Homo sapiens

Natural killer cell Cd8-positive, alpha-beta t cell Classical monocyte Plasmacytoid dendritic cell Lymphocyte Plasmablast Cd4-positive, alpha-beta t cell B cell Progenitor cell Conventional dendritic cell Non-classical monocyte

Blood

66-year-old stage 69-year-old stage 37-year-old stage 75-year-old stage 21-year-old stage 34-year-old stage 65-year-old stage 42-year-old stage 26-year-old stage 43-year-old stage 71-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 54-year-old stage 68-year-old stage 48-year-old stage 30-year-old stage 39-year-old stage 44-year-old stage 29-year-old stage 38-year-old stage 56-year-old stage 55-year-old stage 50-year-old stage 28-year-old stage 51-year-old stage 57-year-old stage 74-year-old stage 49-year-old stage 24-year-old stage 23-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 25-year-old stage 32-year-old stage 33-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 31-year-old stage 36-year-old stage 22-year-old stage 63-year-old stage 20-year-old stage 47-year-old stage 73-year-old stage 83-year-old stage 27-year-old stage 40-year-old stage

Systemic lupus erythematosus Normal

Female Male

10x 3' v2

Cell

Homo sapiens

Central memory cd4-positive, alpha-beta t cell Natural killer cell Erythrocyte Gamma-delta t cell Hematopoietic precursor cell Cd8-positive, alpha-beta t cell Platelet Peripheral blood mononuclear cell Effector memory cd4-positive, alpha-beta t cell Plasmacytoid dendritic cell Cd4-positive, alpha-beta cytotoxic t cell Naive thymus-derived cd8-positive, alpha-beta t cell Memory b cell Innate lymphoid cell Regulatory t cell Plasmablast Cd4-positive, alpha-beta t cell Cd14-positive monocyte Cd14-low, cd16-positive monocyte Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell Transitional stage b cell Central memory cd8-positive, alpha-beta t cell Naive b cell Double negative thymocyte Conventional dendritic cell Dendritic cell Cd16-negative, cd56-bright natural killer cell, human Effector memory cd8-positive, alpha-beta t cell

Blood

66-year-old stage 69-year-old stage 37-year-old stage 75-year-old stage 91-year-old stage 21-year-old stage 34-year-old stage 65-year-old stage 42-year-old stage 26-year-old stage 89-year-old stage 43-year-old stage 93-year-old stage 87-year-old stage 71-year-old stage 85-year-old stage 53-year-old stage 61-year-old stage 88-year-old stage 52-year-old stage 54-year-old stage 68-year-old stage 48-year-old stage 30-year-old stage 39-year-old stage 44-year-old stage 29-year-old stage 38-year-old stage 56-year-old stage 55-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 90-year-old stage 80-year-old stage 28-year-old stage 51-year-old stage 57-year-old stage 72-year-old stage 81-year-old stage 74-year-old stage 97-year-old stage 49-year-old stage 24-year-old stage 23-year-old stage 95-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 25-year-old stage 67-year-old stage 32-year-old stage 77-year-old stage 33-year-old stage 64-year-old stage 94-year-old stage 45-year-old stage 62-year-old stage 86-year-old stage 41-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 78-year-old stage 31-year-old stage 36-year-old stage 22-year-old stage 19-year-old stage 63-year-old stage 20-year-old stage 47-year-old stage 76-year-old stage 79-year-old stage 73-year-old stage 83-year-old stage 27-year-old stage 40-year-old stage 96-year-old stage

