Homo sapiens

Periportal region hepatocyte Hepatocyte Centrilobular region hepatocyte Endothelial cell B cell Blood cell

Caudate lobe of liver

Prime adult stage

Normal

Male

Visium spatial gene expression v1

Homo sapiens

Periportal region hepatocyte Hepatocyte Centrilobular region hepatocyte Intrahepatic cholangiocyte

Caudate lobe of liver

Prime adult stage

Primary sclerosing cholangitis

Female

Visium spatial gene expression v1

Homo sapiens

Periportal region hepatocyte Hepatocyte Centrilobular region hepatocyte Blood cell Intrahepatic cholangiocyte

Caudate lobe of liver

Prime adult stage

Primary sclerosing cholangitis

Female

Visium spatial gene expression v1

Homo sapiens

Periportal region hepatocyte Hepatocyte Centrilobular region hepatocyte Endothelial cell B cell Blood cell

Caudate lobe of liver

Prime adult stage

Normal

Male

Visium spatial gene expression v1

Homo sapiens

Periportal region hepatocyte Centrilobular region hepatocyte Endothelial cell B cell Blood cell

Caudate lobe of liver

Prime adult stage

Normal

Male

Visium spatial gene expression v1

Homo sapiens

Endothelial tip cell Stromal cell Gamma-delta t cell Endothelial cell Mast cell Cd8-positive, alpha-beta t cell Inflammatory macrophage Smooth muscle cell Enteroglial cell Goblet cell Transit amplifying cell of colon Macrophage Regulatory t cell Endothelial stalk cell Enterocyte Cd4-positive, alpha-beta t cell Malignant cell T follicular helper cell B cell Pericyte Myofibroblast cell Conventional dendritic cell

Caecum

Ninth decade stage

Colorectal cancer

Male

Visium spatial gene expression v1

Homo sapiens

Stromal cell Iga plasma cell Inflammatory macrophage Smooth muscle cell Igg plasma cell Goblet cell Transit amplifying cell of colon Macrophage Endothelial stalk cell Enterocyte Malignant cell B cell Pericyte Myofibroblast cell

Right colon

Eighth decade stage

Colorectal cancer

Male

Visium spatial gene expression v1

Homo sapiens

Stromal cell Endothelial cell of lymphatic vessel Iga plasma cell Smooth muscle cell Igg plasma cell Goblet cell Transit amplifying cell of colon Macrophage Endothelial stalk cell Enterocyte Malignant cell B cell Pericyte Myofibroblast cell

Right colon

Eighth decade stage

Colorectal cancer

Male

Visium spatial gene expression v1

Homo sapiens

Endothelial tip cell Stromal cell Mast cell Cd8-positive, alpha-beta t cell Inflammatory macrophage Smooth muscle cell Enteroglial cell Igg plasma cell Goblet cell Transit amplifying cell of colon Macrophage Regulatory t cell Endothelial stalk cell Enterocyte Cd4-positive, alpha-beta t cell Malignant cell T follicular helper cell B cell Pericyte Myofibroblast cell Conventional dendritic cell

Rectosigmoid junction

Eighth decade stage

Colorectal cancer

Male

Visium spatial gene expression v1

Homo sapiens

Endothelial tip cell Cd8-positive, alpha-beta t cell Iga plasma cell Inflammatory macrophage Smooth muscle cell Igg plasma cell Goblet cell Transit amplifying cell of colon Macrophage Regulatory t cell Endothelial stalk cell Enterocyte Malignant cell B cell Pericyte

Rectum

Eighth decade stage

Colorectal cancer

Male

Visium spatial gene expression v1

Homo sapiens

Stromal cell Mast cell Cd8-positive, alpha-beta t cell Inflammatory macrophage Smooth muscle cell Enteroglial cell Igg plasma cell Macrophage Endothelial stalk cell Enterocyte Malignant cell Pericyte Myofibroblast cell

Sigmoid colon

Seventh decade stage

Colorectal cancer

Female

Visium spatial gene expression v1

Homo sapiens

Endothelial tip cell Endothelial cell Mast cell Cd8-positive, alpha-beta t cell Inflammatory macrophage Smooth muscle cell Macrophage Regulatory t cell Endothelial stalk cell Enterocyte Malignant cell B cell Pericyte Myofibroblast cell

Caecum

Ninth decade stage

Colorectal cancer

Male

Visium spatial gene expression v1