Mus musculus

Perineuronal satellite cell Oligodendrocyte precursor cell Monocyte Respiratory tract goblet cell Neuron Gabaergic neuron Pulmonary alveolar type 1 cell Endothelial cell of artery B cell Pinealocyte Conventional dendritic cell Leydig cell Cardiac muscle cell Peripheral nervous system neuron Amacrine cell Kidney loop of henle ascending limb epithelial cell Endocardial cell Retinal progenitor cell Osteoblast Hematopoietic stem cell Fibroblast Kidney epithelial cell Sympathetic neuron Small bistratified retinal ganglion cell Conjunctiva goblet cell Bladder urothelial cell Activated cd4-negative, cd8-negative type i nk t cell Cranial motor neuron Club cell Intrahepatic cholangiocyte Lateral mesodermal cell Auditory epithelial cell Olfactory ensheathing cell Brain pericyte Pericyte Retinal bipolar neuron Chondrocyte Endothelial cell of hepatic sinusoid Regulatory t cell Epithelial cell of pancreas Primordial germ cell Granulocyte Intestine goblet cell Pituitary gland cell Endothelial cell of lymphatic vessel Olfactory epithelial cell Endothelial cell Retinal ganglion cell Epithelial cell of thyroid gland Olfactory receptor cell Ureteric bud cell Committed oligodendrocyte precursor Epithelial cell of thymus Natural killer cell Choroid plexus epithelial cell Keratinocyte Iris pigment epithelial cell Podocyte Hypothalamus cell Kidney connecting tubule epithelial cell Cajal-retzius cell Cochlea auditory hair cell Type i cell of adrenal cortex Embryonic blood vessel endothelial progenitor cell Photoreceptor cell Metanephric mesenchyme stem cell Gingival epithelial cell Epithelial cell of proximal tubule Myotube Adipocyte Glomerular endothelial cell Extraembryonic cell Schwann cell precursor Retinal cone cell Melanocyte Epithelial cell of amnion Kidney collecting duct principal cell Brown preadipocyte Retinal rod cell Epithelial cell Retinal pigment epithelial cell Spinal cord motor neuron Hepatocyte Myofibroblast cell Enteric neuron Cerebral cortex gabaergic interneuron Starburst amacrine cell Microglial cell Lens epithelial cell Lung endothelial cell Corneal epithelial cell Epithelial cell of parathyroid gland Myoblast Microvascular endothelial cell Intermediate mesodermal cell Efferent neuron Neural progenitor cell Endo-epithelial cell Cerebral cortex endothelial cell Osteoclast Central nervous system macrophage Splanchnic mesodermal cell Erythroid progenitor cell Kidney collecting duct intercalated cell Neural cell Brown adipocyte Plasmacytoid dendritic cell Glutamatergic neuron Retina horizontal cell Ciliated cell Notochordal cell Mesodermal cell Muscle precursor cell Parasympathetic neuron Myeloid suppressor cell T cell Spiral ganglion neuron Pancreatic acinar cell Purkinje cell Kupffer cell Mast cell Thalamic excitatory neuron Astrocyte Ependymal cell Vein endothelial cell Adipose macrophage Primitive erythroid progenitor Myelinating schwann cell Sensory neuron of dorsal root ganglion Pulmonary alveolar type 2 cell Intestinal enteroendocrine cell Kidney distal convoluted tubule epithelial cell Ectodermal cell Megakaryocyte

Embryo

Theiler stage 22 Theiler stage 20 Theiler stage 14 Theiler stage 12 Theiler stage 24 Theiler stage 27 Theiler stage 17 Theiler stage 19 Theiler stage 15 Theiler stage 26 Theiler stage 21 Theiler stage 23 Theiler stage 13 Theiler stage 16 Theiler stage 25 Theiler stage 18

Normal

Male Female

Sci-rna-seq3

Nucleus

Mus musculus

Oligodendrocyte precursor cell Monocyte Macrophage Gabaergic neuron Neuroblast (sensu vertebrata) Olfactory ensheathing cell Hypendymal cell Pericyte Endothelial cell Vascular leptomeningeal cell Dopaminergic neuron Choroid plexus epithelial cell Smooth muscle cell Cholinergic neuron Dendritic cell Microglial cell Oligodendrocyte Glycinergic neuron Glutamatergic neuron Bergmann glial cell Tanycyte Astrocyte Ependymal cell Histaminergic neuron Lymphocyte

