Homo sapiens

Smooth muscle cell of the pulmonary artery Capillary endothelial cell Endothelial cell of lymphatic vessel Glial cell Macrophage Naive thymus-derived cd4-positive, alpha-beta t cell Endocardial cell Mucosal invariant t cell Mast cell Cd16-negative, cd56-bright natural killer cell, human Adipocyte Neutrophil Monocyte Cd14-positive monocyte Cd8-positive, alpha-beta cytotoxic t cell Vein endothelial cell Dendritic cell, human Regular atrial cardiac myocyte Pericyte Endothelial cell Cardiac pacemaker cell of sinoatrial node B cell Cd8-positive, alpha-beta t cell Activated cd4-positive, alpha-beta t cell Plasma cell Fibroblast of cardiac tissue Cd14-low, cd16-positive monocyte Smooth muscle cell Endothelial cell of artery

Sinoatrial node

Fifth decade stage Third decade stage

Normal

Female Male

Visium spatial gene expression v1

Homo sapiens

Cerebral cortex endothelial cell Glial cell Macrophage Ependymal cell Mesenchymal cell Choroid plexus epithelial cell Neural cell

Choroid plexus

85-year-old stage 91-year-old stage 66-year-old stage 79-year-old stage 57-year-old stage 60-year-old stage 74-year-old stage 71-year-old stage 78-year-old stage 68-year-old stage 84-year-old stage 69-year-old stage 55-year-old stage

Malignant pancreatic neoplasm Aspiration pneumonia Influenza Covid-19

Female Male

10x 3' v3

Nucleus

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney granular cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Normal

Male

Slide-seqv2

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney granular cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Cortex of kidney

72-year-old stage

Normal

Male

Slide-seqv2

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney connecting tubule epithelial cell Parietal epithelial cell Leukocyte Kidney distal convoluted tubule epithelial cell Renal beta-intercalated cell Renal principal cell Epithelial cell of proximal tubule Podocyte Kidney capillary endothelial cell Kidney proximal straight tubule epithelial cell Connective tissue cell Kidney proximal convoluted tubule epithelial cell Renal alpha-intercalated cell

Cortex of kidney

50-year-old stage 62-year-old stage 52-year-old stage 54-year-old stage 61-year-old stage

Normal

Female Male

10x scatac-seq

Nucleus

Homo sapiens

Adipocyte of omentum tissue

Visceral abdominal adipose tissue Visceral fat

48-year-old stage 33-year-old stage Adult stage 28-year-old stage 36-year-old stage 68-year-old stage 34-year-old stage 35-year-old stage 53-year-old stage 73-year-old stage 24-year-old stage 29-year-old stage 41-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Drosophila melanogaster

Adult alary muscle cell Sensory neuron Hemocyte

Fat body

Day 3 of adulthood

Normal

Female Male

10x 3' v3

Homo sapiens

Cd4-positive helper t cell B cell Cd8-positive, alpha-beta t cell Dendritic cell Regulatory t cell Myeloid cell

Tonsil

Adult stage

Normal

Slide-seqv2

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney granular cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Macula densa epithelial cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Homo sapiens

Extravillous trophoblast Syncytiotrophoblast cell Placental villous trophoblast

Trophoblast

Normal

10x 3' v3

Cell

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney granular cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Macula densa epithelial cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Homo sapiens

Myoepithelial cell Circulating fibrocyte Ciliated epithelial cell Leukocyte Endothelial cell of uterus Stromal cell of endometrium Stromal cell Glandular secretory epithelial cell Epithelial cell Endothelial cell of venule Perivascular cell Fibro/adipogenic progenitor cell Fibroblast Decidual cell Endothelial cell of artery Uterine smooth muscle cell

Endometrium Myometrium

32-year-old stage 28-year-old stage 31-year-old stage

Normal

Female

10x 3' v3

Cell