Homo sapiens

Capillary endothelial cell Naive b cell Mural cell Endothelial cell of lymphatic vessel Cd4-positive, alpha-beta t cell Muscle cell Endothelial cell of arteriole Macrophage Myelinating schwann cell Skeletal muscle satellite stem cell Mesothelial cell Type ii muscle cell Mast cell Cd16-negative, cd56-bright natural killer cell, human Perineurial cell Adipocyte Naive t cell Non-myelinating schwann cell Tendon cell Cd14-positive, cd16-low monocyte Vein endothelial cell Conventional dendritic cell Fibroblast Blood vessel endothelial cell Pericyte Fibroblast of the aortic adventitia B cell Cd8-positive, alpha-beta t cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell Plasma cell Erythrocyte T cell Memory b cell Plasmacytoid dendritic cell Cd14-low, cd16-positive monocyte Smooth muscle cell Eosinophil Natural killer cell Endothelial cell of artery Immature neutrophil Cd16-positive, cd56-dim natural killer cell, human Type i muscle cell Mature neutrophil

Intercostal muscle

Young adult stage Fourth decade stage Eighth decade stage Seventh decade stage Third decade stage Sixth decade stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell Nucleus

Homo sapiens

Igg plasma cell Cd4-positive, alpha-beta t cell Iga plasma cell Macrophage Mature b cell Effector cd8-positive, alpha-beta t cell Monocyte Granulocyte Cd8-positive, alpha-beta memory t cell Conventional dendritic cell Group 3 innate lymphoid cell T-helper 17 cell Cd8-positive, alpha-beta t cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell Activated cd4-positive, alpha-beta t cell Dendritic cell Mature nk t cell T cell Plasmacytoid dendritic cell T follicular helper cell Natural killer cell Gamma-delta t cell Mature conventional dendritic cell Germinal center b cell

Colorectum

91-year-old stage 82-year-old stage 70-year-old stage 77-year-old stage 50-year-old stage 57-year-old stage 76-year-old stage 62-year-old stage 52-year-old stage 60-year-old stage 48-year-old stage 64-year-old stage 89-year-old stage 45-year-old stage 67-year-old stage 71-year-old stage 78-year-old stage 36-year-old stage 59-year-old stage 47-year-old stage 56-year-old stage 58-year-old stage 61-year-old stage 51-year-old stage 49-year-old stage 42-year-old stage 35-year-old stage 53-year-old stage 72-year-old stage 73-year-old stage 84-year-old stage 90-year-old stage 69-year-old stage 81-year-old stage 55-year-old stage

Normal Colon adenocarcinoma

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Endothelial cell of arteriole Macrophage Myelinating schwann cell Mast cell Endothelial cell of venule Non-myelinating schwann cell Monocyte Blood vessel smooth muscle cell Fibroblast Pericyte B cell Dendritic cell Plasma cell T cell Fenestrated endothelial cell Retinal pigment epithelial cell Natural killer cell Melanocyte

Eyeball of camera-type eye Pigmented layer of retina Chorioretinal region Optic choroid

80-year-old stage 27th week post-fertilization stage 82-year-old stage 79-year-old stage 6-month-old stage 77-year-old stage 13th week post-fertilization stage 12th week post-fertilization stage 86-year-old stage 76-year-old stage 10th week post-fertilization stage 52-year-old stage 80 year-old and over stage 64-year-old stage 89-year-old stage 40-year-old stage 1-month-old stage 75-year-old stage 11th week post-fertilization stage 21st week post-fertilization stage 78-year-old stage 19th week post-fertilization stage 63-year-old stage 17th week post-fertilization stage 54-year-old stage 15th week post-fertilization stage 22nd week post-fertilization stage 61-year-old stage 16th week post-fertilization stage 24th week post-fertilization stage 88-year-old stage 84-year-old stage 39-year-old stage Newborn stage (0-28 days) 43-year-old stage 41-year-old stage 81-year-old stage 83-year-old stage 11-year-old stage

Normal

Female Male

10x 5' v2 10x 3' v3 10x 3' v2

Cell

Homo sapiens

Cerebellar granule cell Unipolar brush cell Brain vascular cell Cerebellar granule cell precursor Glutamatergic neuron Oligodendrocyte precursor cell Oligodendrocyte Gabaergic neuron Leukocyte Meningeal macrophage Neuroblast (sensu vertebrata) Noradrenergic cell Immature astrocyte Erythroid lineage cell Committed oligodendrocyte precursor Bergmann glial cell Interneuron Progenitor cell Microglial cell Macroglial cell T cell Purkinje cell Central nervous system macrophage Glioblast