Pallidum Hindbrain Cerebellum Cortical subplate Thalamic complex Brain Hypothalamus Ventricular system of brain White matter Striatum Midbrain Hippocampal formation Neocortex

9-week-old stage

Normal

Female

Merfish

Homo sapiens

Oligodendrocyte precursor cell Gabaergic neuron B cell Vip gabaergic interneuron L6 intratelencephalic projecting glutamatergic neuron Sst gabaergic interneuron Pericyte Endothelial cell L6 corticothalamic-projecting glutamatergic cortical neuron Vascular leptomeningeal cell Perivascular macrophage Natural killer cell Smooth muscle cell L5 extratelencephalic projecting glutamatergic cortical neuron L2/3-6 intratelencephalic projecting glutamatergic neuron Microglial cell Oligodendrocyte L5/6 near-projecting glutamatergic neuron Plasma cell L6b glutamatergic neuron of the primary motor cortex Lamp5 gabaergic interneuron Pvalb gabaergic interneuron T cell Astrocyte L2/3 intratelencephalic projecting glutamatergic neuron

Dorsolateral prefrontal cortex

69-year-old stage 56-year-old stage 83-year-old stage 77-year-old stage 80 year-old and over stage 81-year-old stage 47-year-old stage 87-year-old stage 25-year-old stage 64-year-old stage 79-year-old stage 50-year-old stage 36-year-old stage 38-year-old stage 66-year-old stage 68-year-old stage 40-year-old stage 49-year-old stage 82-year-old stage 78-year-old stage 67-year-old stage 89-year-old stage 63-year-old stage 86-year-old stage 48-year-old stage 31-year-old stage 19-year-old stage 20-year-old stage 54-year-old stage 28-year-old stage 80-year-old stage 65-year-old stage 58-year-old stage 32-year-old stage 42-year-old stage 71-year-old stage 60-year-old stage 39-year-old stage 76-year-old stage 41-year-old stage 51-year-old stage 45-year-old stage 85-year-old stage 61-year-old stage 74-year-old stage 62-year-old stage 75-year-old stage 72-year-old stage 43-year-old stage 59-year-old stage 57-year-old stage 27-year-old stage 46-year-old stage 35-year-old stage 73-year-old stage 88-year-old stage 24-year-old stage 52-year-old stage 55-year-old stage 53-year-old stage 70-year-old stage 84-year-old stage

Vascular dementia Major depressive disorder Normal pressure hydrocephalus Multiple sclerosis Lewy body dementia Parkinson disease Normal Brain neoplasm Frontotemporal dementia Post-traumatic stress disorder Tauopathy Schizophrenia Head injury Alzheimer disease Amyotrophic lateral sclerosis Dementia Progressive supranuclear palsy

Male Female

10x 3' v3

Nucleus

Homo sapiens

Neuron Gabaergic neuron Taste receptor cell Inhibitory interneuron Epithelial cell of lower respiratory tract Cardiac muscle cell Amacrine cell Endocardial cell Hematopoietic stem cell Glial cell Sympathetic neuron Chorionic trophoblast cell Cell of skeletal muscle Innate lymphoid cell Hepatic stellate cell Ganglion interneuron Stromal cell Bipolar neuron Blood vessel endothelial cell Goblet cell Pancreatic ductal cell Endocrine cell Myeloid cell Endothelial cell of lymphatic vessel Stellate neuron Retinal ganglion cell Unipolar brush cell Schwann cell Epithelial cell of thymus Smooth muscle cell Regular atrial cardiac myocyte Hepatoblast Photoreceptor cell Ciliated epithelial cell Chromaffin cell Acinar cell Ventricular cardiac muscle cell Professional antigen presenting cell Macroglial cell Intestinal epithelial cell Mueller cell Syncytiotrophoblast cell Thymocyte Retinal pigment epithelial cell Neuroendocrine cell Squamous epithelial cell Trophoblast giant cell Enteric neuron Microglial cell Epicardial adipocyte Corneal epithelial cell Lens fiber cell Oligodendrocyte Granule cell Mesothelial cell Extravillous trophoblast Visceromotor neuron Glutamatergic neuron Retina horizontal cell Skeletal muscle satellite cell Cortical cell of adrenal gland Hematopoietic cell Neuron associated cell (sensu vertebrata) Erythroblast Purkinje cell Dermis microvascular lymphatic vessel endothelial cell Astrocyte Mesangial cell Tuft cell Endothelial cell of vascular tree Megakaryocyte