Normal

Female Male

10x 3' v2

Cell

Homo sapiens

Central memory cd4-positive, alpha-beta t cell T cell Cd1c-positive myeloid dendritic cell Mature gamma-delta t cell Natural killer cell Erythrocyte Platelet Cd141-positive myeloid dendritic cell Effector memory cd4-positive, alpha-beta t cell Intermediate monocyte Cd8aa(i) thymocyte Plasmacytoid dendritic cell Basophil mast progenitor cell Cd8-positive, alpha-beta memory t cell Be cell Memory regulatory t cell Naive thymus-derived cd8-positive, alpha-beta t cell Memory b cell Axl+ dendritic cell, human Cd16-positive, cd56-dim natural killer cell, human Innate lymphoid cell Common myeloid progenitor Plasma cell Naive regulatory t cell Memory ccr4-positive regulatory t cell Cd14-low, cd16-positive monocyte Cd4-positive, alpha-beta memory t cell Naive thymus-derived cd4-positive, alpha-beta t cell Common lymphoid progenitor Mucosal invariant t cell Cd8-positive, alpha-beta regulatory t cell Transitional stage b cell Cd14-positive, cd16-negative classical monocyte Central memory cd8-positive, alpha-beta t cell Naive b cell Double negative thymocyte Cd16-negative, cd56-bright natural killer cell, human Effector memory cd8-positive, alpha-beta t cell

Blood

37-year-old stage 34-year-old stage 26-year-old stage 30-year-old stage 29-year-old stage 28-year-old stage 35-year-old stage 31-year-old stage 36-year-old stage 27-year-old stage

Cytomegalovirus infection

Female

10x 3' v3

Cell

Danio rerio

Fast muscle cell Osteoblast Neutrophil Podocyte Muscle cell Adaxial cell Melanoblast Cardiac endothelial cell Hepatocyte Stromal cell Slow muscle myoblast Glutamatergic neuron Erythrocyte Nonkeratinized cell of epidermis Slow muscle cell Kolmer-agduhr neuron Olfactory epithelial cell Endothelial cell Retinal ganglion cell Retinal pigment epithelial cell Myeloid lineage restricted progenitor cell Hepatoblast Peridermal cell Ectodermal cell Hypertrophic chondrocyte Enteric neuron Spinal cord interneuron Tendon cell Migratory cranial neural crest cell Neuromast supporting cell Premigratory neural crest cell Schwann cell Taste receptor cell Melanocyte Ionocyte Smooth muscle cell Notochordal cell Epithelial cell Neuroplacodal cell Neural crest cell Connective tissue cell Muscle precursor cell Pancreatic endocrine cell Pancreatic a cell Sensory hair cell Xanthophore cell Mesodermal cell Splanchnic mesodermal cell Goblet cell Chondroblast Retinal bipolar neuron Hatching gland cell Photoreceptor cell Xanthoblast Macrophage Endocrine cell Notochordal sheath cell Pancreatic d cell Cranial motor neuron Rohon-beard neuron Migratory neural crest cell Neuroblast (sensu vertebrata) Lateral motor column neuron Glial cell Enterocyte Odontoblast Neurecto-epithelial cell Type b pancreatic cell Mesenchymal cell Fast muscle myoblast Motor neuron Retina horizontal cell Epithelial cell of distal tubule Lens epithelial cell Amacrine cell Retinal progenitor cell Glycinergic neuron Notochordal vacuole cell Myoblast Auditory epithelial supporting cell Epidermal cell Mesothelial cell Iridophore Cardiac muscle cell Endodermal cell Pericyte Lens fiber cell Neuron Thyroid follicular cell Epithelial cell of exocrine pancreas Eye photoreceptor cell Purkinje cell Multiciliated epithelial cell Kidney proximal convoluted tubule epithelial cell Primordial germ cell Gabaergic neuron Neural progenitor cell Epidermal mucus secreting cell Epithelial cell of esophagus Chondrocyte

