Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Pericyte Endothelial cell Neuron Central nervous system macrophage

Inferior frontal gyrus

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

L2/3 intratelencephalic projecting glutamatergic neuron Cerebral cortex gabaergic interneuron Cerebral cortex neuron Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Sst gabaergic interneuron L5/6 near-projecting glutamatergic neuron Microglial cell Endothelial cell L4 intratelencephalic projecting glutamatergic neuron Vip gabaergic interneuron Pvalb gabaergic interneuron

Medial orbital frontal cortex

82-year-old stage 66-year-old stage 79-year-old stage 77-year-old stage 57-year-old stage 60-year-old stage 78-year-old stage 63-year-old stage 58-year-old stage 68-year-old stage 90-year-old stage 69-year-old stage 55-year-old stage 83-year-old stage

Tongue cancer Small cell lung carcinoma Breast cancer Heart disorder Influenza Chronic obstructive pulmonary disease Cardiomyopathy Myocardial infarction Covid-19

Female Male

10x 3' v3

Nucleus

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Ependymal cell Pericyte Endothelial cell Neuron Central nervous system macrophage

Substantia innominata

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Pericyte Endothelial cell Neuron Central nervous system macrophage

Primary somatosensory cortex

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney connecting tubule epithelial cell Parietal epithelial cell Leukocyte Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Kidney loop of henle thin descending limb epithelial cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Pericyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Cortex of kidney

62-year-old stage

Normal

Male

Slide-seqv2

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Ependymal cell Pericyte Endothelial cell Neuron Central nervous system macrophage

Hippocampal field

42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Subcutaneous adipocyte Mural cell Endothelial cell of lymphatic vessel Macrophage Mast cell Endothelial cell B cell Dendritic cell T cell Mesenchymal stem cell of adipose tissue

Subcutaneous adipose tissue

33-year-old stage 34-year-old stage 24-year-old stage 41-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Igg plasma cell Iga plasma cell

Colorectum

91-year-old stage 82-year-old stage 70-year-old stage 77-year-old stage 50-year-old stage 57-year-old stage 76-year-old stage 62-year-old stage 52-year-old stage 60-year-old stage 48-year-old stage 64-year-old stage 89-year-old stage 45-year-old stage 67-year-old stage 71-year-old stage 78-year-old stage 36-year-old stage 59-year-old stage 47-year-old stage 56-year-old stage 58-year-old stage 61-year-old stage 51-year-old stage 49-year-old stage 42-year-old stage 35-year-old stage 53-year-old stage 72-year-old stage 73-year-old stage 90-year-old stage 69-year-old stage 81-year-old stage 55-year-old stage

Normal Colon adenocarcinoma

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Leukocyte Vascular associated smooth muscle cell Fibroblast Pericyte Endothelial cell Neuron Central nervous system macrophage

Brodmann (1909) area 25

50-year-old stage 42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Parietal epithelial cell Kidney distal convoluted tubule epithelial cell Renal beta-intercalated cell Renal principal cell Mononuclear leukocyte Epithelial cell of proximal tubule Fibroblast Podocyte Endothelial cell B cell Kidney proximal straight tubule epithelial cell T cell Kidney proximal convoluted tubule epithelial cell Renal alpha-intercalated cell Kidney loop of henle thin ascending limb epithelial cell

Cortex of kidney

57-year-old stage 52-year-old stage 74-year-old stage 78-year-old stage 59-year-old stage 61-year-old stage 51-year-old stage 53-year-old stage

Normal Type 2 diabetes mellitus

Female Male

10x scatac-seq

Nucleus

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney granular cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney interstitial fibroblast Kidney collecting duct principal cell Macula densa epithelial cell Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Podocyte Endothelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney outer medulla collecting duct intercalated cell Endothelial cell of lymphatic vessel Kidney connecting tubule epithelial cell Parietal epithelial cell Kidney connecting tubule principal cell Non-classical monocyte Endothelial cell of arteriole Lymphocyte Kidney collecting duct alpha-intercalated cell Renal interstitial pericyte Neutrophil Kidney interstitial alternatively activated macrophage Macula densa epithelial cell Vasa recta ascending limb cell Myeloid dendritic cell Renal beta-intercalated cell Renal principal cell Epithelial cell of proximal tubule Vascular associated smooth muscle cell Fibroblast Podocyte Glomerular capillary endothelial cell B cell Epithelial cell of early distal convoluted tubule Plasma cell Peritubular capillary endothelial cell Mesangial cell T cell Vasa recta descending limb cell Plasmacytoid dendritic cell Kidney proximal convoluted tubule epithelial cell Epithelial cell of proximal tubule segment 3

Cortex of kidney

50-year-old stage 57-year-old stage 74-year-old stage 67-year-old stage 59-year-old stage 68-year-old stage 53-year-old stage 72-year-old stage 69-year-old stage

Normal

Female Male

10x multiome

Nucleus