Liver Heart Cerebellum Pancreas Muscle organ Kidney Intestine Placenta Adrenal gland Stomach Lung Eye Telencephalon Spleen Thymus

10th week post-fertilization stage 12th week post-fertilization stage 15th week post-fertilization stage 14th week post-fertilization stage 18th week post-fertilization stage 17th week post-fertilization stage 16th week post-fertilization stage 13th week post-fertilization stage

Normal Trisomy 18

Male Female

Sci-rna-seq3

Nucleus Cell

Mus musculus

Osteoblast Fibroblast Lateral mesodermal cell Chondrocyte Mesodermal cell

Embryo

Theiler stage 22 Theiler stage 20 Theiler stage 14 Theiler stage 12 Theiler stage 24 Theiler stage 27 Theiler stage 17 Theiler stage 19 Theiler stage 15 Theiler stage 26 Theiler stage 21 Theiler stage 23 Theiler stage 13 Theiler stage 16 Theiler stage 25 Theiler stage 18

Normal

Male Female

Sci-rna-seq3

Nucleus

Homo sapiens

Diffuse bipolar 1 cell Giant bipolar cell Amacrine cell Flat midget bipolar cell Off midget ganglion cell Retinal bipolar neuron On midget ganglion cell Invaginating midget bipolar cell Diffuse bipolar 4 cell Retinal ganglion cell Diffuse bipolar 3a cell H1 horizontal cell Rod bipolar cell Diffuse bipolar 2 cell H2 horizontal cell Offx cell Retinal cone cell Mueller cell Retinal rod cell Retinal pigment epithelial cell Starburst amacrine cell Microglial cell S cone cell Off parasol ganglion cell On-blue cone bipolar cell Gabaergic amacrine cell Glycinergic amacrine cell Diffuse bipolar 6 cell Astrocyte Diffuse bipolar 3b cell On parasol ganglion cell

Normal

10x 3' v3

Homo sapiens

Diffuse bipolar 1 cell Giant bipolar cell Amacrine cell Flat midget bipolar cell Off midget ganglion cell Retinal bipolar neuron On midget ganglion cell Invaginating midget bipolar cell Diffuse bipolar 4 cell Retinal ganglion cell Diffuse bipolar 3a cell H1 horizontal cell Rod bipolar cell Diffuse bipolar 2 cell H2 horizontal cell Offx cell Retinal cone cell Mueller cell Retinal rod cell Retinal pigment epithelial cell Starburst amacrine cell Microglial cell S cone cell Off parasol ganglion cell On-blue cone bipolar cell Gabaergic amacrine cell Glycinergic amacrine cell Diffuse bipolar 6 cell Astrocyte Diffuse bipolar 3b cell On parasol ganglion cell

Peripheral region of retina Macula lutea proper Macula lutea Fovea centralis

69-year-old stage 83-year-old stage 77-year-old stage 80 year-old and over stage 81-year-old stage 47-year-old stage 60-79 year-old stage 25-year-old stage 90 year-old and over stage 64-year-old stage 10-year-old stage 50-year-old stage 18-year-old stage 66-year-old stage 68-year-old stage Eighth decade stage 82-year-old stage 78-year-old stage 67-year-old stage Late adult stage 63-year-old stage 86-year-old stage 21-year-old stage 80-year-old stage 65-year-old stage 58-year-old stage 32-year-old stage 11-year-old stage 30-year-old stage 71-year-old stage 60-year-old stage 76-year-old stage 41-year-old stage 34-year-old stage 85-year-old stage 16-year-old stage 74-year-old stage 62-year-old stage 75-year-old stage 72-year-old stage 15-year-old stage 43-year-old stage 27-year-old stage 46-year-old stage 17-year-old stage 73-year-old stage Prime adult stage 88-year-old stage 24-year-old stage 52-year-old stage 53-year-old stage 70-year-old stage 3-year-old stage 84-year-old stage

