Homo sapiens

Macrophage Endothelial cell of artery Iga plasma cell Naive b cell Innate lymphoid cell Pericyte Gamma-delta t cell Regulatory t cell Hair follicular keratinocyte Endothelial cell of lymphatic vessel Cd8-positive, alpha-beta t cell Schwann cell Natural killer cell Keratinocyte Sweat secreting cell Smooth muscle cell Capillary endothelial cell Neutrophil Plasmablast Melanocyte Igg plasma cell Dendritic cell Skin fibroblast Sebaceous gland cell T cell Mast cell Vein endothelial cell

Normal Atopic eczema

10x 3' v3

Homo sapiens

Oligodendrocyte precursor cell Microglial cell Oligodendrocyte Neural cell Astrocyte

Medial ganglionic eminence Temporal cortex Caudal ganglionic eminence Insular cortex Cerebral cortex Frontal cortex Primary motor cortex Ganglionic eminence Lateral ganglionic eminence Cingulate cortex

3-month-old stage 5-month-old stage 8-year-old stage 22-year-old stage 25-year-old stage 5-year-old stage 1-year-old stage 10-year-old stage Seventh lmp month stage 6-year-old stage Newborn stage (0-28 days) 4-month-old stage 40-year-old stage Fourth lmp month stage 1-month-old stage Fifth lmp month stage 21-year-old stage 13-year-old stage 19-year-old stage 20-year-old stage 54-year-old stage 28-year-old stage 39-year-old stage 14-year-old stage 34-year-old stage Ninth lmp month stage 45-year-old stage 2-month-old stage 16-year-old stage 12-year-old stage 15-year-old stage 17-year-old stage 2-year-old stage Eighth lmp month stage Sixth lmp month stage 53-year-old stage 44-year-old stage 4-year-old stage Infant stage 3-year-old stage

Normal

Male Female

10x 3' v3 10x 3' v2 10x multiome

Nucleus

Homo sapiens

Fibroblast Regular ventricular cardiac myocyte Myeloid cell Endothelial cell of lymphatic vessel Endothelial cell Regular atrial cardiac myocyte Adipocyte Mural cell Mesothelial cell Neural cell Mast cell Lymphocyte

Left cardiac atrium Heart left ventricle Sinoatrial node Apex of heart Atrioventricular node Interventricular septum Right cardiac atrium Heart right ventricle

Eighth decade stage Fifth decade stage Sixth decade stage Seventh decade stage Third decade stage

Normal

Male Female

10x 3' v3 10x 3' v2 10x multiome

Cell Nucleus

Homo sapiens

Oligodendrocyte precursor cell Gabaergic neuron B cell Vip gabaergic interneuron L6 intratelencephalic projecting glutamatergic neuron Sst gabaergic interneuron Pericyte Endothelial cell L6 corticothalamic-projecting glutamatergic cortical neuron Vascular leptomeningeal cell Perivascular macrophage Natural killer cell Smooth muscle cell L5 extratelencephalic projecting glutamatergic cortical neuron L2/3-6 intratelencephalic projecting glutamatergic neuron Microglial cell Oligodendrocyte L5/6 near-projecting glutamatergic neuron Plasma cell L6b glutamatergic neuron of the primary motor cortex Lamp5 gabaergic interneuron Pvalb gabaergic interneuron T cell Astrocyte L2/3 intratelencephalic projecting glutamatergic neuron

Dorsolateral prefrontal cortex

69-year-old stage 83-year-old stage 77-year-old stage 80 year-old and over stage 81-year-old stage 87-year-old stage 64-year-old stage 79-year-old stage 66-year-old stage 68-year-old stage 82-year-old stage 78-year-old stage 67-year-old stage 89-year-old stage 86-year-old stage 54-year-old stage 80-year-old stage 65-year-old stage 71-year-old stage 76-year-old stage 85-year-old stage 74-year-old stage 75-year-old stage 72-year-old stage 73-year-old stage 88-year-old stage 70-year-old stage 84-year-old stage

Vascular dementia Lewy body dementia Parkinson disease Normal Frontotemporal dementia Tauopathy Head injury Alzheimer disease Diabetes mellitus Amyotrophic lateral sclerosis Dementia

