Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Autosomal dominant polycystic kidney disease

Male

Slide-seqv2

Homo sapiens

B-2 b cell Cd38-negative naive b cell Unswitched memory b cell Plasmablast

Blood

Sixth decade stage Fifth decade stage Seventh decade stage Fourth decade stage

Covid-19 Normal

Female Male

10x 5' v2 10x 5' v1

Cell

Homo sapiens

T cell Natural killer cell Mast cell Cd8-positive, alpha-beta t cell Plasmacytoid dendritic cell Cd14-positive, cd16-low monocyte Mature neutrophil Macrophage Cd4-positive, cd25-positive, alpha-beta regulatory t cell Memory b cell Cd16-positive, cd56-dim natural killer cell, human Plasma cell Cd4-positive, alpha-beta t cell Eosinophil Cd14-low, cd16-positive monocyte B cell Naive t cell Naive b cell Conventional dendritic cell Cd16-negative, cd56-bright natural killer cell, human Immature neutrophil

Intercostal muscle

Sixth decade stage Third decade stage Seventh decade stage Fourth decade stage Eighth decade stage Young adult stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Normal

Male

Slide-seqv2

Homo sapiens

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Cortex of kidney

62-year-old stage

Normal

Male

Slide-seqv2

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Dentate gyrus granule cell Hippocampal ca1-3 neuron Lamp5 lhx6 neuron Medial ganglionic eminence derived interneuron Microglial cell Thalamic excitatory neuron B cell Pericyte Cerebral cortex neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Fibroblast Mammillary body neuron

Subthalamic nucleus

42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Retinal ganglion cell Retinal bipolar neuron Microglial cell Retinal cone cell Retinal rod cell Retina horizontal cell Amacrine cell Macroglial cell Retinal blood vessel endothelial cell

Peripheral region of retina Macula lutea

71-year-old stage 68-year-old stage 86-year-old stage

Normal

Male

10x 3' v3

Cell

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Normal

Male

Slide-seqv2

Homo sapiens

Midbrain-derived inhibitory neuron T cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Amygdala excitatory neuron Committed oligodendrocyte precursor Cerebellar granule cell Lamp5 lhx6 neuron Eccentric medium spiny neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Cerebellar inhibitory gabaergic interneuron Ependymal cell Microglial cell Thalamic excitatory neuron Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast Medium spiny neuron Mammillary body neuron

Hypothalamus

42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Cd8-positive, alpha-beta t cell Cd4-positive helper t cell Epithelial cell Myeloid cell Malignant cell Fibroblast

Kidney

61-year-old stage

Renal cell carcinoma

Male

Slide-seqv2

Homo sapiens

Retinal ganglion cell Retinal bipolar neuron Microglial cell Retinal cone cell Retinal rod cell Obsolete somatic cell Amacrine cell Mueller cell

Retinal neural layer

42-year-old stage 53-year-old stage 80-year-old stage

Normal

Female Male

10x genomics v2

Homo sapiens

Igg plasmablast Memory b cell Plasmablast Iga plasmablast Transitional stage b cell Naive b cell

Blood

37-year-old stage 75-year-old stage Sixth decade stage 53-year-old stage 61-year-old stage 54-year-old stage 68-year-old stage 48-year-old stage 39-year-old stage 29-year-old stage 38-year-old stage Fifth decade stage 84-year-old stage 82-year-old stage Third decade stage 80 year-old and over stage 49-year-old stage Seventh decade stage 59-year-old stage Adult stage 67-year-old stage 62-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 78-year-old stage 36-year-old stage Fourth decade stage 63-year-old stage Eighth decade stage 47-year-old stage 73-year-old stage 27-year-old stage

Covid-19 Normal

Female Male

Seq-well 10x 3' v3 10x 3' v2

Cell