Danio rerio

Cardiac endothelial cell Endothelial cell

Endocardium Blood vessel endothelium Lymphatic vessel endothelium

Pharyngula:high-pec Segmentation:26+ somites Pharyngula:prim-5 Hatching:pec-fin Hatching:long-pec Segmentation:20-25 somites Segmentation:14-19 somites Larval:protruding-mouth Pharyngula:prim-15 Pharyngula:prim-25

Normal

Sci-rna-seq3

Nucleus

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Endothelial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Autosomal dominant polycystic kidney disease

Male

Slide-seqv2

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Macula densa epithelial cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Autosomal dominant polycystic kidney disease

Male

Slide-seqv2

Danio rerio

Glutamatergic neuron Glial cell Gabaergic neuron Endocrine cell Neural progenitor cell Neuron Purkinje cell

Posterior neural tube Cerebellum Telencephalon Multicellular anatomical structure Adenohypophysis Neural crest Floor plate

Pharyngula:high-pec Segmentation:26+ somites Pharyngula:prim-5 Hatching:pec-fin Hatching:long-pec Segmentation:20-25 somites Segmentation:14-19 somites Larval:protruding-mouth Pharyngula:prim-15 Pharyngula:prim-25

Normal

Sci-rna-seq3

Nucleus

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney granular cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Bergmann glial cell Vascular associated smooth muscle cell Fibroblast Ependymal cell Pericyte Endothelial cell Neuron Central nervous system macrophage Choroid plexus epithelial cell

Nucleus of medulla oblongata

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Kidney cell Myofibroblast cell Mesenchymal stem cell Cd4-positive, alpha-beta t cell Lymphocyte Macrophage Mast cell Erythroid lineage cell Neutrophil Monocyte Megakaryocyte Epithelial cell of proximal tubule Conventional dendritic cell Fibroblast Podocyte Endothelial cell Mesenchymal cell Kidney loop of henle epithelial cell B cell Cd8-positive, alpha-beta t cell Kidney epithelial cell Plasmacytoid dendritic cell Neuron Natural killer cell

Kidney

9th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 10th week post-fertilization stage Embryonic stage 16th week post-fertilization stage

Normal

Female Male

10x 3' v2

Cell

Homo sapiens

Mesenchymal stem cell Kidney interstitial cell Innate lymphoid cell Kidney connecting tubule epithelial cell Cd4-positive, alpha-beta t cell Macrophage Nephron tubule epithelial cell Mast cell Erythroid lineage cell Neutrophil Monocyte Megakaryocyte Kidney collecting duct cell Epithelial cell of proximal tubule Conventional dendritic cell Endothelial cell Epithelial cell of nephron Epithelial cell of glomerular capsule B cell Cd8-positive, alpha-beta t cell Plasmacytoid dendritic cell Natural killer cell

Kidney

9th week post-fertilization stage 13th week post-fertilization stage 10th week post-fertilization stage 17th week post-fertilization stage Organogenesis stage 14th week post-fertilization stage

Normal

Female Male

10x 3' v2

Cell

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney granular cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Homo sapiens

Common myeloid progenitor Erythroid progenitor cell Classical monocyte Cd4-positive, alpha-beta t cell Non-classical monocyte Macrophage Neutrophil Monocyte Myeloid dendritic cell Granulocyte Fibroblast Hematopoietic precursor cell Hematopoietic stem cell Endothelial cell Intermediate monocyte B cell Cd8-positive, alpha-beta t cell Plasma cell Erythrocyte Regulatory t cell Mature nk t cell T cell Plasmacytoid dendritic cell Basophil Natural killer cell

Bone marrow

60-year-old stage 22-year-old stage 45-year-old stage 59-year-old stage 56-year-old stage 61-year-old stage 42-year-old stage

Normal

Female Male

Smart-seq2 10x 5' v2 10x 3' v3

Cell

Mus musculus

Tracheal epithelial cell

Tracheal epithelial cell

Mature stage

Normal

10x 3' v3

Cell

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Ependymal cell Pericyte Endothelial cell Neuron Central nervous system macrophage

Lateral nuclear group of thalamus

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus