Homo sapiens

Myofibroblast cell Capillary endothelial cell Endothelial cell of lymphatic vessel Cd4-positive, alpha-beta t cell Macrophage Mast cell Neutrophil Monocyte Vein endothelial cell Bladder urothelial cell Fibroblast Pericyte Endothelial cell B cell Cd8-positive, alpha-beta t cell Plasma cell Erythrocyte Regulatory t cell Mature nk t cell T cell Smooth muscle cell Natural killer cell

Bladder organ

60-year-old stage 45-year-old stage 59-year-old stage 56-year-old stage 61-year-old stage

Normal

Female Male

Smart-seq2 10x 3' v3

Cell

Homo sapiens

Pulmonary alveolar type 1 cell Capillary endothelial cell Classical monocyte Endothelial cell of lymphatic vessel Cd4-positive, alpha-beta t cell Pulmonary alveolar type 2 cell Club cell Non-classical monocyte Macrophage Mesothelial cell Mast cell Basal cell Neutrophil Monocyte Myeloid dendritic cell Respiratory tract goblet cell Lung multiciliated epithelial cell Vein endothelial cell Vascular associated smooth muscle cell Pericyte Adventitial cell Intermediate monocyte B cell Cd8-positive, alpha-beta t cell Bronchial smooth muscle cell Plasma cell Mature nk t cell Plasmacytoid dendritic cell Alveolar adventitial fibroblast Basophil Pulmonary ionocyte Natural killer cell Endothelial cell of artery Serous cell of epithelium of bronchus

Lung

60-year-old stage 59-year-old stage 61-year-old stage

Normal

Female Male

Smart-seq2 10x 3' v3

Cell

Mus musculus

Endothelial cell of lymphatic vessel Macrophage Mesothelial cell Epithelial cell Monocyte Pericyte Endothelial cell B cell Dendritic cell T cell Mesenchymal stem cell of adipose tissue Natural killer cell

Obesity disorder

10x 3' v3

Homo sapiens

Myofibroblast cell Pulmonary interstitial fibroblast Cd1c-positive myeloid dendritic cell Pulmonary alveolar type 1 cell Capillary endothelial cell Classical monocyte Endothelial cell of lymphatic vessel Pulmonary alveolar type 2 cell Club cell Pulmonary neuroendocrine cell Non-classical monocyte Lymphocyte Macrophage Naive thymus-derived cd4-positive, alpha-beta t cell Alveolar macrophage Lung goblet cell Effector memory cd4-positive, alpha-beta t cell Basal cell Epithelial cell Monocyte Megakaryocyte Myeloid dendritic cell, human Lung multiciliated epithelial cell Tracheobronchial serous cell Vein endothelial cell Vascular associated smooth muscle cell Fibroblast Naive thymus-derived cd8-positive, alpha-beta t cell Effector memory cd8-positive, alpha-beta t cell Pericyte Endothelial cell Myeloid leukocyte Intermediate monocyte Mesothelial cell of pleura B cell Plasmacytoid dendritic cell, human Bronchial smooth muscle cell Dendritic cell Plasma cell Mature nk t cell Mucus secreting cell Respiratory basal cell Pulmonary ionocyte Natural killer cell Endothelial cell of artery Ciliated cell

Blood Lung

46-year-old stage 75-year-old stage 51-year-old stage

Normal

Female Male

10x 3' v2

Cell

Homo sapiens

Capillary endothelial cell Glutamatergic neuron Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Gabaergic neuron Vein endothelial cell Microglial cell Fibroblast Pericyte T cell Perivascular macrophage Smooth muscle cell Endothelial cell of artery

Dorsolateral prefrontal cortex

79-year-old stage 78-year-old stage 88-year-old stage 84-year-old stage 90 year-old and over stage 87-year-old stage 81-year-old stage 83-year-old stage

