Homo sapiens

T cell Natural killer cell Gamma-delta t cell Plasmacytoid dendritic cell Cd8-positive, alpha-beta memory t cell Cd8-positive, alpha-beta cytotoxic t cell Regulatory t cell Plasma cell B cell Naive thymus-derived cd4-positive, alpha-beta t cell Memory t cell

Liver

66-year-old stage 75-year-old stage 53-year-old stage 68-year-old stage 55-year-old stage 28-year-old stage 72-year-old stage 49-year-old stage 58-year-old stage Adult stage 67-year-old stage 77-year-old stage 33-year-old stage 64-year-old stage 46-year-old stage 73-year-old stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell Nucleus

Homo sapiens

Periportal region hepatocyte Endothelial cell of periportal hepatic sinusoid Hepatic pit cell Centrilobular region hepatocyte Kupffer cell Midzonal region hepatocyte Hepatic stellate cell Macrophage Endothelial cell of pericentral hepatic sinusoid Plasma cell Cd4-positive, alpha-beta t cell Vein endothelial cell Monocyte Vascular associated smooth muscle cell Fibroblast Intrahepatic cholangiocyte

Caudate lobe of liver

Late adult stage Postnatal stage Prime adult stage Young adult stage

Primary sclerosing cholangitis Primary biliary cholangitis Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Oligodendrocyte precursor cell

Brodmann (1909) area 13 Brodmann (1909) area 14 Brodmann (1909) area 19 Brodmann (1909) area 23 Brodmann (1909) area 24 Brodmann (1909) area 25 Brodmann (1909) area 32 Brodmann (1909) area 35 Brodmann (1909) area 38 Brodmann (1909) area 40 Brodmann (1909) area 43 Brodmann (1909) area 46 Accessory basal amygdaloid nucleus Agranular insular cortex Anterior cortical amygdaloid nucleus Anterior nuclear group Anterior olfactory nucleus Basolateral amygdaloid nuclear complex Bed nucleus of stria terminalis Body of caudate nucleus Central amygdaloid nucleus Centromedian nucleus of thalamus Cerebellar nuclear complex Cerebellar vermis Cerebrocerebellum Claustrum of brain Corticomedial nuclear complex Cuneus cortex Dentate gyrus of hippocampal formation Dorsal tegmental nucleus Epithalamus Extrastriate cortex Globus pallidus Granular insular cortex Gray matter of midbrain Hippocampal field Hypothalamus Inferior frontal gyrus Inferior olivary complex Inferior temporal gyrus Intralaminar nuclear group Lateral amygdaloid nucleus Lateral entorhinal cortex Lateral geniculate body Lateral nuclear group of thalamus Lateral posterior nucleus of thalamus Mammillary body Medial dorsal nucleus of thalamus Medial entorhinal cortex Medial geniculate body Medial zone of hypothalamus Median tuberal portion Midbrain nucleus Midbrain tectum Middle temporal gyrus Nucleus accumbens Nucleus of dorsal thalamus Nucleus of medulla oblongata Parabrachial nucleus Perirhinal cortex Piriform cortex Pontine nuclear group Pontine reticular formation Pontine tegmentum Posterior parahippocampal gyrus Preoptic area Pretectal region Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Pulvinar nucleus Putamen Red nucleus Retrosplenial region Rostral ca3 Septal nuclear complex Spinal cord Subicular complex Substantia innominata Substantia nigra Subthalamic nucleus Superior parietal cortex Superior temporal gyrus Supraoptic nucleus Temporal fusiform gyrus Uncal ca1 Ventral anterior nucleus of thalamus

42-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

T cell Neutrophil Neural stem cell Natural killer cell Glutamatergic neuron Oligodendrocyte precursor cell Arachnoid barrier cell Endothelial cell Hypendymal cell Oligodendrocyte Neuroendocrine cell Vascular leptomeningeal cell Cholinergic neuron Tanycyte Dopaminergic neuron Ependymal cell Macrophage Microglial cell Immature astrocyte Olfactory ensheathing cell Choroid plexus epithelial cell B cell Pericyte Monocyte Vascular associated smooth muscle cell Astrocyte Dendritic cell Gabaergic neuron

Normal

10x 3' v2

Homo sapiens

Vip gabaergic interneuron

Middle temporal gyrus

69-year-old stage 75-year-old stage 65-year-old stage 89-year-old stage 43-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage Adult stage 77-year-old stage 86-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Dorsolateral prefrontal cortex