Male Female

10x 3' v3

Nucleus

Homo sapiens

Diffuse bipolar 1 cell Giant bipolar cell Flat midget bipolar cell Retinal bipolar neuron Invaginating midget bipolar cell Diffuse bipolar 4 cell Diffuse bipolar 3a cell Rod bipolar cell Diffuse bipolar 2 cell Offx cell On-blue cone bipolar cell Diffuse bipolar 6 cell Diffuse bipolar 3b cell

Peripheral region of retina Macula lutea proper Macula lutea Fovea centralis

69-year-old stage 83-year-old stage 77-year-old stage 80 year-old and over stage 81-year-old stage 47-year-old stage 60-79 year-old stage 25-year-old stage 90 year-old and over stage 64-year-old stage 10-year-old stage 50-year-old stage 18-year-old stage 66-year-old stage 68-year-old stage Eighth decade stage 82-year-old stage 78-year-old stage 67-year-old stage Late adult stage 63-year-old stage 86-year-old stage 21-year-old stage 80-year-old stage 65-year-old stage 58-year-old stage 32-year-old stage 11-year-old stage 30-year-old stage 71-year-old stage 60-year-old stage 76-year-old stage 41-year-old stage 34-year-old stage 85-year-old stage 16-year-old stage 74-year-old stage 62-year-old stage 75-year-old stage 72-year-old stage 15-year-old stage 43-year-old stage 27-year-old stage 46-year-old stage 17-year-old stage 73-year-old stage Prime adult stage 88-year-old stage 24-year-old stage 52-year-old stage 53-year-old stage 70-year-old stage 3-year-old stage 84-year-old stage

Normal

Male Female

10x 3' v3

Nucleus

Homo sapiens

B cell Memory b cell Naive b cell Innate lymphoid cell Naive thymus-derived cd4-positive, alpha-beta t cell Gamma-delta t cell Regulatory t cell Natural killer cell Double negative thymocyte Cd14-positive monocyte Effector memory cd4-positive, alpha-beta t cell Plasmablast Central memory cd4-positive, alpha-beta t cell Hematopoietic precursor cell Effector memory cd8-positive, alpha-beta t cell Mucosal invariant t cell Naive thymus-derived cd8-positive, alpha-beta t cell Cd4-positive, alpha-beta t cell Central memory cd8-positive, alpha-beta t cell Plasmacytoid dendritic cell Cd1c-positive myeloid dendritic cell Cd14-low, cd16-positive monocyte Platelet Cd16-negative, cd56-bright natural killer cell, human Cd141-positive myeloid dendritic cell

Blood

20-year-old stage

Normal

Male

Scalebio single cell rna sequencing

Cell

Homo sapiens

Kidney proximal convoluted tubule epithelial cell Macrophage Blood vessel smooth muscle cell Kidney interstitial fibroblast Kidney loop of henle thick ascending limb epithelial cell Endothelial cell Podocyte Leukocyte Macula densa epithelial cell Kidney collecting duct principal cell Kidney collecting duct intercalated cell Kidney granular cell Mesangial cell Kidney distal convoluted tubule epithelial cell

Renal medulla Cortex of kidney

56-year-old stage 64-year-old stage 50-year-old stage 54-year-old stage 65-year-old stage 62-year-old stage 72-year-old stage 53-year-old stage

Normal

Male Female

Slide-seqv2

Homo sapiens

Oligodendrocyte precursor cell Macrophage Pericyte Hippocampal pyramidal neuron Endothelial cell Mature microglial cell Vascular leptomeningeal cell Hippocampal interneuron Smooth muscle cell of the brain vasculature Vascular associated smooth muscle cell Hippocampal granule cell Oligodendrocyte Hippocampal astrocyte T cell Ependymal cell

Hippocampal formation

79-year-old stage 50-year-old stage 40-year-old stage 48-year-old stage 54-year-old stage 42-year-old stage 60-year-old stage 51-year-old stage 26-year-old stage 29-year-old stage 37-year-old stage 24-year-old stage 44-year-old stage