Adenohypophysis Anterior lateral plate mesoderm Anterior segment of eyeball Blood Blood island Blood vessel endothelium Brain Bulbus arteriosus Cerebellum Cleithrum Cloaca Corpuscles of stannius Cranial ganglion Craniocervical muscle Crista ampullaris Diencephalon Distal tubule Dorsolateral placode Ear vesicle Ectoderm-derived structure Endocardium Endocrine pancreas Enteric ganglion Epibranchial ganglion Esophagus Fast muscle tissue Floor plate Forebrain Ganglionic layer of retina Genitourinary system Gonad primordium Habenula Hatching gland Head Head connective tissue Heart Heart primordium Hindbrain Hypaxial musculature Hypochord Inner nuclear layer of retina Integument Interrenal primordium Intestinal epithelium Intestine Lateral line Lateral line ganglion Lateral plate mesoderm Lens of camera-type eye Lens vesicle Leptomeninx Liver Liver primordium Lymphatic vessel endothelium Macula Median fin fold Meninx Midbrain Midbrain tectum Midbrain tegmentum Midbrain-hindbrain boundary Multicellular anatomical structure Myotome Neural crest Neural rod Notochord Olfactory epithelium Olfactory system Outer nuclear layer of retina Pancreas Pancreatic epithelial bud Parachordal cartilage Pectoral appendage bud Pectoral fin Periderm Periocular mesenchyme Pharyngeal arch Pharyngeal pouch Pharynx Pigmented layer of retina Posterior neural tube Presomitic mesoderm Proepicardium Pronephric glomerulus Pronephric mesoderm Pronephros Proximal convoluted tubule Retina Sclerotome Semicircular canal Skin epidermis Slow muscle tissue Somite Spinal cord Swim bladder Taste bud Telencephalon Thyroid follicle Tooth placode Trigeminal ganglion Trunk neural crest Ventricular zone Vestibulocochlear ganglion Zona limitans intrathalamica

Pharyngula:prim-15 Hatching:long-pec Larval:protruding-mouth Pharyngula:prim-25 Segmentation:26+ somites Segmentation:14-19 somites Hatching:pec-fin Segmentation:20-25 somites Pharyngula:high-pec Pharyngula:prim-5

Normal

Sci-rna-seq3

Nucleus

Homo sapiens

Central memory cd4-positive, alpha-beta t cell T cell Cd1c-positive myeloid dendritic cell Mature gamma-delta t cell Natural killer cell Erythrocyte Platelet Cd141-positive myeloid dendritic cell Effector memory cd4-positive, alpha-beta t cell Intermediate monocyte Cd8aa(i) thymocyte Plasmacytoid dendritic cell Basophil mast progenitor cell Cd8-positive, alpha-beta memory t cell Be cell Memory regulatory t cell Naive thymus-derived cd8-positive, alpha-beta t cell Memory b cell Axl+ dendritic cell, human Cd16-positive, cd56-dim natural killer cell, human Innate lymphoid cell Common myeloid progenitor Plasma cell Naive regulatory t cell Memory ccr4-positive regulatory t cell Cd14-low, cd16-positive monocyte Cd4-positive, alpha-beta memory t cell Naive thymus-derived cd4-positive, alpha-beta t cell Common lymphoid progenitor Mucosal invariant t cell Cd8-positive, alpha-beta regulatory t cell Transitional stage b cell Cd14-positive, cd16-negative classical monocyte Central memory cd8-positive, alpha-beta t cell Naive b cell Double negative thymocyte Cd16-negative, cd56-bright natural killer cell, human Effector memory cd8-positive, alpha-beta t cell

Blood

37-year-old stage 34-year-old stage 26-year-old stage 30-year-old stage 29-year-old stage 28-year-old stage 35-year-old stage 32-year-old stage 33-year-old stage 31-year-old stage 36-year-old stage 27-year-old stage