Normal Cognitive disorder Alzheimer disease

Female Male

10x multiome

Nucleus

Mus musculus

Myotendinous junction nucleus Schwann cell Lymphocyte Macrophage Skeletal muscle satellite stem cell Perineurial cell Adipocyte Intermediate muscle cell Tendon cell Type iia muscle cell Fibro/adipogenic progenitor cell Blood vessel endothelial cell Type iib muscle cell Pericyte Type iix muscle cell Smooth muscle cell Neuromuscular junction nucleus Microvascular endothelial cell

Gastrocnemius Skeletal muscle tissue of tibialis anterior

Prime adult stage

Lesion of sciatic nerve Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Transit amplifying cell Neoplastic cell Abnormal cell Tuft cell Gut absorptive cell Intestinal crypt stem cell of colon Intestinal epithelial cell Goblet cell Intestinal enteroendocrine cell

Hepatic flexure of colon Rectum Transverse colon Sigmoid colon Hepatic cecum Descending colon Ascending colon

70-year-old stage 50-year-old stage 57-year-old stage 62-year-old stage 60-year-old stage 64-year-old stage 65-year-old stage 67-year-old stage 71-year-old stage 59-year-old stage 54-year-old stage 58-year-old stage 68-year-old stage 53-year-old stage 72-year-old stage 73-year-old stage

Hyperplastic polyp Normal Colorectal neoplasm Tubular adenoma Colon sessile serrated adenoma/polyp Tubulovillous adenoma

Female Male

Trudrop

Cell

Homo sapiens

Immature t cell Stromal cell B cell Myeloid cell Mature t cell

Myasthenia gravis

10x 5' v2 10x 3' v3

Homo sapiens

Ciliated epithelial cell Club cell Ionocyte Basal cell Epithelial cell Tuft cell Hepatocyte Pulmonary alveolar epithelial cell Neuroendocrine cell Goblet cell

Axilla Adrenal gland Liver Lung Brain Pleural effusion Bone spine Lymph node

80-year-old stage 85-year-old stage 82-year-old stage 79-year-old stage 70-year-old stage 77-year-old stage 57-year-old stage 76-year-old stage 62-year-old stage 44-year-old stage 64-year-old stage 74-year-old stage 65-year-old stage 67-year-old stage 75-year-old stage 71-year-old stage 78-year-old stage 47-year-old stage 68-year-old stage 72-year-old stage 73-year-old stage 84-year-old stage 69-year-old stage 81-year-old stage 55-year-old stage

Small cell lung carcinoma Normal Lung adenocarcinoma

Female Male

10x 3' v3 10x 3' v2 10x 3' transcription profiling

Cell

Homo sapiens

Glutamatergic neuron Mature astrocyte Oligodendrocyte precursor cell Oligodendrocyte Gabaergic neuron Mature microglial cell Endothelial cell

Superior frontal gyrus

82-year-old stage 77-year-old stage 50-year-old stage 60-year-old stage 80 year-old and over stage 71-year-old stage 72-year-old stage 87-year-old stage

Normal Alzheimer disease

Male

10x 3' v2

Nucleus

Homo sapiens

Myofibroblast cell Enteric smooth muscle cell Endothelial cell of lymphatic vessel Colon epithelial cell Neural crest cell Mesothelial cell Interstitial cell of cajal Mesodermal cell Epithelial cell Stem cell Enteroendocrine cell Hematopoietic cell Progenitor cell Vein endothelial cell Fibroblast Pericyte Erythroblast Enteric neuron Enterocyte Endothelial cell of artery Intestine goblet cell

Ileum Duodeno-jejunal junction Colon

10th week post-fertilization stage Carnegie stage 22 Carnegie stage 19 Carnegie stage 23 Carnegie stage 17 Carnegie stage 18

Normal

10x 3' v2

Cell

Homo sapiens

Glutamatergic neuron Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Gabaergic neuron Lymphocyte Somatomotor neuron Microglial cell Fibroblast Ependymal cell Pericyte Endothelial cell Central nervous system macrophage

Lumbar spinal cord

80-year-old stage 67-year-old stage 75-year-old stage 68-year-old stage 73-year-old stage 83-year-old stage

Normal Amyotrophic lateral sclerosis

Female Male

10x 3' v3 10x multiome

Nucleus