Homo sapiens

Endothelial cell of artery Endothelial cell of lymphatic vessel Capillary endothelial cell Vein endothelial cell

Thymus

14th week post-fertilization stage 10-month-old stage 15th week post-fertilization stage 6-month-old stage 20th week post-fertilization stage 24th week post-fertilization stage 2-year-old stage 13th week post-fertilization stage 12th week post-fertilization stage 18th week post-fertilization stage 17th week post-fertilization stage 3-month-old stage Newborn stage (0-28 days)

Normal

Female Male

10x 5' v2 10x 3' v2 10x 5' v1 10x 3' v3

Cell

Drosophila melanogaster

Hemocyte

Insect proboscis Maxillary palp

Day 5 of adulthood

Normal

Female Male

10x 3' v3

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial fibroblast Leukocyte Kidney proximal convoluted tubule epithelial cell Podocyte Kidney collecting duct principal cell Macrophage Blood vessel smooth muscle cell Endothelial cell Kidney collecting duct intercalated cell Mesangial cell Kidney granular cell Kidney distal convoluted tubule epithelial cell

Kidney

6-month-old stage

Autosomal dominant polycystic kidney disease

Male

Slide-seqv2

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial fibroblast Leukocyte Kidney proximal convoluted tubule epithelial cell Macula densa epithelial cell Podocyte Kidney collecting duct principal cell Macrophage Blood vessel smooth muscle cell Endothelial cell Kidney collecting duct intercalated cell Mesangial cell Kidney distal convoluted tubule epithelial cell

Kidney

13-week-old stage

Normal

Male

Slide-seqv2

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial fibroblast Leukocyte Kidney proximal convoluted tubule epithelial cell Macula densa epithelial cell Podocyte Kidney collecting duct principal cell Macrophage Blood vessel smooth muscle cell Endothelial cell Kidney collecting duct intercalated cell Mesangial cell Kidney granular cell Kidney distal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Mus musculus

Neuron

Normal

10x 3' v3

Homo sapiens

Oligodendrocyte Natural killer cell Astrocyte T cell Medial ganglionic eminence derived interneuron Pvalb chandelier gabaergic interneuron Microglial cell Oligodendrocyte precursor cell B cell Neuron Pericyte Committed oligodendrocyte precursor Monocyte Eccentric medium spiny neuron Cerebral cortex neuron Cerebellar granule cell Intratelencephalic-projecting glutamatergic cortical neuron Vascular associated smooth muscle cell Endothelial cell Caudal ganglionic eminence derived interneuron Medium spiny neuron Thalamic excitatory neuron Central nervous system macrophage Midbrain-derived inhibitory neuron Fibroblast Lamp5 lhx6 neuron Near-projecting glutamatergic cortical neuron

Lateral posterior nucleus of thalamus

42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Leukocyte Pericyte Endothelial cell of lymphatic vessel Smooth muscle cell Stromal cell Endothelial cell

Ovary

62-year-old stage 72-year-old stage 58-year-old stage 65-year-old stage 70-year-old stage

Normal

Female

Drop-seq 10x 3' v3

Cell

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Middle temporal gyrus

43-year-old stage 68-year-old stage 88-year-old stage 86-year-old stage 82-year-old stage 83-year-old stage 60-year-old stage 75-year-old stage 80-year-old stage 77-year-old stage Adult stage 89-year-old stage 78-year-old stage 72-year-old stage 80 year-old and over stage 81-year-old stage 87-year-old stage 84-year-old stage 65-year-old stage 85-year-old stage 50-year-old stage 29-year-old stage 69-year-old stage 70-year-old stage

Dementia Normal

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

Oligodendrocyte Natural killer cell Astrocyte Bergmann glial cell T cell Pvalb chandelier gabaergic interneuron Microglial cell Oligodendrocyte precursor cell B cell Neuron Ependymal cell Pericyte Committed oligodendrocyte precursor Monocyte Cerebellar inhibitory gabaergic interneuron Cerebellar granule cell Intratelencephalic-projecting glutamatergic cortical neuron Vascular associated smooth muscle cell Endothelial cell Caudal ganglionic eminence derived interneuron Central nervous system macrophage Midbrain-derived inhibitory neuron Fibroblast Lamp5 lhx6 neuron Mammillary body neuron Unipolar brush cell

Dorsal tegmental nucleus

42-year-old stage 50-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Malignant cell

Lung Caecum Liver Descending colon Sigmoid colon Hepatic flexure of colon Chest wall Peritoneum Transverse colon Rectum

62-year-old stage 49-year-old stage 64-year-old stage 68-year-old stage 55-year-old stage 60-year-old stage 75-year-old stage 35-year-old stage 74-year-old stage 48-year-old stage 39-year-old stage 78-year-old stage 52-year-old stage 44-year-old stage 65-year-old stage 50-year-old stage 45-year-old stage 53-year-old stage 37-year-old stage 73-year-old stage 70-year-old stage 40-year-old stage 41-year-old stage

Colorectal cancer

Female Male

10x 3' v3

Cell

Homo sapiens

Dendritic cell Regulatory t cell B cell Cd8-positive, alpha-beta t cell Myeloid cell Cd4-positive helper t cell

Lymph node

Adult stage

Normal

Slide-seqv2