Cerebellum Cerebellar cortex Dentate nucleus Cerebellum vermis lobule Hemisphere part of cerebellar posterior lobe

9th week post-fertilization stage 6-month-old stage 46-year-old stage 52-year-old stage Carnegie stage 22 44-year-old stage 11th week post-fertilization stage 20th week post-fertilization stage 17th week post-fertilization stage Carnegie stage 19 42-year-old stage 7-month-old stage 9-month-old stage 3-year-old stage Newborn stage (0-28 days) Carnegie stage 18

Congenital heart disease Normal Acute myocardial infarction Heart failure

Female Male

10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

Cardiac neuron Cardiac atrium fibroblast Cardiac endothelial cell Cardiac muscle cell Endothelial cell of lymphatic vessel Macrophage Mesothelial cell Mast cell Adipocyte Megakaryocyte Vascular associated smooth muscle cell Pericyte B cell T cell

Normal Atrial fibrillation

10x 3' v3

Homo sapiens

Oligodendrocyte

Substantia nigra pars compacta

91-year-old stage 82-year-old stage 79-year-old stage 70-year-old stage 76-year-old stage 89-year-old stage 74-year-old stage 92-year-old stage 75-year-old stage 78-year-old stage 49-year-old stage 90-year-old stage 83-year-old stage

Normal Lewy body dementia Parkinson disease

Female Male

10x 3' v3

Nucleus

Homo sapiens

Cerebellar neuron Direct pathway medium spiny neuron Sncg gabaergic interneuron Sst gabaergic interneuron Lamp5 gabaergic interneuron Indirect pathway medium spiny neuron Central nervous system neuron Thalamic excitatory neuron Purkinje cell Vip gabaergic interneuron Pvalb gabaergic interneuron Pvalb chandelier gabaergic interneuron

Middle temporal gyrus Putamen Brodmann (1909) area 24 Posterior parahippocampal gyrus Brodmann (1909) area 38 Secondary visual cortex Brodmann (1909) area 19 Inferior temporal gyrus Hippocampal formation Dentate gyrus of hippocampal formation Bed nucleus of stria terminalis Primary somatosensory cortex Substantia innominata Body of caudate nucleus Cerebellum Insula Central nucleus of inferior colliculus Central amygdaloid nucleus Granular insular cortex Agranular insular cortex Globus pallidus Basolateral amygdaloid nuclear complex Anterior cingulate cortex Subiculum Primary auditory cortex Medial entorhinal cortex Corticomedial nuclear complex Brodmann (1909) area 46 Lateral entorhinal cortex Brodmann (1909) area 25 Parietal cortex Primary motor cortex Pulvinar nucleus Amygdala Primary visual cortex Hippocampal field Piriform cortex Claustrum of brain Pontine nuclear group Medial dorsal nucleus of thalamus Nucleus accumbens Septal nuclear complex Prefrontal cortex Cuneus cortex

58-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

Snmc-seq2

Nucleus

Homo sapiens

Cerebellar neuron Direct pathway medium spiny neuron Sncg gabaergic interneuron Sst gabaergic interneuron Lamp5 gabaergic interneuron Indirect pathway medium spiny neuron Central nervous system neuron Thalamic excitatory neuron Purkinje cell Vip gabaergic interneuron Pvalb gabaergic interneuron Pvalb chandelier gabaergic interneuron

Middle temporal gyrus Putamen Brodmann (1909) area 24 Posterior parahippocampal gyrus Brodmann (1909) area 38 Secondary visual cortex Brodmann (1909) area 19 Inferior temporal gyrus Hippocampal formation Dentate gyrus of hippocampal formation Bed nucleus of stria terminalis Primary somatosensory cortex Substantia innominata Body of caudate nucleus Cerebellum Insula Central nucleus of inferior colliculus Central amygdaloid nucleus Granular insular cortex Agranular insular cortex Globus pallidus Basolateral amygdaloid nuclear complex Anterior cingulate cortex Subiculum Primary auditory cortex Medial entorhinal cortex Corticomedial nuclear complex Brodmann (1909) area 46 Lateral entorhinal cortex Brodmann (1909) area 25 Parietal cortex Primary motor cortex Pulvinar nucleus Amygdala Primary visual cortex Hippocampal field Piriform cortex Claustrum of brain Pontine nuclear group Medial dorsal nucleus of thalamus Nucleus accumbens Septal nuclear complex Prefrontal cortex Cuneus cortex