Cytomegalovirus infection

Male

10x 3' v3

Cell

Mus musculus

Pyramidal neuron Central nervous system macrophage Glutamatergic neuron L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex Endothelial cell Oligodendrocyte Hippocampal neuron Meis2 expressing cortical gabaergic cell Vascular leptomeningeal cell (mmus) Lamp5 gabaergic interneuron Cajal-retzius cell L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex Vip gabaergic interneuron L2/3-6 intratelencephalic projecting glutamatergic neuron L5 extratelencephalic projecting glutamatergic cortical neuron L6b glutamatergic cortical neuron L6 corticothalamic-projecting glutamatergic cortical neuron Pvalb gabaergic interneuron Pericyte L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex Sncg gabaergic interneuron Sst chodl gabaergic interneuron Astrocyte L5/6 near-projecting glutamatergic neuron of the primary motor cortex Sst gabaergic interneuron Cortical interneuron Corticothalamic-projecting glutamatergic cortical neuron

Agranular insular cortex Anterior cingulate cortex Auditory cortex Entorhinal cortex Frontal lobe Hippocampal formation Lateral visual area Medial orbital frontal cortex Parietal cortex Posterior parietal association areas Primary motor cortex Primary somatosensory cortex Primary visual cortex Retrosplenial granular cortex Subicular complex Temporal cortex Visual cortex

9-week-old stage 7-week-old stage 8-week-old stage

Normal

Female Male

10x 3' v2

Cell

Homo sapiens

Fast muscle cell T cell Neutrophil Transit amplifying cell of small intestine Bladder urothelial cell Progenitor cell of mammary luminal epithelium Club cell Granulocyte Respiratory tract goblet cell Muscle cell Cardiac endothelial cell Serous cell of epithelium of bronchus Hepatocyte Stromal cell Intestinal crypt stem cell of colon Luminal cell of prostate epithelium Endothelial cell of venule Natural killer cell Endothelial cell of lymphatic vessel Erythroid progenitor cell Erythrocyte Enterocyte of epithelium proper of small intestine Multiciliated columnar cell of tracheobronchial tree Conjunctival epithelial cell Gamma-delta t cell Thymic fibroblast type 1 Tissue-resident macrophage Slow muscle cell Enterochromaffin-like cell Activated cd4-positive, alpha-beta t cell Best4+ enterocyte Endothelial cell Mature nk t cell Stromal cell of ovary Retinal ganglion cell Hematopoietic precursor cell Colon endothelial cell Retinal pigment epithelial cell Interstitial cell of cajal Mast cell Pulmonary ionocyte Corneal epithelial cell Cd8-positive, alpha-beta t cell Myo-medullary thymic epithelial cell Pancreatic acinar cell Platelet Pancreatic pp cell Endothelial cell of arteriole Colon macrophage Blood vessel smooth muscle cell Tendon cell Myometrial cell Basal cell Luminal epithelial cell of mammary gland Erythroid lineage cell Endothelial cell of artery Capillary endothelial cell Schwann cell Taste receptor cell Melanocyte Leukocyte Classical monocyte Ionocyte Smooth muscle cell Thymic fibroblast type 2 Intermediate monocyte Enteroglial cell Epithelial cell Connective tissue cell Intestinal tuft cell Plasmacytoid dendritic cell Hepatic stellate cell Pancreatic a cell Myeloid dendritic cell Enteroendocrine cell Lung multiciliated epithelial cell Vestibular dark cell Enterocyte of epithelium proper of jejunum Endothelial cell of vascular tree Myoepithelial cell Ovarian surface epithelial cell Adipocyte Enterocyte of epithelium proper of duodenum Small intestine goblet cell Naive thymus-derived cd8-positive, alpha-beta t cell Thymocyte Retinal bipolar neuron Transit amplifying cell of colon Macrophage Tuft cell of colon Microglial cell Pancreatic d cell Paneth cell of colon Peritubular myoid cell Innate lymphoid cell Regulatory t cell Neuro-medullary thymic epithelial cell Pulmonary alveolar type 1 cell Mural cell Pancreatic stellate cell Paneth cell of epithelium of small intestine Duct epithelial cell Radial glial cell Activated cd8-positive, alpha-beta t cell Myeloid cell Bronchial smooth muscle cell Ventricular cardiac muscle cell Enteroendocrine cell of small intestine Tongue muscle cell Fibroblast of breast Spermatid Enterocyte of epithelium proper of ileum Hematopoietic stem cell Glial cell Acinar cell of salivary gland Common myeloid progenitor Plasma cell Cd4-positive, alpha-beta t cell Vein endothelial cell Type b pancreatic cell Kidney epithelial cell Cd8-positive, alpha-beta thymocyte Mesenchymal cell Glandular secretory epithelial cell Retina horizontal cell Cd4-positive, alpha-beta thymocyte Langerhans cell Oocyte T follicular helper cell Alveolar adventitial fibroblast Mesenchymal stem cell of adipose tissue Acinar cell Medullary thymic epithelial cell Epithelial cell of uterus Mesothelial cell Tracheal goblet cell Supporting cell of vestibular epithelium Ciliated epithelial cell Spermatocyte B cell Pericyte Mueller cell Naive thymus-derived cd4-positive, alpha-beta t cell Skeletal muscle satellite stem cell Male germ cell Serous cell of epithelium of trachea Neuron Mesenchymal stem cell Myeloid leukocyte Intestinal crypt stem cell of small intestine Regular atrial cardiac myocyte Adventitial cell Monocyte Eye photoreceptor cell Mucus secreting cell Vascular associated smooth muscle cell Pancreatic ductal cell Large intestine goblet cell Enterocyte of epithelium of large intestine Stratified squamous epithelial cell Myofibroblast cell Leydig cell Basophil Spermatogonium Epithelial fate stem cell Retinal blood vessel endothelial cell Fibroblast Theca cell Type l enteroendocrine cell Basal cell of prostate epithelium Fibroblast of cardiac tissue Sebocyte Hematopoietic cell Intrahepatic cholangiocyte Keratocyte Pulmonary alveolar type 2 cell Non-classical monocyte Mononuclear phagocyte Salivary gland cell

