Mus musculus

Obsolete inhibitory neuron Oligodendrocyte precursor cell Oligodendrocyte Brain microvascular endothelial cell Obsolete excitatory neuron Astrocyte

Normal

10x 3' v2

Homo sapiens

Endothelial cell of lymphatic vessel Endothelial cell of artery Capillary endothelial cell Vein endothelial cell

Thymus

13th week post-fertilization stage 2-year-old stage 3-month-old stage 14th week post-fertilization stage 15th week post-fertilization stage 20th week post-fertilization stage 17th week post-fertilization stage 12th week post-fertilization stage 6-month-old stage 18th week post-fertilization stage 10-month-old stage Newborn stage (0-28 days) 24th week post-fertilization stage

Normal

Female Male

10x 5' v2 10x 5' v1 10x 3' v3 10x 3' v2

Cell

Drosophila melanogaster

Neuron Fat cell Tracheolar cell Glial cell Hemocyte Maxillary palp olfactory receptor neuron Epithelial cell Muscle cell Adult tracheocyte Tormogen cell Sensory neuron Labral sense organ mechanosensory neuron Gustatory receptor neuron of the labellum

Insect proboscis Maxillary palp

Day 5 of adulthood

Normal

Female Male

10x 3' v3

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Autosomal dominant polycystic kidney disease

Male

Slide-seqv2

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Normal

Male

Slide-seqv2

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Mus musculus

Neuron

Normal

10x 3' v3

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Lamp5 lhx6 neuron Eccentric medium spiny neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Microglial cell Thalamic excitatory neuron B cell Pericyte Cerebral cortex neuron Near-projecting glutamatergic cortical neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Fibroblast Medium spiny neuron

Lateral posterior nucleus of thalamus

42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Stromal cell Endothelial cell of lymphatic vessel Endothelial cell Leukocyte Smooth muscle cell Pericyte

Ovary

65-year-old stage 72-year-old stage 58-year-old stage 62-year-old stage 70-year-old stage

Normal

Female

10x 3' v3 Drop-seq

Cell

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Middle temporal gyrus

69-year-old stage 75-year-old stage 65-year-old stage 89-year-old stage 43-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage Adult stage 77-year-old stage 86-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron Cerebellar inhibitory gabaergic interneuron Ependymal cell Microglial cell Bergmann glial cell B cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Unipolar brush cell Fibroblast Mammillary body neuron

Dorsal tegmental nucleus

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Malignant cell

Lung Caecum Peritoneum Liver Hepatic flexure of colon Rectum Transverse colon Chest wall Descending colon Sigmoid colon

37-year-old stage 75-year-old stage 65-year-old stage 53-year-old stage 52-year-old stage 68-year-old stage 48-year-old stage 39-year-old stage 44-year-old stage 55-year-old stage 50-year-old stage 74-year-old stage 49-year-old stage 35-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 73-year-old stage 40-year-old stage

Colorectal cancer

Female Male

10x 3' v3

Cell