58-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

Snmc-seq2

Nucleus

Danio rerio

Neuromast supporting cell Taste receptor cell Endodermal cell Epithelial cell Olfactory epithelial cell Odontoblast Neuroplacodal cell Thyroid follicular cell

Genitourinary system Dorsolateral placode Lateral line Tooth placode Pharyngeal arch Olfactory epithelium Multicellular anatomical structure Pharynx Thyroid follicle Pharyngeal pouch Taste bud

Pharyngula:high-pec Segmentation:26+ somites Pharyngula:prim-5 Hatching:pec-fin Hatching:long-pec Segmentation:20-25 somites Segmentation:14-19 somites Larval:protruding-mouth Pharyngula:prim-15 Pharyngula:prim-25

Normal

Sci-rna-seq3

Nucleus

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney connecting tubule epithelial cell Parietal epithelial cell Papillary tips cell Non-classical monocyte Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Mast cell Kidney loop of henle thin descending limb epithelial cell Renal interstitial pericyte Neutrophil Kidney interstitial alternatively activated macrophage Epithelial cell of proximal tubule Kidney collecting duct intercalated cell Conventional dendritic cell Podocyte Endothelial cell B cell Plasmacytoid dendritic cell, human Plasma cell Mature nk t cell T cell Neural cell Mononuclear phagocyte Kidney loop of henle thin ascending limb epithelial cell

Renal medulla Cortex of kidney Renal papilla

66-year-old stage Fourth decade stage 57-year-old stage 76-year-old stage 45-year-old stage Eighth decade stage 14-year-old stage 63-year-old stage 59-year-old stage 54-year-old stage Seventh decade stage 69-year-old stage Third decade stage 29-year-old stage Sixth decade stage

Normal Chronic kidney disease Acute kidney failure

Female Male

10x 3' v3

Nucleus

Homo sapiens

Common myeloid progenitor Promonocyte Innate lymphoid cell Double-positive, alpha-beta thymocyte Naive thymus-derived cd4-positive, alpha-beta t cell Granulocyte monocyte progenitor cell Megakaryocyte-erythroid progenitor cell Fraction a pre-pro b cell Megakaryocyte Double negative thymocyte Early lymphoid progenitor Naive thymus-derived cd8-positive, alpha-beta t cell Group 3 innate lymphoid cell Hematopoietic stem cell Cd8-alpha-alpha-positive, alpha-beta intraepithelial t cell Group 2 innate lymphoid cell Regulatory t cell T cell Natural killer cell Hematopoietic multipotent progenitor cell

Thymus Mesenteric lymph node Liver Spleen Kidney Bone marrow Gut wall Yolk sac Skin of body

9th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 22 11th week post-fertilization stage 17th week post-fertilization stage 15th week post-fertilization stage Carnegie stage 19 Carnegie stage 13 14th week post-fertilization stage 16th week post-fertilization stage Carnegie stage 23 Carnegie stage 20

Normal

Female Male

10x 5' v1 10x 3' v2

Cell

Homo sapiens

L2/3 intratelencephalic projecting glutamatergic neuron Inhibitory interneuron Vascular leptomeningeal cell Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Macrophage L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex Erythroid lineage cell L6 corticothalamic-projecting glutamatergic cortical neuron L5/6 near-projecting glutamatergic neuron of the primary motor cortex Sst gabaergic interneuron Microglial cell Lamp5 gabaergic interneuron L6b glutamatergic cortical neuron Pericyte Endothelial cell B cell T cell Smooth muscle cell L5 extratelencephalic projecting glutamatergic cortical neuron Vip gabaergic interneuron Pvalb gabaergic interneuron Pvalb chandelier gabaergic interneuron Myeloid cell

Dorsolateral prefrontal cortex

19-year-old stage 50-year-old stage 64-year-old stage 36-year-old stage

Normal

Female Male

10x 3' v3

Nucleus