Abdominal aorta Adipose tissue Anterior part of tongue Anterior segment of eyeball Aorta Ascending colon Bladder organ Blood Bone marrow Brown adipose tissue Buccal mucosa Cardiac atrium Cardiac ventricle Chorioretinal region Conjunctiva Cornea Coronary artery Cortex of kidney Crista ampullaris Duodenum Endocrine pancreas Endometrium Exocrine pancreas Eye Eyelid Heart Heart right ventricle Ileum Inferior vena cava Inguinal lymph node Jejunum Kidney Lacrimal gland Large intestine Left coronary artery Left ovary Liver Lung Lymph node Mammary gland Mesenteric lymph node Mucosa of stomach Muscle of abdomen Muscle of pelvic diaphragm Muscularis mucosae of stomach Myometrium Ocular surface region Ovary Parotid gland Posterior part of tongue Posterior segment of eyeball Prostate gland Retinal neural layer Right cardiac atrium Right ovary Sclera Sigmoid colon Skin of abdomen Skin of body Skin of chest Small intestine Spleen Stomach Stomach smooth muscle Subcutaneous adipose tissue Sublingual gland Submandibular gland Testis Thoracic aorta Thymus Tongue Trachea Uterus Utricle of membranous labyrinth Vasculature

69-year-old stage 37-year-old stage 42-year-old stage 26-year-old stage 61-year-old stage 38-year-old stage 56-year-old stage 55-year-old stage 57-year-old stage 74-year-old stage 59-year-old stage 67-year-old stage 33-year-old stage 45-year-old stage 46-year-old stage 60-year-old stage 36-year-old stage 22-year-old stage 40-year-old stage

Normal

Female Male

10x 5' v2 Smart-seq3 Smart-seq2 10x 3' v3

Cell

Homo sapiens

Neutrophil Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Mast cell Macrophage Microglial cell Mural cell Radial glial cell Plasma cell Malignant cell B cell Mature t cell Neuron Monocyte Astrocyte Dendritic cell

