Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial fibroblast Leukocyte Kidney collecting duct principal cell Macrophage Blood vessel smooth muscle cell Endothelial cell Kidney collecting duct intercalated cell Kidney distal convoluted tubule epithelial cell

Renal medulla

54-year-old stage

Normal

Male

Slide-seqv2

Homo sapiens

Corticothalamic-projecting glutamatergic cortical neuron

Middle temporal gyrus

43-year-old stage 68-year-old stage 88-year-old stage 86-year-old stage 82-year-old stage 83-year-old stage 60-year-old stage 75-year-old stage 80-year-old stage 77-year-old stage Adult stage 89-year-old stage 78-year-old stage 72-year-old stage 80 year-old and over stage 81-year-old stage 87-year-old stage 84-year-old stage 65-year-old stage 85-year-old stage 50-year-old stage 29-year-old stage 69-year-old stage 70-year-old stage

Dementia Normal

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

Pulmonary alveolar type 2 cell Epithelial cell of lower respiratory tract Ciliated cell Pericyte Endothelial cell of lymphatic vessel Smooth muscle cell Endothelial cell Pulmonary alveolar type 1 cell Fibroblast

Alveolus of lung

60-year-old stage 63-year-old stage 61-year-old stage 65-year-old stage 73-year-old stage

Pulmonary emphysema Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial fibroblast Leukocyte Kidney collecting duct principal cell Macrophage Blood vessel smooth muscle cell Endothelial cell Kidney collecting duct intercalated cell Kidney distal convoluted tubule epithelial cell

Renal medulla

64-year-old stage

Normal

Female

Slide-seqv2

Homo sapiens

Leukocyte Pericyte Smooth muscle cell Stromal cell Endothelial cell

Ovary

62-year-old stage 58-year-old stage 65-year-old stage

Normal

Female

10x scatac-seq

Nucleus

Mus musculus

Notochordal cell Spinal cord interneuron Paraxial cell Neurectodermal cell Gut endothelial cell Splanchnic mesodermal cell Hemangioblast Cardiac valve cell Endodermal cell Primitive red blood cell Midbrain dopaminergic neuron Premigratory neural crest cell Mesodermal cell Neuroplacodal cell Surface ectodermal cell

Embryo

Theiler stage 14

Normal

Slide-seqv2

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial fibroblast Leukocyte Kidney proximal convoluted tubule epithelial cell Podocyte Kidney collecting duct principal cell Macrophage Blood vessel smooth muscle cell Endothelial cell Kidney collecting duct intercalated cell Mesangial cell Kidney distal convoluted tubule epithelial cell

Kidney

6-month-old stage

Autosomal dominant polycystic kidney disease

Male

Slide-seqv2

Danio rerio

Photoreceptor cell

Multicellular anatomical structure

Segmentation:14-19 somites Hatching:pec-fin Larval:protruding-mouth Pharyngula:prim-5 Pharyngula:high-pec Hatching:long-pec Segmentation:20-25 somites Segmentation:26+ somites Pharyngula:prim-15 Pharyngula:prim-25

Normal

Sci-rna-seq3

Nucleus

Homo sapiens

Astrocyte Microglial cell Retinal pigment epithelial cell Mueller cell

Fovea centralis Macula lutea proper Peripheral region of retina

83-year-old stage 78-year-old stage 84-year-old stage 65-year-old stage 73-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Leukocyte Kidney cell Podocyte Glomerular mesangial cell Epithelial cell of proximal tubule Kidney interstitial cell Endothelial cell Kidney connecting tubule epithelial cell Kidney epithelial cell Mesonephric nephron tubule epithelial cell

Kidney

14th week post-fertilization stage 9th week post-fertilization stage 16th week post-fertilization stage 11th week post-fertilization stage Carnegie stage 19

Normal

Female Male

10x 3' v2

Cell

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial fibroblast Kidney inner medulla collecting duct epithelial cell Leukocyte Kidney proximal convoluted tubule epithelial cell Podocyte Parietal epithelial cell Pericyte Kidney collecting duct principal cell Blood vessel smooth muscle cell Kidney loop of henle thin descending limb epithelial cell Endothelial cell Kidney loop of henle epithelial cell Urothelial cell Kidney collecting duct intercalated cell Mesangial cell Kidney connecting tubule epithelial cell Kidney distal convoluted tubule epithelial cell

Renal medulla

64-year-old stage

Normal

Female

Slide-seqv2

Callithrix jacchus

Glutamatergic neuron

Hippocampal formation

Prime adult stage

Normal

Female Male

10x 3' v3

Nucleus