Homo sapiens

Medial ganglionic eminence derived gabaergic interneuron L2/3 intratelencephalic projecting glutamatergic neuron L5/6 near-projecting glutamatergic neuron Glutamatergic neuron Oligodendrocyte precursor cell L5 intratelencephalic projecting glutamatergic neuron Oligodendrocyte Amygdala excitatory neuron Committed oligodendrocyte precursor Hippocampal ca1-3 neuron Dentate gyrus neuron Lamp5 gabaergic interneuron Brain vascular cell Microglial cell Caudal ganglionic eminence derived interneuron Astrocyte Fibroblast

Temporal cortex Frontal lobe Hippocampal formation Amygdala

15-year-old stage 9-year-old stage 14-year-old stage 11-year-old stage 6-year-old stage 10-year-old stage

Normal

Female Male

10x multiome

Nucleus

Homo sapiens

Tracheobronchial smooth muscle cell Club cell Tracheobronchial serous cell Natural killer cell Erythrocyte Non-myelinating schwann cell Gamma-delta t cell Neuroendocrine cell Mature nk t cell Mast cell Pulmonary ionocyte Iga plasma cell Blood vessel smooth muscle cell Lymph node lymphatic vessel endothelial cell Endothelial cell of artery Capillary endothelial cell Smooth muscle cell Respiratory tract epithelial cell Plasmacytoid dendritic cell Igg plasma cell Cd8-positive, alpha-beta memory t cell Myoepithelial cell Lung macrophage Goblet cell Macrophage Memory b cell Innate lymphoid cell Regulatory t cell Deuterosomal cell Pulmonary alveolar type 1 cell Plasmablast Respiratory basal cell Simple columnar epithelial cell Fibroblast of lung Alveolar macrophage Cd4-positive, alpha-beta t cell Vein endothelial cell Cd14-positive monocyte Megakaryocyte Cd14-low, cd16-positive monocyte Cd4-positive, alpha-beta memory t cell Mesothelial cell Ciliated epithelial cell Pericyte Mucosal invariant t cell Pulmonary artery endothelial cell Tracheobronchial chondrocyte Mucus secreting cell Naive b cell Myofibroblast cell Conventional dendritic cell Fibroblast Myelinating schwann cell Pulmonary alveolar type 2 cell Effector memory cd8-positive, alpha-beta t cell Lung pericyte Chondrocyte

Bronchus Lung Trachea Upper lobe of left lung Lower lobe of left lung

75-year-old stage 29-year-old stage Seventh decade stage Post-juvenile adult stage 64-year-old stage

Normal

Mixed sex Female Male

10x genomics v2 10x genomics v3

Mus musculus

T cell Natural killer cell Endothelial cell Smooth muscle cell Macrophage Microglial cell Choroid plexus epithelial cell Pericyte Fibroblast Dendritic cell

Normal Alzheimer disease

10x 3' v3

Homo sapiens

Blood vessel endothelial cell Stromal cell Endothelial cell of lymphatic vessel Mast cell Cd8-positive, alpha-beta t cell Stratified epithelial cell Epithelial cell Cd8-positive, alpha-beta cytotoxic t cell Epithelial cell of stratum germinativum of esophagus Cd4-positive, alpha-beta t cell B cell Immature b cell Mucus secreting cell Dendritic cell Mononuclear phagocyte

Epithelium of esophagus

Sixth decade stage Fifth decade stage Seventh decade stage Fourth decade stage

Normal

Female Male

10x 3' v2

Cell

Danio rerio

Glutamatergic neuron Neuroblast (sensu vertebrata) Glial cell Neuron Neural progenitor cell

Hindbrain Ventricular zone Multicellular anatomical structure Spinal cord Forebrain

Pharyngula:prim-15 Hatching:long-pec Larval:protruding-mouth Pharyngula:prim-25 Segmentation:26+ somites Segmentation:14-19 somites Hatching:pec-fin Segmentation:20-25 somites Pharyngula:high-pec Pharyngula:prim-5

Normal

Sci-rna-seq3

Nucleus

Homo sapiens

Muscle cell Type ii muscle cell Type i muscle cell

Intercostal muscle

Sixth decade stage Third decade stage Seventh decade stage Fourth decade stage Eighth decade stage Young adult stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell Nucleus

Homo sapiens

Astrocyte of the cerebral cortex

Dorsolateral prefrontal cortex

69-year-old stage 75-year-old stage 42-year-old stage 89-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 77-year-old stage 86-year-old stage 70-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Callithrix jacchus

Gabaergic neuron

Brodmann (1909) area 25 Dorsolateral prefrontal cortex Prefrontal cortex

Late adult stage Prime adult stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Neutrophil Merkel cell Blood vessel endothelial cell Natural killer cell Endothelial cell of lymphatic vessel Mast cell Cd8-positive, alpha-beta t cell Adult skeletal muscle myoblast Cd4-positive helper t cell Schwann cell Melanocyte Myoepithelial cell Macrophage Mural cell Keratinocyte Acinar cell of salivary gland Plasma cell Salivary gland glandular cell Langerhans cell B cell Fibroblast Dendritic cell

Gingiva Mucosa of lip Buccal mucosa Hard palate Soft palate

21-year-old stage 34-year-old stage 65-year-old stage Sixth decade stage 61-year-old stage 39-year-old stage 56-year-old stage 28-year-old stage 51-year-old stage 57-year-old stage 24-year-old stage 35-year-old stage Seventh decade stage 32-year-old stage 33-year-old stage 31-year-old stage 22-year-old stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Stromal cell of endometrium Perivascular cell Uterine smooth muscle cell Fibro/adipogenic progenitor cell Decidual cell Fibroblast

Endometrium Myometrium

37-year-old stage 26-year-old stage 29-year-old stage 28-year-old stage 23-year-old stage 32-year-old stage 31-year-old stage Young adult stage

Normal

Female

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Thalamic excitatory neuron

Subthalamic nucleus Medial geniculate body Anterior nuclear group Centromedian nucleus of thalamus Intralaminar nuclear group Medial dorsal nucleus of thalamus Globus pallidus Midbrain nucleus Piriform cortex Lateral nuclear group of thalamus Central amygdaloid nucleus Ventral anterior nucleus of thalamus Septal nuclear complex Epithalamus Midbrain tectum Substantia nigra Gray matter of midbrain Accessory basal amygdaloid nucleus Pulvinar nucleus Hypothalamus Primary motor cortex Medial zone of hypothalamus Dentate gyrus of hippocampal formation Lateral posterior nucleus of thalamus Bed nucleus of stria terminalis Lateral geniculate body Pretectal region Nucleus of dorsal thalamus

42-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Neutrophil Natural killer cell Erythrocyte Mature nk t cell Hematopoietic precursor cell Cd8-positive, alpha-beta t cell Platelet Classical monocyte Intermediate monocyte Plasmacytoid dendritic cell Myeloid dendritic cell Macrophage Regulatory t cell Hematopoietic stem cell Common myeloid progenitor Plasma cell Cd4-positive, alpha-beta t cell B cell Naive thymus-derived cd4-positive, alpha-beta t cell Monocyte Basophil Non-classical monocyte

Blood

69-year-old stage 61-year-old stage 56-year-old stage 59-year-old stage 33-year-old stage 45-year-old stage 60-year-old stage

Normal

Female Male

10x 5' v2 Smart-seq2 10x 3' v3

Cell