Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney inner medulla collecting duct epithelial cell Mural cell Classical monocyte Endothelial cell of lymphatic vessel Kidney connecting tubule epithelial cell Parietal epithelial cell Non-classical monocyte Lymphocyte Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Kidney loop of henle thin descending limb epithelial cell Kidney arterial blood vessel cell Epithelial cell of proximal tubule Dendritic cell, human Kidney collecting duct intercalated cell Vascular associated smooth muscle cell Conventional dendritic cell Podocyte Glomerular capillary endothelial cell B cell Peritubular capillary endothelial cell T cell Renal medullary fibroblast Vasa recta cell Natural killer cell Myeloid cell Kidney loop of henle thin ascending limb epithelial cell

Renal medulla Cortex of kidney Renal pelvis Kidney Renal papilla

66-year-old stage 70-year-old stage 50-year-old stage 57-year-old stage 76-year-old stage 62-year-old stage 46-year-old stage 52-year-old stage 60-year-old stage 44-year-old stage 48-year-old stage 64-year-old stage 45-year-old stage 74-year-old stage 67-year-old stage 40-year-old stage Eighth decade stage 71-year-old stage 63-year-old stage 59-year-old stage 54-year-old stage 47-year-old stage 31-year-old stage 56-year-old stage 58-year-old stage 68-year-old stage 61-year-old stage 49-year-old stage 42-year-old stage 35-year-old stage 53-year-old stage 72-year-old stage 30-year-old stage Seventh decade stage 39-year-old stage 69-year-old stage 43-year-old stage 29-year-old stage 41-year-old stage

Normal

Female Male

10x 5' v1 10x 3' v3 10x 3' v2

Nucleus Cell

Mus musculus

Circulating fibrocyte Kupffer cell Schwann cell Cardiac muscle cell Kidney tubule cell Macrophage Endocardial cell Type b pancreatic cell Pancreatic d cell Neutrophil Monocyte Granulocyte Fibroblast Hepatocyte Exocrine cell Pericyte Endothelial cell Pancreatic pp cell Pancreatic a cell B cell Hepatic stellate cell Dendritic cell Mature nk t cell T cell Natural killer cell

Blood Liver Kidney Pancreas Heart

2-month-old stage

Normal Myocardial infarction

Male

10x 3' v3

Cell

Homo sapiens

Bronchus fibroblast of lung Myofibroblast cell Myoepithelial cell Smooth muscle cell of the pulmonary artery Serous secreting cell of bronchus submucosal gland Pulmonary alveolar type 1 cell Lung resident memory cd4-positive, alpha-beta t cell Naive b cell Igg plasma cell Innate lymphoid cell Endothelial cell of lymphatic vessel Pulmonary alveolar type 2 cell Club cell Lung resident memory cd8-positive, alpha-beta t cell Iga plasma cell Naive thymus-derived cd4-positive, alpha-beta t cell Myelinating schwann cell Mesothelial cell Alveolar macrophage Metallothionein-positive alveolar macrophage Mucosal invariant t cell Mast cell Basal cell Epithelial cell Lung interstitial macrophage Non-myelinating schwann cell Monocyte Megakaryocyte Pulmonary artery endothelial cell Cd14-positive monocyte Blood vessel smooth muscle cell Plasmablast Vein endothelial cell Conventional dendritic cell Fibroblast Blood vessel endothelial cell Effector memory cd8-positive, alpha-beta t cell Deuterosomal cell Adventitial cell Effector cd4-positive, alpha-beta t cell Lung macrophage Airway submucosal gland duct basal cell Lung pericyte Dendritic cell Erythrocyte Regulatory t cell Memory b cell Plasmacytoid dendritic cell Lung perichondrial fibroblast Neuroendocrine cell Fibroblast of lung Smooth muscle cell Lung secretory cell Natural killer cell Chondrocyte Endothelial cell of artery Gamma-delta t cell Ciliated cell Goblet cell Respiratory tract suprabasal cell

Lung Bronchus Upper lobe of left lung Trachea Lower lobe of left lung

66-year-old stage 64-year-old stage 75-year-old stage 59-year-old stage 58-year-old stage 35-year-old stage Seventh decade stage 29-year-old stage Sixth decade stage

Normal

Female Male

10x 3' v3 10x 5' transcription profiling 10x 3' v2

Cell Nucleus

Mus musculus

Glial cell Macrophage Neutrophil Fibroblast Sensory neuron of dorsal root ganglion Pericyte Endothelial cell B cell Connective tissue cell Smooth muscle cell

