Homo sapiens

Motor neuron Progenitor cell Glial cell Neural cell Neuroendocrine cell Inhibitory motor neuron Interneuron

Hindgut Colon Ileum

10th week post-fertilization stage 14th week post-fertilization stage 16th week post-fertilization stage 11th week post-fertilization stage 21st week post-fertilization stage Carnegie stage 22 20th week post-fertilization stage 23rd week post-fertilization stage 19th week post-fertilization stage 13th week post-fertilization stage 18th week post-fertilization stage 17th week post-fertilization stage

Normal

Female Male

10x 3' v3

Cell

Microcebus murinus

Erythroid lineage cell B cell Endothelial cell of artery Pericyte Reticular cell Endothelial cell of lymphatic vessel Neutrophil Lymphocyte Mature nk t cell Cd4-positive, alpha-beta t cell Macrophage Cd8-positive, alpha-beta t cell Slow muscle cell Vascular associated smooth muscle cell Adipocyte Tendon cell Mesenchymal stem cell Capillary endothelial cell Fast muscle cell Basophil Vein endothelial cell Skeletal muscle satellite stem cell Plasma cell

Limb muscle

Post-juvenile adult stage

Normal

Female Male

10x 3' v2 Smart-seq2

Cell

Homo sapiens

B-1b b cell Precursor b cell Large pre-b-ii cell B-1a b cell Pro-b cell Small pre-b-ii cell Immature b cell Late pro-b cell Pre-b-i cell

Lung

9th week post-fertilization stage 11th week post-fertilization stage 15th week post-fertilization stage 20th week post-fertilization stage 18th week post-fertilization stage 22nd week post-fertilization stage

Normal

Female Male

10x 5' v1

Cell

Mus musculus

Notochordal cell Spinal cord interneuron Paraxial cell Neurectodermal cell Gut endothelial cell Splanchnic mesodermal cell Hemangioblast Cardiac valve cell Endodermal cell Primitive red blood cell Midbrain dopaminergic neuron Anterior visceral endoderm cell Premigratory neural crest cell Mesodermal cell Neuroplacodal cell Surface ectodermal cell

Embryo

Theiler stage 14

Normal

Slide-seqv2

Homo sapiens

Sncg gabaergic interneuron

Neocortex

Adult stage

Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Schwann cell Oligodendrocyte Oligodendrocyte precursor cell Committed oligodendrocyte precursor

Cerebellum Brain Hindbrain Midbrain Pons Telencephalon Diencephalon Medulla oblongata

10th week post-fertilization stage 9th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage Embryonic stage

Normal

Female Male

10x multiome

Nucleus

Homo sapiens

L5 extratelencephalic projecting glutamatergic cortical neuron

Dorsolateral prefrontal cortex

42-year-old stage 68-year-old stage 88-year-old stage 86-year-old stage 82-year-old stage 83-year-old stage 75-year-old stage 80-year-old stage 77-year-old stage 89-year-old stage 78-year-old stage 72-year-old stage 80 year-old and over stage 81-year-old stage 87-year-old stage 84-year-old stage 85-year-old stage 50-year-old stage 29-year-old stage 69-year-old stage 70-year-old stage

Dementia Normal

Female Male

10x multiome 10x 3' v3

Nucleus

Mus musculus

Epithelial cell of thymus Dn4 thymocyte Macrophage Endothelial cell Thymocyte Fibroblast

Thymus

20-month-old stage and over 18-month-old stage 3-month-old stage

Normal

Female Male

Smart-seq2

Cell

Homo sapiens

Effector t cell Natural killer cell T-helper 17 cell Central memory cd4-positive, alpha-beta t cell Effector memory cd8-positive, alpha-beta t cell Regulatory t cell B cell Cycling t cell Lymphocyte Mature nk t cell Effector memory cd4-positive, alpha-beta t cell Plasma cell Cytotoxic t cell

Heart left ventricle Apex of heart

38-year-old stage 32-year-old stage 31-year-old stage 49-year-old stage 21-year-old stage 30-year-old stage 19-year-old stage 64-year-old stage 25-year-old stage Seventh decade stage 24-year-old stage 55-year-old stage 28-year-old stage Fifth decade stage 61-year-old stage 26-year-old stage 27-year-old stage Sixth decade stage 52-year-old stage Eighth decade stage Third decade stage 29-year-old stage 70-year-old stage

Myocarditis Normal

Female Male

10x 3' v2 10x 3' v3

Nucleus

Mus musculus

Notochordal cell Spinal cord interneuron Paraxial cell Neurectodermal cell Gut endothelial cell Splanchnic mesodermal cell Hemangioblast Cardiac valve cell Endodermal cell Primitive red blood cell Midbrain dopaminergic neuron Anterior visceral endoderm cell Premigratory neural crest cell Mesodermal cell Neuroplacodal cell Surface ectodermal cell

Embryo

Theiler stage 14

Normal

Slide-seqv2

Homo sapiens

Kupffer cell Inflammatory macrophage

Caudate lobe of liver

Young adult stage Prime adult stage

Normal

Female Male

10x 3' v2 10x 3' v3

Cell Nucleus

Homo sapiens

Neural cell

Heart left ventricle Heart right ventricle Left cardiac atrium Interventricular septum Apex of heart Right cardiac atrium

Seventh decade stage Fifth decade stage Sixth decade stage Eighth decade stage

Normal

Female Male

10x 3' v2 10x 3' v3

Nucleus Cell