronic kidney disease Acute kidney failure

Female Male

10x 3' v3

Nucleus

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney connecting tubule epithelial cell Parietal epithelial cell Papillary tips cell Non-classical monocyte Lymphocyte Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Mast cell Kidney loop of henle thin descending limb epithelial cell Renal interstitial pericyte Neutrophil Kidney interstitial alternatively activated macrophage Epithelial cell of proximal tubule Kidney collecting duct intercalated cell Conventional dendritic cell Podocyte Endothelial cell B cell Plasmacytoid dendritic cell, human Plasma cell T cell Neural cell Mononuclear phagocyte Kidney loop of henle thin ascending limb epithelial cell

Renal medulla Cortex of kidney Kidney Renal papilla

66-year-old stage 70-year-old stage Fourth decade stage 57-year-old stage 76-year-old stage 52-year-old stage 48-year-old stage 64-year-old stage 45-year-old stage 40-year-old stage Eighth decade stage 14-year-old stage 36-year-old stage 63-year-old stage 59-year-old stage 54-year-old stage Fifth decade stage 47-year-old stage 31-year-old stage 56-year-old stage 49-year-old stage 42-year-old stage 35-year-old stage 53-year-old stage 30-year-old stage Seventh decade stage 39-year-old stage 69-year-old stage Third decade stage 43-year-old stage 29-year-old stage 41-year-old stage Sixth decade stage

Normal Chronic kidney disease Acute kidney failure

Female Male

10x 3' v3

Nucleus Cell

Mus musculus

Pancreatic endocrine cell Schwann cell Pancreatic ductal cell Pancreatic acinar cell Cell Type b pancreatic cell Pancreatic d cell Hematopoietic cell Endothelial cell Pancreatic stellate cell Pancreatic pp cell Pancreatic a cell

Islet of langerhans Pancreas

Theiler stage 23 Theiler stage 21 6-month-old stage 3-month-old stage 4-month-old stage 20-month-old stage and over 5-week-old stage Theiler stage 20 2-month-old stage 2-week-old stage Theiler stage 22 8-week-old stage

Normal Type 1 diabetes mellitus Endocrine pancreas disorder Type 2 diabetes mellitus

Female Male

10x 3' v3 10x 3' v2

Cell