Dorsal root ganglion

15-month-old stage 8-week-old stage

Normal Peripheral neuropathy

Female Male

Smart-seq2 10x 3' v3 Indrop Smart-seq3 10x multiome 10x 3' v2

Nucleus Cell

Homo sapiens

Cardiac endothelial cell Smooth muscle myoblast Mast cell Lymphoid lineage restricted progenitor cell Immature innate lymphoid cell Adipocyte of epicardial fat of left ventricle Pericyte Neuronal receptor cell Fibroblast of cardiac tissue Cardiac muscle myoblast

Heart left ventricle

66-year-old stage 57-year-old stage 52-year-old stage 60-year-old stage 44-year-old stage 64-year-old stage 74-year-old stage 40-year-old stage 63-year-old stage 59-year-old stage 47-year-old stage 58-year-old stage 61-year-old stage 51-year-old stage 43-year-old stage 38-year-old stage 55-year-old stage

Normal Myocardial infarction

Female Male

10x 3' v3

Nucleus

Homo sapiens

Granzyme k-associated cd8 t cell Naive b cell Class switched memory b cell Naive regulatory t cell Lymph node macrophage Macrophage Naive thymus-derived cd4-positive, alpha-beta t cell Cd4-positive, alpha-beta memory t cell, cd45ro-positive Mucosal invariant t cell Transitional stage b cell Mast cell Marginal zone b cell of lymph node Cd16-negative, cd56-bright natural killer cell, human Cd14-positive, cd16-low monocyte Dendritic cell, human Group 3 innate lymphoid cell, human Double negative memory b cell Fibroblast Naive thymus-derived cd8-positive, alpha-beta t cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell Plasmacytoid dendritic cell, human Plasma cell Cd14-low, cd16-positive monocyte T follicular helper cell Gamma-delta t cell Cd16-positive, cd56-dim natural killer cell, human Germinal center b cell

Axillary lymph node

19-year-old stage 21-year-old stage 32-year-old stage 50-year-old stage 22-year-old stage 40-year-old stage 27-year-old stage 34-year-old stage 35-year-old stage 24-year-old stage 38-year-old stage 41-year-old stage

Normal

Female Male

10x 5' v2

Cell

Homo sapiens

Supporting cell Mesothelial cell Leydig cell Sertoli cell Ovarian surface epithelial cell Interstitial cell of ovary Mesenchymal cell Granulosa cell

Gonad

9th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 10th week post-fertilization stage 11th week post-fertilization stage 21st week post-fertilization stage 19th week post-fertilization stage 17th week post-fertilization stage 15th week post-fertilization stage Carnegie stage 19 14th week post-fertilization stage 16th week post-fertilization stage 18th week post-fertilization stage Carnegie stage 23 Carnegie stage 17 Carnegie stage 21 Carnegie stage 18

Normal

Female Male

10x 5' v1

Cell

Homo sapiens

Cd4-positive, alpha-beta t cell Mucosal invariant t cell Stem cell Monocyte B cell Cd8-positive, alpha-beta t cell Dendritic cell T cell Natural killer cell Gamma-delta t cell

Blood

Fourth decade stage Fifth decade stage Seventh decade stage Sixth decade stage

Normal Covid-19

Female Male

10x 5' v2 10x 5' v1

Cell

Homo sapiens

Retinal rod cell Schwann cell Mural cell Astrocyte Muscle cell Retinal cone cell Mast cell Fibroblast Endothelial cell B cell Mueller cell Retinal bipolar neuron Mature nk t cell T cell Amacrine cell Retinal pigment epithelial cell Retinal ganglion cell Retina horizontal cell Melanocyte Myeloid cell

Normal Age-related macular degeneration

Homo sapiens

Radial glial cell Oligodendrocyte Neuroblast (sensu vertebrata) Neuroblast (sensu nematoda and protostomia) Neuron Glioblast

Dorsal plus ventral thalamus Hypothalamus Diencephalon

9th week post-fertilization stage 15th week post-fertilization stage Carnegie stage 20

Normal

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Sst gabaergic interneuron Pvalb gabaergic interneuron Pvalb chandelier gabaergic interneuron

Middle temporal gyrus Primary somatosensory cortex Anterior cingulate cortex Primary auditory cortex Dorsolateral prefrontal cortex Primary motor cortex Primary visual cortex Angular gyrus

50-year-old stage 60-year-old stage 42-year-old stage 43-year-old stage 29-year-old stage Sixth decade stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Cd8-positive, alpha-beta t cell

T cell

Fourth decade stage Eighth decade stage Ninth decade stage Fifth decade stage Seventh decade stage Third decade stage Sixth decade stage

B-cell non-hodgkin lymphoma

Female Male

10x 5' v1

Cell