Normal

Male Female

10x 3' v3

Nucleus

Mus musculus

Perineuronal satellite cell Duct epithelial cell Oligodendrocyte precursor cell Monocyte Respiratory tract goblet cell Neuron Gabaergic neuron Pulmonary alveolar type 1 cell Endothelial cell of artery B cell Pinealocyte Conventional dendritic cell Leydig cell Cardiac muscle cell Peripheral nervous system neuron Amacrine cell Kidney loop of henle ascending limb epithelial cell Endocardial cell Retinal progenitor cell Osteoblast Hematopoietic stem cell Fibroblast Kidney epithelial cell Sympathetic neuron Conjunctiva goblet cell Bladder urothelial cell Activated cd4-negative, cd8-negative type i nk t cell Cranial motor neuron Club cell Intrahepatic cholangiocyte Lateral mesodermal cell Auditory epithelial cell Olfactory ensheathing cell Brain pericyte Pericyte Retinal bipolar neuron Chondrocyte Endothelial cell of hepatic sinusoid Regulatory t cell Epithelial cell of pancreas Primordial germ cell Granulocyte Intestine goblet cell Pituitary gland cell Endothelial cell of lymphatic vessel Olfactory epithelial cell Endothelial cell Retinal ganglion cell Epithelial cell of thyroid gland Olfactory receptor cell Committed oligodendrocyte precursor Epithelial cell of thymus Natural killer cell Choroid plexus epithelial cell Keratinocyte Iris pigment epithelial cell Podocyte Hypothalamus cell Kidney connecting tubule epithelial cell Cajal-retzius cell Cochlea auditory hair cell Type i cell of adrenal cortex Embryonic blood vessel endothelial progenitor cell Photoreceptor cell Metanephric mesenchyme stem cell Gingival epithelial cell Epithelial cell of proximal tubule Myotube Adipocyte Glomerular endothelial cell Extraembryonic cell Schwann cell precursor Retinal cone cell Melanocyte Epithelial cell of amnion Kidney collecting duct principal cell Brown preadipocyte Retinal rod cell Epithelial cell Retinal pigment epithelial cell Spinal cord motor neuron Hepatocyte Myofibroblast cell Enteric neuron Cerebral cortex gabaergic interneuron Starburst amacrine cell Microglial cell Lens epithelial cell Lung endothelial cell Corneal epithelial cell Epithelial cell of parathyroid gland Myoblast Microvascular endothelial cell Intermediate mesodermal cell Efferent neuron Neural progenitor cell Endo-epithelial cell Cerebral cortex endothelial cell Osteoclast Central nervous system macrophage Splanchnic mesodermal cell Erythroid progenitor cell Kidney collecting duct intercalated cell Neural cell Brown adipocyte Plasmacytoid dendritic cell Glutamatergic neuron Retina horizontal cell Ciliated cell Notochordal cell Mesodermal cell Muscle precursor cell Parasympathetic neuron Myeloid suppressor cell T cell Spiral ganglion neuron Pancreatic acinar cell Purkinje cell Kupffer cell Mast cell Thalamic excitatory neuron Astrocyte Ependymal cell Vein endothelial cell Adipose macrophage Primitive erythroid progenitor Myelinating schwann cell Sensory neuron of dorsal root ganglion Pulmonary alveolar type 2 cell Intestinal enteroendocrine cell Kidney distal convoluted tubule epithelial cell Bistratified retinal ganglion cell Ectodermal cell Megakaryocyte

Embryo

Theiler stage 22 Theiler stage 20 Theiler stage 14 Theiler stage 12 Theiler stage 24 Theiler stage 27 Theiler stage 17 Theiler stage 19 Theiler stage 15 Theiler stage 26 Theiler stage 21 Theiler stage 23 Theiler stage 13 Theiler stage 16 Theiler stage 25 Theiler stage 18