Normal

Male Female

10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

Monocyte Large pre-b-ii cell Immature b cell Macrophage Conventional dendritic cell Fibroblast Myelocyte Innate lymphoid cell Late pro-b cell Alveolar type 1 fibroblast cell Group 3 innate lymphoid cell, human Regulatory t cell Common myeloid progenitor Granulocyte Endothelial cell Erythroid lineage cell Granulocyte monocyte progenitor cell Cd16-positive, cd56-dim natural killer cell, human Cd8-positive, alpha-beta t cell Natural killer cell Smooth muscle cell Megakaryocyte progenitor cell Megakaryocyte-erythroid progenitor cell Cd14-positive monocyte Group 1 innate lymphoid cell Neutrophil Epithelial cell of distal tubule Lung secretory cell Fraction a pre-pro b cell Pro-t cell Early pro-b cell Dendritic cell Cd4-positive, alpha-beta t cell Precursor b cell Hematopoietic multipotent progenitor cell Lung pericyte Early lymphoid progenitor Plasmacytoid dendritic cell Mature b cell Ciliated cell Pro-b cell Cd14-low, cd16-positive monocyte Cd16-negative, cd56-bright natural killer cell, human Mast cell Alveolar adventitial fibroblast Group 2 innate lymphoid cell Cd22-positive, cd38-low small pre-b cell Megakaryocyte

Lung

9th week post-fertilization stage 10th week post-fertilization stage 12th week post-fertilization stage Carnegie stage 23 15th week post-fertilization stage 11th week post-fertilization stage Carnegie stage 20 14th week post-fertilization stage 18th week post-fertilization stage 20th week post-fertilization stage 17th week post-fertilization stage 16th week post-fertilization stage Carnegie stage 22 Carnegie stage 16 Carnegie stage 13 Carnegie stage 19 21st week post-fertilization stage 13th week post-fertilization stage 22nd week post-fertilization stage

Normal

Male Female

10x 5' transcription profiling 10x 3' v2 10x 5' v1

Cell

Homo sapiens

Neuron Pericyte Myeloid cell Endothelial cell Malignant cell Oligodendrocyte Astrocyte Lymphocyte

Glioblastoma

10x 5' v3

Homo sapiens

Monocyte Immature b cell B cell Ilc1, human T-helper 22 cell T-helper 2 cell T follicular helper cell Iga plasma cell Naive b cell T-helper 17 cell Naive thymus-derived cd4-positive, alpha-beta t cell Erythroid progenitor cell, mammalian Effector cd8-positive, alpha-beta t cell Gamma-delta t cell Igm plasma cell Regulatory t cell Myeloid dendritic cell Erythrocyte Cd16-positive, cd56-dim natural killer cell, human Cd8-positive, alpha-beta t cell Natural killer cell Cd14-positive monocyte Group 2 innate lymphoid cell, human Effector memory cd4-positive, alpha-beta t cell Plasmablast Central memory cd4-positive, alpha-beta t cell Dendritic cell, human Igg plasma cell Dendritic cell Hematopoietic precursor cell Effector memory cd8-positive, alpha-beta t cell Mucosal invariant t cell Naive thymus-derived cd8-positive, alpha-beta t cell Cd4-positive, alpha-beta t cell Malignant cell Cd34-positive, cd38-negative hematopoietic stem cell Unswitched memory b cell Plasmacytoid dendritic cell Mature nk t cell Cd14-low, cd16-positive monocyte Platelet T-helper 1 cell Cd16-negative, cd56-bright natural killer cell, human Class switched memory b cell Megakaryocyte Myeloid lineage restricted progenitor cell

Blood

69-year-old stage 56-year-old stage 83-year-old stage 77-year-old stage 47-year-old stage 87-year-old stage 25-year-old stage 64-year-old stage Fourth decade stage 50-year-old stage 38-year-old stage 66-year-old stage 68-year-old stage 40-year-old stage 49-year-old stage Eighth decade stage Ninth decade stage 63-year-old stage 21-year-old stage 31-year-old stage 54-year-old stage 80-year-old stage 65-year-old stage 58-year-old stage 92-year-old stage 30-year-old stage 71-year-old stage 60-year-old stage 39-year-old stage 76-year-old stage Fifth decade stage 51-year-old stage 26-year-old stage 62-year-old stage 59-year-old stage 57-year-old stage Sixth decade stage 46-year-old stage 73-year-old stage 52-year-old stage 55-year-old stage 70-year-old stage 44-year-old stage Seventh decade stage 84-year-old stage Third decade stage

Normal Respiratory system disorder Covid-19

Male Female

10x 3' transcription profiling

Cell

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Primary auditory cortex Angular gyrus Anterior cingulate cortex Primary somatosensory cortex Middle temporal gyrus Primary motor cortex Dorsolateral prefrontal cortex Primary visual cortex

50-year-old stage 42-year-old stage 60-year-old stage 43-year-old stage 29-year-old stage Sixth decade stage

Normal

Male Female

10x 3' v3

Nucleus