Basal ganglion Brain Forebrain Frontal lobe Left frontal lobe Left parietal lobe Left temporal lobe Occipital lobe Parietal lobe Right frontal lobe Right occipital lobe Right parietal lobe Right temporal lobe Temporal lobe Temporoparietal junction

66-year-old stage 69-year-old stage 21-year-old stage 34-year-old stage 65-year-old stage 42-year-old stage 71-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 54-year-old stage 68-year-old stage 48-year-old stage 44-year-old stage 56-year-old stage 55-year-old stage 50-year-old stage 80-year-old stage 51-year-old stage 57-year-old stage 72-year-old stage 74-year-old stage 24-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage Adult stage 67-year-old stage 77-year-old stage 33-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 78-year-old stage 36-year-old stage 63-year-old stage 76-year-old stage 83-year-old stage

Glioblastoma

Female Male

Bd rhapsody whole transcriptome analysis Strt-seq 10x 5' v1 Smart-seq2 Microwell-seq 10x 3' v3 Cel-seq2 Drop-seq 10x 3' v2

Cell Nucleus

Macaca mulatta

Glutamatergic neuron

Brodmann (1909) area 19 Amygdala Anterior cingulate cortex Cerebellar vermis Cerebrocerebellum Corpus callosum Dorsolateral prefrontal cortex Entorhinal cortex Head of caudate nucleus Hippocampal formation Inferior parietal cortex Inferior temporal gyrus Lateral geniculate body Medial dorsal nucleus of thalamus Medulla oblongata Midbrain Nucleus accumbens Perirhinal cortex Pons Prefrontal cortex Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Superior parietal cortex Superior temporal sulcus Ventral lateral nucleus of thalamus

Juvenile stage Prime adult stage

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Blood vessel endothelial cell Endothelial cell Mast cell Ciliary muscle cell Schwann cell Melanocyte Lymphocyte Non-pigmented ciliary epithelial cell Macrophage Pigmented ciliary epithelial cell Trabecular meshwork cell B cell Pericyte Fibroblast Myelinating schwann cell

Ciliary body Eye trabecular meshwork Uvea

66-year-old stage 69-year-old stage 21-year-old stage 34-year-old stage 65-year-old stage 43-year-old stage 71-year-old stage 85-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 54-year-old stage 68-year-old stage 30-year-old stage 44-year-old stage 17-year-old stage 56-year-old stage 15-year-old stage 82-year-old stage 50-year-old stage 51-year-old stage 57-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 24-year-old stage 16-year-old stage 58-year-old stage 67-year-old stage 77-year-old stage 64-year-old stage 62-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 78-year-old stage 18-year-old stage 63-year-old stage 20-year-old stage 47-year-old stage 76-year-old stage 73-year-old stage 27-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Angiogenic pericyte Germinal center b cell Muscle cell Cycling t cell Dendritic cell, human Igm plasma cell Intestine goblet cell Endothelial cell of lymphatic vessel Erythrocyte Follicular dendritic cell Gamma-delta t cell Best4+ enterocyte Endothelial cell Afferent neuron Pro-b cell Interstitial cell of cajal Type g enteroendocrine cell Mast cell Iga plasma cell Enteric neuron Immature pericyte Basal cell Endothelial cell of artery Capillary endothelial cell Melanocyte Ionocyte Smooth muscle cell Paneth cell Enteroglial cell Plasmacytoid dendritic cell, human Epithelial cell Inhibitory motor neuron Peptic cell Igg plasma cell Fibroblast of gingiva Precursor b cell Enteroendocrine cell Glandular cell of esophagus Mesodermal cell Cd8-positive, alpha-beta memory t cell Myoepithelial cell Group 3 innate lymphoid cell Naive thymus-derived cd8-positive, alpha-beta t cell T-helper 17 cell Macrophage Intestinal crypt stem cell Memory b cell Cd16-positive, cd56-dim natural killer cell, human Regulatory t cell Neuroblast (sensu vertebrata) Type ec enteroendocrine cell Fibroblastic reticular cell Plasmablast Parietal cell Tuft cell of small intestine Keratinocyte Trem2-positive macrophage Acinar cell of salivary gland Enterocyte Salivary gland glandular cell Vein endothelial cell Mesenchymal cell Gastrointestinal tract (lamina propria) macrophage Motor neuron Neutrophil progenitor cell Eosinophil Megakaryocyte Langerhans cell Interneuron Transit amplifying cell T follicular helper cell Cd4-positive, alpha-beta memory t cell Mesothelial cell Pericyte Mucous neck cell of gastric gland Progenitor cell Type x enteroendocrine cell Foveolar cell of stomach Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell Monocyte Cycling basal cell Vascular associated smooth muscle cell Naive b cell Myofibroblast cell Conventional dendritic cell Fibroblast Colonocyte Cd16-negative, cd56-bright natural killer cell, human M cell of gut Effector memory cd8-positive, alpha-beta t cell