Normal

Male Female

Sci-rna-seq3

Nucleus

Mus musculus

Perineuronal satellite cell Duct epithelial cell Oligodendrocyte precursor cell Monocyte Respiratory tract goblet cell Neuron Gabaergic neuron Pulmonary alveolar type 1 cell Endothelial cell of artery B cell Pinealocyte Conventional dendritic cell Leydig cell Cardiac muscle cell Peripheral nervous system neuron Amacrine cell Kidney loop of henle ascending limb epithelial cell Endocardial cell Retinal progenitor cell Osteoblast Hematopoietic stem cell Fibroblast Kidney epithelial cell Sympathetic neuron Conjunctiva goblet cell Bladder urothelial cell Activated cd4-negative, cd8-negative type i nk t cell Cranial motor neuron Club cell Intrahepatic cholangiocyte Lateral mesodermal cell Auditory epithelial cell Olfactory ensheathing cell Brain pericyte Pericyte Retinal bipolar neuron Chondrocyte Endothelial cell of hepatic sinusoid Regulatory t cell Epithelial cell of pancreas Primordial germ cell Granulocyte Intestine goblet cell Pituitary gland cell Endothelial cell of lymphatic vessel Olfactory epithelial cell Endothelial cell Retinal ganglion cell Epithelial cell of thyroid gland Olfactory receptor cell Committed oligodendrocyte precursor Epithelial cell of thymus Natural killer cell Choroid plexus epithelial cell Keratinocyte Iris pigment epithelial cell Podocyte Hypothalamus cell Kidney connecting tubule epithelial cell Cajal-retzius cell Cochlea auditory hair cell Type i cell of adrenal cortex Embryonic blood vessel endothelial progenitor cell Photoreceptor cell Metanephric mesenchyme stem cell Gingival epithelial cell Epithelial cell of proximal tubule Myotube Adipocyte Glomerular endothelial cell Extraembryonic cell Schwann cell precursor Retinal cone cell Melanocyte Epithelial cell of amnion Kidney collecting duct principal cell Brown preadipocyte Retinal rod cell Epithelial cell Retinal pigment epithelial cell Spinal cord motor neuron Hepatocyte Myofibroblast cell Enteric neuron Cerebral cortex gabaergic interneuron Starburst amacrine cell Microglial cell Lens epithelial cell Lung endothelial cell Corneal epithelial cell Epithelial cell of parathyroid gland Myoblast Microvascular endothelial cell Intermediate mesodermal cell Efferent neuron Neural progenitor cell Endo-epithelial cell Cerebral cortex endothelial cell Osteoclast Central nervous system macrophage Splanchnic mesodermal cell Erythroid progenitor cell Kidney collecting duct intercalated cell Neural cell Brown adipocyte Plasmacytoid dendritic cell Glutamatergic neuron Retina horizontal cell Ciliated cell Notochordal cell Mesodermal cell Muscle precursor cell Parasympathetic neuron Myeloid suppressor cell T cell Spiral ganglion neuron Pancreatic acinar cell Purkinje cell Kupffer cell Mast cell Thalamic excitatory neuron Astrocyte Ependymal cell Vein endothelial cell Adipose macrophage Primitive erythroid progenitor Myelinating schwann cell Sensory neuron of dorsal root ganglion Pulmonary alveolar type 2 cell Intestinal enteroendocrine cell Kidney distal convoluted tubule epithelial cell Bistratified retinal ganglion cell Ectodermal cell Megakaryocyte

Embryo

Theiler stage 22 Theiler stage 20 Theiler stage 14 Theiler stage 12 Theiler stage 24 Theiler stage 27 Theiler stage 17 Theiler stage 19 Theiler stage 15 Theiler stage 26 Theiler stage 21 Theiler stage 23 Theiler stage 13 Theiler stage 16 Theiler stage 25 Theiler stage 18

