Homo sapiens

Endothelial cell of artery Lymphocyte Macrophage Blood vessel smooth muscle cell Microcirculation associated smooth muscle cell Fibroblast

Right coronary artery

46-year-old stage

Normal

Male

Slide-seqv2

Mus musculus

Gabaergic neuron Endothelial cell Glutamatergic neuron

Primary motor cortex

11-week-old stage 24-week-old stage 19-week-old stage 8-week-old stage 29-week-old stage 14-week-old stage 10-week-old stage 16-week-old stage 25-week-old stage 17-week-old stage 12-week-old stage 20-week-old stage 6-week-old stage Prime adult stage 9-week-old stage 18-week-old stage 7-week-old stage 15-week-old stage 22-week-old stage 13-week-old stage 26-week-old stage 5-week-old stage 23-week-old stage

Normal

Female Male

10x 3' v2 Patch-seq

Cell

Drosophila melanogaster

Enteroendocrine cell Copper cell Adult differentiating enterocyte Midgut large flat cell Enteroblast Muscle cell Epithelial cell Adult midgut enterocyte Intestinal stem cell Enterocyte of anterior adult midgut epithelium Enterocyte of posterior adult midgut epithelium Cardial cell Visceral muscle cell

Gut

Day 5 of adulthood

Normal

Female Male

10x 3' v3

Homo sapiens

Transit amplifying cell of small intestine Colon goblet cell Enterocyte of epithelium of large intestine Intestinal tuft cell Progenitor cell Tuft cell of colon Intestinal crypt stem cell of small intestine Enterocyte of epithelium of small intestine Small intestine goblet cell Microfold cell of epithelium of small intestine Enteroendocrine cell of small intestine Epithelial cell of small intestine Transit amplifying cell of colon Best4+ enterocyte Paneth cell of epithelium of small intestine Enteroendocrine cell of colon Intestinal crypt stem cell of colon

Ascending colon Descending colon Jejunum Duodenum Transverse colon Ileum

45-year-old stage 53-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Cell

Homo sapiens

Oligodendrocyte Natural killer cell Astrocyte T cell Medial ganglionic eminence derived interneuron Pvalb chandelier gabaergic interneuron Microglial cell Oligodendrocyte precursor cell Neuron Ependymal cell Pericyte Committed oligodendrocyte precursor Monocyte Eccentric medium spiny neuron Cerebral cortex neuron Intratelencephalic-projecting glutamatergic cortical neuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Hippocampal ca1-3 neuron Endothelial cell Amygdala excitatory neuron Caudal ganglionic eminence derived interneuron Medium spiny neuron Fibroblast Lamp5 lhx6 neuron Near-projecting glutamatergic cortical neuron

Supraoptic nucleus

50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Drosophila melanogaster

Male germline cell Crystal cell Neuron Tracheolar cell Embryonic/larval crystal cell Neuron Adult abdominal pericardial cell Muscle cell Fat cell Epithelial cell Female germline cell Hemocyte Sensory neuron Adult oenocyte Oenocyte Somatic precursor cell Indirect flight muscle cell Adult heart ventral longitudinal muscle cell Cardial cell Glial cell Adult tracheocyte

Heart

Day 5 of adulthood

Normal

Female Male

10x 3' v3

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial fibroblast Leukocyte Kidney proximal convoluted tubule epithelial cell Macula densa epithelial cell Podocyte Kidney collecting duct principal cell Macrophage Blood vessel smooth muscle cell Endothelial cell Kidney collecting duct intercalated cell Mesangial cell Kidney granular cell Kidney distal convoluted tubule epithelial cell

Kidney

6-month-old stage

Autosomal dominant polycystic kidney disease

Male

Slide-seqv2

Mus musculus

Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial fibroblast Leukocyte Kidney proximal convoluted tubule epithelial cell Macula densa epithelial cell Podocyte Kidney collecting duct principal cell Macrophage Blood vessel smooth muscle cell Endothelial cell Kidney collecting duct intercalated cell Mesangial cell Kidney granular cell Kidney distal convoluted tubule epithelial cell

Kidney

6-month-old stage

Autosomal dominant polycystic kidney disease

Male

Slide-seqv2

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial fibroblast Leukocyte Kidney proximal convoluted tubule epithelial cell Podocyte Parietal epithelial cell Pericyte Kidney collecting duct principal cell Blood vessel smooth muscle cell Kidney loop of henle thin descending limb epithelial cell Endothelial cell Kidney loop of henle epithelial cell Kidney collecting duct intercalated cell Mesangial cell Kidney connecting tubule epithelial cell Kidney distal convoluted tubule epithelial cell

Renal medulla

64-year-old stage

Normal

Female

Slide-seqv2

Homo sapiens

Naive b cell Iga plasma cell Class switched memory b cell Igg plasma cell Unswitched memory b cell

Breast

Adult stage Prime adult stage

Normal

Female

10x 3' v2 10x 3' v3

Cell

Homo sapiens

Hepatocyte T cell B cell Monocyte Malignant cell Mature nk t cell Macrophage Endothelial cell Fibroblast Plasma cell

Liver

40-year-old stage

Breast cancer

Female

10x 3' v3

Cell

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney interstitial fibroblast Leukocyte Kidney proximal convoluted tubule epithelial cell Macula densa epithelial cell Podocyte Kidney collecting duct principal cell Macrophage Blood vessel smooth muscle cell Endothelial cell Kidney collecting duct intercalated cell Mesangial cell Kidney granular cell Kidney distal convoluted tubule epithelial cell

Cortex of kidney

64-year-old stage

Normal

Female

Slide-seqv2