Ascending colon Body of stomach Buccal mucosa Caecum Colon Colonic epithelium Colonic mucosa Descending colon Duodenal epithelium Duodenum Epithelium of esophagus Epithelium of rectum Epithelium of small intestine Epithelium of stomach Esophagus Gingiva Ileal epithelium Ileum Ileum lamina propria Intestine Jejunum Labial gland Lamina propria of mucosa of colon Lamina propria of small intestine Mesenteric lymph node Parotid gland Periodontium Pyloric antrum Pylorus Rectosigmoid junction Rectum Sigmoid colon Small intestine Stomach Transverse colon Vermiform appendix

66-year-old stage Carnegie stage 19 37-year-old stage 75-year-old stage Pediatric stage 19th week post-fertilization stage 21-year-old stage 21st week post-fertilization stage 34-year-old stage 65-year-old stage 26-year-old stage 43-year-old stage Sixth decade stage 87-year-old stage 13th week post-fertilization stage 85-year-old stage 61-year-old stage 52-year-old stage 54-year-old stage 68-year-old stage 48-year-old stage 30-year-old stage 39-year-old stage 44-year-old stage 29-year-old stage 56-year-old stage Fifth decade stage 55-year-old stage 84-year-old stage 15th week post-fertilization stage 50-year-old stage 80-year-old stage 28-year-old stage 51-year-old stage 17th week post-fertilization stage 57-year-old stage 12-year-old stage 72-year-old stage 12th week post-fertilization stage Third decade stage 16th week post-fertilization stage 81-year-old stage 9th week post-fertilization stage 74-year-old stage 9-year-old stage 10th week post-fertilization stage 24-year-old stage 23-year-old stage 35-year-old stage Seventh decade stage 58-year-old stage Embryonic stage 59-year-old stage Adult stage 67-year-old stage 18th week post-fertilization stage Carnegie stage 17 2-month-old stage 32-year-old stage 77-year-old stage 33-year-old stage Carnegie stage 22 45-year-old stage 62-year-old stage 86-year-old stage 41-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 31-year-old stage Fourth decade stage 22-year-old stage Newborn stage (0-28 days) 63-year-old stage Carnegie stage 16 Eighth decade stage 76-year-old stage Prime adult stage 6-year-old stage Young adult stage 10-year-old stage Carnegie stage 18 4-year-old stage 11th week post-fertilization stage Juvenile stage (5-14 yo)

Normal

Female Male

10x 3' v1 10x 5' v2 10x 5' transcription profiling 10x 5' v1 10x 3' v3 10x 3' v2

Cell

Mus musculus musculus

Oligodendrocyte precursor cell Oligodendrocyte Ependymal cell Macrophage Microglial cell Brain microvascular endothelial cell Glial cell Neuron Astrocyte Fibroblast

Normal

10x 3' v3