Normal

Male Female

Sci-rna-seq3

Nucleus

Mus musculus

Perineuronal satellite cell Duct epithelial cell Oligodendrocyte precursor cell Monocyte Respiratory tract goblet cell Neuron Gabaergic neuron Pulmonary alveolar type 1 cell Endothelial cell of artery B cell Pinealocyte Conventional dendritic cell Leydig cell Cardiac muscle cell Peripheral nervous system neuron Amacrine cell Kidney loop of henle ascending limb epithelial cell Endocardial cell Retinal progenitor cell Osteoblast Hematopoietic stem cell Fibroblast Kidney epithelial cell Sympathetic neuron Conjunctiva goblet cell Bladder urothelial cell Activated cd4-negative, cd8-negative type i nk t cell Cranial motor neuron Club cell Intrahepatic cholangiocyte Lateral mesodermal cell Auditory epithelial cell Olfactory ensheathing cell Brain pericyte Pericyte Retinal bipolar neuron Chondrocyte Endothelial cell of hepatic sinusoid Regulatory t cell Epithelial cell of pancreas Primordial germ cell Granulocyte Intestine goblet cell Pituitary gland cell Endothelial cell of lymphatic vessel Olfactory epithelial cell Endothelial cell Retinal ganglion cell Epithelial cell of thyroid gland Olfactory receptor cell Committed oligodendrocyte precursor Epithelial cell of thymus Natural killer cell Choroid plexus epithelial cell Keratinocyte Iris pigment epithelial cell Podocyte Hypothalamus cell Kidney connecting tubule epithelial cell Cajal-retzius cell Cochlea auditory hair cell Type i cell of adrenal cortex Embryonic blood vessel endothelial progenitor cell Photoreceptor cell Metanephric mesenchyme stem cell Gingival epithelial cell Epithelial cell of proximal tubule Myotube Adipocyte Glomerular endothelial cell Extraembryonic cell Schwann cell precursor Retinal cone cell Melanocyte Epithelial cell of amnion Kidney collecting duct principal cell Brown preadipocyte Retinal rod cell Epithelial cell Retinal pigment epithelial cell Spinal cord motor neuron Hepatocyte Myofibroblast cell Enteric neuron Cerebral cortex gabaergic interneuron Starburst amacrine cell Microglial cell Lens epithelial cell Lung endothelial cell Corneal epithelial cell Epithelial cell of parathyroid gland Myoblast Microvascular endothelial cell Intermediate mesodermal cell Efferent neuron Neural progenitor cell Endo-epithelial cell Cerebral cortex endothelial cell Osteoclast Central nervous system macrophage Splanchnic mesodermal cell Erythroid progenitor cell Kidney collecting duct intercalated cell Neural cell Brown adipocyte Plasmacytoid dendritic cell Glutamatergic neuron Retina horizontal cell Ciliated cell Notochordal cell Mesodermal cell Muscle precursor cell Parasympathetic neuron Myeloid suppressor cell T cell Spiral ganglion neuron Pancreatic acinar cell Purkinje cell Kupffer cell Mast cell Thalamic excitatory neuron Astrocyte Ependymal cell Vein endothelial cell Adipose macrophage Primitive erythroid progenitor Myelinating schwann cell Sensory neuron of dorsal root ganglion Pulmonary alveolar type 2 cell Intestinal enteroendocrine cell Kidney distal convoluted tubule epithelial cell Bistratified retinal ganglion cell Ectodermal cell Megakaryocyte

Embryo

Theiler stage 22 Theiler stage 20 Theiler stage 14 Theiler stage 12 Theiler stage 24 Theiler stage 27 Theiler stage 17 Theiler stage 19 Theiler stage 15 Theiler stage 26 Theiler stage 21 Theiler stage 23 Theiler stage 13 Theiler stage 16 Theiler stage 25 Theiler stage 18

