Homo sapiens

Oligodendrocyte precursor cell

Dorsolateral prefrontal cortex

69-year-old stage 75-year-old stage 42-year-old stage 89-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 77-year-old stage 86-year-old stage 70-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Normal

Male

Slide-seqv2

Homo sapiens

Midbrain-derived inhibitory neuron Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Amygdala excitatory neuron Committed oligodendrocyte precursor Hippocampal ca1-3 neuron Lamp5 lhx6 neuron Eccentric medium spiny neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Ependymal cell Microglial cell Pericyte Cerebral cortex neuron Near-projecting glutamatergic cortical neuron Neuron Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Sst chodl gabaergic interneuron Astrocyte Fibroblast Medium spiny neuron

Lateral amygdaloid nucleus

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Sst gabaergic interneuron

Neocortex

Adult stage

Normal

Female Male

10x 3' v3

Cell

Mus musculus

T cell Endothelial cell Schwann cell Smooth muscle cell Skeletal muscle satellite cell Macrophage Cell of skeletal muscle B cell Mesenchymal stem cell

Limb muscle

4-week-old stage 3-month-old stage 20-month-old stage and over 18-month-old stage

Normal

Female Male

10x 3' v2

Cell

Homo sapiens

Luminal cell of prostate epithelium Prostate gland microvascular endothelial cell Secretory cell Neuroendocrine cell Leukocyte Smooth muscle cell of prostate Prostate stromal cell Epithelial cell of urethra Basal cell of prostate epithelium

Transition zone of prostate Peripheral zone of prostate

29-year-old stage 57-year-old stage 72-year-old stage 74-year-old stage 31-year-old stage

Benign prostatic hyperplasia Normal

Male

10x 3' v2

Cell

Sus scrofa

Natural killer cell Erythrocyte Gamma-delta t cell Cd8-positive, alpha-beta t cell Peripheral blood mononuclear cell Plasmacytoid dendritic cell Lymphocyte Cd4-positive, alpha-beta t cell B cell Monocyte Antibody secreting cell Conventional dendritic cell

B cell T cell Myeloid cell Blood Natural killer cell Gamma-delta t cell

Normal

Male Female

10x genomics v2 Illumina

Homo sapiens

Mononuclear phagocyte

Lamina propria of small intestine Lamina propria of large intestine

66-year-old stage 74-year-old stage 63-year-old stage 76-year-old stage 83-year-old stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Amygdala excitatory neuron Committed oligodendrocyte precursor Dentate gyrus granule cell Cerebellar granule cell Hippocampal ca1-3 neuron Lamp5 lhx6 neuron Eccentric medium spiny neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Ependymal cell Microglial cell Choroid plexus epithelial cell Pericyte Cerebral cortex neuron Near-projecting glutamatergic cortical neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast Medium spiny neuron Hippocampal ca4 neuron

Hippocampal field

42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Malignant cell

Pancreatic ductal adenocarcinoma

Seq-well s3

Homo sapiens

Vip gabaergic interneuron

Neocortex

Adult stage

Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Luminal cell of prostate epithelium Prostate gland microvascular endothelial cell Secretory cell Neuroendocrine cell Leukocyte Fibroblast of connective tissue of prostate Smooth muscle cell of prostate Epithelial cell of urethra Basal cell of prostate epithelium

Transition zone of prostate Peripheral zone of prostate

29-year-old stage 31-year-old stage

Normal

Male

10x 3' v2

Cell