Homo sapiens

Podocyte Natural killer cell Endothelial cell of lymphatic vessel Endothelial cell Cd8-positive, alpha-beta t cell Iga plasma cell Igg plasma cell Epithelial cell of proximal tubule segment 1 Macrophage Kidney collecting duct principal cell Kidney connecting tubule principal cell Kidney loop of henle thick ascending limb epithelial cell Pericyte Naive thymus-derived cd4-positive, alpha-beta t cell Collagen secreting cell Kidney loop of henle ascending limb epithelial cell Conventional dendritic cell Fibroblast

Kidney

Sixth decade stage

Nonpapillary renal cell carcinoma

Male

Visium spatial gene expression v1

Homo sapiens

Podocyte Endothelial cell of lymphatic vessel Endothelial cell Mast cell Cd8-positive, alpha-beta t cell Iga plasma cell Epithelial cell of proximal tubule Igg plasma cell Epithelial cell of proximal tubule segment 1 Macrophage Kidney collecting duct principal cell Kidney connecting tubule principal cell Kidney loop of henle thick ascending limb epithelial cell Mhc-ii-positive classical monocyte Naive thymus-derived cd4-positive, alpha-beta t cell Collagen secreting cell Kidney loop of henle ascending limb epithelial cell Fibroblast Non-classical monocyte

Kidney

Seventh decade stage

Nonpapillary renal cell carcinoma

Male

Visium spatial gene expression v1

Homo sapiens

Epithelial cell of proximal tubule segment 1 Macrophage Kidney pelvis urothelial cell Kidney loop of henle thick ascending limb epithelial cell Epithelial cell of proximal tubule segment 3 Naive thymus-derived cd4-positive, alpha-beta t cell Collagen secreting cell Fibroblast

Kidney

Sixth decade stage

Nonpapillary renal cell carcinoma

Male

Visium spatial gene expression v1

Homo sapiens

Endothelial cell Epithelial cell of proximal tubule Epithelial cell of proximal tubule segment 1 Macrophage Kidney loop of henle thick ascending limb epithelial cell Pericyte Naive thymus-derived cd4-positive, alpha-beta t cell Fibroblast

Kidney

Eighth decade stage

Nonpapillary renal cell carcinoma

Female

Visium spatial gene expression v1

Homo sapiens

Endothelial cell Cd8-positive, alpha-beta t cell Iga plasma cell Epithelial cell of proximal tubule Epithelial cell of proximal tubule segment 1 Macrophage Kidney loop of henle thick ascending limb epithelial cell Mhc-ii-positive classical monocyte Epithelial cell of proximal tubule segment 3 Pericyte Naive thymus-derived cd4-positive, alpha-beta t cell Collagen secreting cell Conventional dendritic cell Fibroblast

Kidney

Sixth decade stage

Nonpapillary renal cell carcinoma

Female

Visium spatial gene expression v1

Homo sapiens

Podocyte Natural killer cell Endothelial cell Cd8-positive, alpha-beta t cell Activated type ii nk t cell Classical monocyte Epithelial cell of proximal tubule Epithelial cell Epithelial cell of proximal tubule segment 1 Macrophage Kidney collecting duct principal cell Kidney connecting tubule principal cell Kidney loop of henle thick ascending limb epithelial cell Mhc-ii-positive classical monocyte Epithelial cell of proximal tubule segment 3 Pericyte Naive thymus-derived cd4-positive, alpha-beta t cell Collagen secreting cell Kidney loop of henle ascending limb epithelial cell Fibroblast

Kidney

Eighth decade stage

Nonpapillary renal cell carcinoma

Female

Visium spatial gene expression v1

Homo sapiens

Podocyte Natural killer cell Endothelial cell of lymphatic vessel Endothelial cell Iga plasma cell Classical monocyte Epithelial cell of proximal tubule Epithelial cell of proximal tubule segment 1 Macrophage Kidney collecting duct principal cell Kidney connecting tubule principal cell Kidney loop of henle thick ascending limb epithelial cell Epithelial cell of proximal tubule segment 3 Pericyte Naive thymus-derived cd4-positive, alpha-beta t cell Collagen secreting cell Kidney loop of henle ascending limb epithelial cell Fibroblast

Kidney

Seventh decade stage

Nonpapillary renal cell carcinoma

Male

Visium spatial gene expression v1

Homo sapiens

Podocyte Renal beta-intercalated cell Endothelial cell Cd8-positive, alpha-beta t cell Iga plasma cell Igg plasma cell Epithelial cell of proximal tubule segment 1 Renal alpha-intercalated cell Macrophage Kidney distal convoluted tubule epithelial cell Kidney pelvis urothelial cell Kidney collecting duct principal cell Kidney connecting tubule principal cell Kidney loop of henle thick ascending limb epithelial cell Naive thymus-derived cd4-positive, alpha-beta t cell Collagen secreting cell Kidney loop of henle ascending limb epithelial cell Fibroblast

Kidney

Sixth decade stage

Nonpapillary renal cell carcinoma

Male

Visium spatial gene expression v1

Homo sapiens

Transit amplifying cell of small intestine Intestine goblet cell Natural killer cell Intestinal crypt stem cell of large intestine Secretory cell Neuroendocrine cell Interstitial cell of cajal Erythroid lineage cell Leukocyte Gut absorptive cell Inhibitory motor neuron Plasmacytoid dendritic cell Neural cell Enteroendocrine cell Gut endothelial cell Group 3 innate lymphoid cell Transit amplifying cell of colon Macrophage Enteric smooth muscle cell Glial cell Enterocyte Motor neuron B cell Pericyte Progenitor cell Naive t cell Intestinal crypt stem cell of small intestine Myofibroblast cell Fibroblast Dendritic cell

Colon

66-year-old stage

Normal

Male

Visium spatial gene expression v1

Homo sapiens

Transit amplifying cell of small intestine Intestine goblet cell Intestinal crypt stem cell of large intestine Secretory cell Neuroendocrine cell Interstitial cell of cajal Erythroid lineage cell Leukocyte Gut absorptive cell Inhibitory motor neuron Precursor b cell Enteroendocrine cell Gut endothelial cell Transit amplifying cell of colon Macrophage Enteric smooth muscle cell Enterocyte Motor neuron Interneuron Pericyte Progenitor cell Intestinal crypt stem cell of small intestine Monocyte Myofibroblast cell Fibroblast

Colon

20th week post-fertilization stage

Normal

Female

Visium spatial gene expression v1

Homo sapiens

Transit amplifying cell of small intestine Intestine goblet cell Intestinal crypt stem cell of large intestine Secretory cell Neuroendocrine cell Interstitial cell of cajal Leukocyte Inhibitory motor neuron Gut endothelial cell Transit amplifying cell of colon Macrophage Enteric smooth muscle cell Enterocyte Interneuron Pericyte Progenitor cell Intestinal crypt stem cell of small intestine Myofibroblast cell Fibroblast Dendritic cell

Ileum

13th week post-fertilization stage

Normal

Male

Visium spatial gene expression v1

Homo sapiens

Transit amplifying cell of small intestine Intestine goblet cell Intestinal crypt stem cell of large intestine Interstitial cell of cajal Gut absorptive cell Inhibitory motor neuron Enteroendocrine cell Gut endothelial cell Transit amplifying cell of colon Enteric smooth muscle cell Glial cell Enterocyte Interneuron Mesothelial cell Pericyte Progenitor cell Intestinal crypt stem cell of small intestine Myofibroblast cell Fibroblast

Colon

13th week post-fertilization stage

Normal

Male

Visium spatial gene expression v1