Normal

Male Female

Sci-rna-seq3

Nucleus

Mus musculus

Perineuronal satellite cell Duct epithelial cell Oligodendrocyte precursor cell Monocyte Respiratory tract goblet cell Neuron Gabaergic neuron Pulmonary alveolar type 1 cell Endothelial cell of artery B cell Pinealocyte Conventional dendritic cell Leydig cell Cardiac muscle cell Peripheral nervous system neuron Amacrine cell Kidney loop of henle ascending limb epithelial cell Endocardial cell Retinal progenitor cell Osteoblast Hematopoietic stem cell Fibroblast Kidney epithelial cell Sympathetic neuron Conjunctiva goblet cell Bladder urothelial cell Activated cd4-negative, cd8-negative type i nk t cell Cranial motor neuron Club cell Intrahepatic cholangiocyte Lateral mesodermal cell Auditory epithelial cell Olfactory ensheathing cell Brain pericyte Pericyte Retinal bipolar neuron Chondrocyte Endothelial cell of hepatic sinusoid Regulatory t cell Epithelial cell of pancreas Primordial germ cell Granulocyte Intestine goblet cell Pituitary gland cell Endothelial cell of lymphatic vessel Olfactory epithelial cell Endothelial cell Retinal ganglion cell Epithelial cell of thyroid gland Olfactory receptor cell Committed oligodendrocyte precursor Epithelial cell of thymus Natural killer cell Choroid plexus epithelial cell Keratinocyte Iris pigment epithelial cell Podocyte Hypothalamus cell Kidney connecting tubule epithelial cell Cajal-retzius cell Cochlea auditory hair cell Type i cell of adrenal cortex Embryonic blood vessel endothelial progenitor cell Photoreceptor cell Metanephric mesenchyme stem cell Gingival epithelial cell Epithelial cell of proximal tubule Myotube Adipocyte Glomerular endothelial cell Extraembryonic cell Schwann cell precursor Retinal cone cell Melanocyte Epithelial cell of amnion Kidney collecting duct principal cell Brown preadipocyte Retinal rod cell Epithelial cell Retinal pigment epithelial cell Spinal cord motor neuron Hepatocyte Myofibroblast cell Enteric neuron Cerebral cortex gabaergic interneuron Starburst amacrine cell Microglial cell Lens epithelial cell Lung endothelial cell Corneal epithelial cell Epithelial cell of parathyroid gland Myoblast Microvascular endothelial cell Intermediate mesodermal cell Efferent neuron Neural progenitor cell Endo-epithelial cell Cerebral cortex endothelial cell Osteoclast Central nervous system macrophage Splanchnic mesodermal cell Erythroid progenitor cell Kidney collecting duct intercalated cell Neural cell Brown adipocyte Plasmacytoid dendritic cell Glutamatergic neuron Retina horizontal cell Ciliated cell Notochordal cell Mesodermal cell Muscle precursor cell Parasympathetic neuron Myeloid suppressor cell T cell Spiral ganglion neuron Pancreatic acinar cell Purkinje cell Kupffer cell Mast cell Thalamic excitatory neuron Astrocyte Ependymal cell Vein endothelial cell Adipose macrophage Primitive erythroid progenitor Myelinating schwann cell Sensory neuron of dorsal root ganglion Pulmonary alveolar type 2 cell Intestinal enteroendocrine cell Kidney distal convoluted tubule epithelial cell Bistratified retinal ganglion cell Ectodermal cell Megakaryocyte

Embryo

Theiler stage 22 Theiler stage 20 Theiler stage 14 Theiler stage 12 Theiler stage 24 Theiler stage 27 Theiler stage 17 Theiler stage 19 Theiler stage 15 Theiler stage 26 Theiler stage 21 Theiler stage 23 Theiler stage 13 Theiler stage 16 Theiler stage 25 Theiler stage 18

Normal

Male Female

Sci-rna-seq3

Nucleus

Homo sapiens

Cd14-positive, cd16-negative classical monocyte Memory b cell Naive b cell Innate lymphoid cell Naive thymus-derived cd4-positive, alpha-beta t cell Common myeloid progenitor Erythrocyte Memory regulatory t cell Cd16-positive, cd56-dim natural killer cell, human Natural killer cell Common lymphoid progenitor Double negative thymocyte Naive regulatory t cell Effector memory cd4-positive, alpha-beta t cell Cd4-positive, alpha-beta memory t cell Cd8-positive, alpha-beta memory t cell Central memory cd4-positive, alpha-beta t cell Effector memory cd8-positive, alpha-beta t cell Mucosal invariant t cell Basophil mast progenitor cell Naive thymus-derived cd8-positive, alpha-beta t cell Central memory cd8-positive, alpha-beta t cell Cd8aa(i) thymocyte Plasma cell Cd8-positive, alpha-beta regulatory t cell Plasmacytoid dendritic cell Cd1c-positive myeloid dendritic cell Mature gamma-delta t cell Transitional stage b cell Axl+ dendritic cell, human Cd14-low, cd16-positive monocyte Platelet Cd16-negative, cd56-bright natural killer cell, human Memory ccr4-positive regulatory t cell T cell Be cell Intermediate monocyte Cd141-positive myeloid dendritic cell

Blood

25-year-old stage 36-year-old stage 31-year-old stage 28-year-old stage 32-year-old stage 30-year-old stage 34-year-old stage 26-year-old stage 33-year-old stage 29-year-old stage 27-year-old stage 35-year-old stage

Normal

Female

10x 3' v3

Cell