69-year-old stage 75-year-old stage 42-year-old stage 89-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 77-year-old stage 86-year-old stage 70-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

Dopaminergic neuron Neuron

Substantia nigra pars compacta

91-year-old stage 92-year-old stage 82-year-old stage 90-year-old stage 49-year-old stage 79-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Endothelial cell Cycling stromal cell Endothelial cell of artery Capillary endothelial cell Endothelial cell of vascular tree Vein endothelial cell Pericyte Vascular associated smooth muscle cell Myofibroblast cell Fibroblast

Breast

66-year-old stage 69-year-old stage Middle aged stage 65-year-old stage 42-year-old stage 43-year-old stage Sixth decade stage 71-year-old stage 85-year-old stage 61-year-old stage 88-year-old stage 52-year-old stage 54-year-old stage 30-year-old stage 29-year-old stage 38-year-old stage Fifth decade stage 55-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 57-year-old stage 80 year-old and over stage 49-year-old stage 35-year-old stage Seventh decade stage 58-year-old stage 59-year-old stage 25-year-old stage Adult stage 67-year-old stage Late adult stage 32-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 60-79 year-old stage 36-year-old stage 63-year-old stage Eighth decade stage 47-year-old stage 73-year-old stage 83-year-old stage Prime adult stage Ninth decade stage

Invasive ductal breast carcinoma Breast cancer Estrogen-receptor positive breast cancer Breast apocrine carcinoma Invasive lobular breast carcinoma Metaplastic breast carcinoma Her2 positive breast carcinoma Breast mucinous carcinoma Triple-negative breast carcinoma Invasive tubular breast carcinoma Breast carcinoma

Female Male

10x 5' v2 10x 5' transcription profiling 10x 5' v1 10x 3' v3 10x 3' v2

Cell

Mus musculus

Enteric neuron Peripheral nervous system neuron Sympathetic neuron Spiral ganglion neuron Parasympathetic neuron Sensory neuron of dorsal root ganglion

Embryo

Theiler stage 22 Theiler stage 27 Theiler stage 24 Theiler stage 18 Theiler stage 25 Theiler stage 14 Theiler stage 16 Theiler stage 17 Theiler stage 15 Theiler stage 19 Theiler stage 26 Theiler stage 13 Theiler stage 20 Theiler stage 12 Theiler stage 21 Theiler stage 23

Normal

Female Male

Sci-rna-seq3

Nucleus

Mus musculus

Glutamatergic neuron Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Microglial cell Leptomeningeal cell Pericyte Astrocyte Gabaergic neuron Neural progenitor cell

Anterior olfactory nucleus Caudate-putamen Cerebral cortex Dentate gyrus of hippocampal formation Hippocampal field Lateral septal complex Neocortex Nucleus accumbens Olfactory cortex Orbitofrontal cortex Pallidum Piriform cortex Prefrontal cortex Primary auditory cortex Primary motor cortex Primary somatosensory cortex Secondary somatosensory cortex

8-week-old stage

Normal

Male

Snmc-seq2

Nucleus

Mus musculus

Glutamatergic neuron Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Microglial cell Leptomeningeal cell Pericyte Astrocyte Gabaergic neuron Neural progenitor cell

Anterior olfactory nucleus Caudate-putamen Cerebral cortex Dentate gyrus of hippocampal formation Hippocampal field Lateral septal complex Neocortex Nucleus accumbens Olfactory cortex Orbitofrontal cortex Pallidum Piriform cortex Prefrontal cortex Primary auditory cortex Primary motor cortex Primary somatosensory cortex Secondary somatosensory cortex

8-week-old stage

Normal

Male

Snmc-seq2

Nucleus

Homo sapiens

Osteoblast Neutrophil Muscle cell Endothelial tip cell Natural killer cell Erythrocyte Endothelial cell Mature nk t cell Pro-b cell Endothelial cell of sinusoid Myeloid lineage restricted progenitor cell Mast cell Cd8-positive, alpha-beta t cell Preosteoblast Schwann cell Plasmacytoid dendritic cell Muscle precursor cell Precursor b cell Lymphoid lineage restricted progenitor cell Early lymphoid progenitor Basophil mast progenitor cell Common dendritic progenitor Adipocyte Primitive red blood cell Macrophage Regulatory t cell Myelocyte Macrophage dendritic cell progenitor Immature innate lymphoid cell Promonocyte Common myeloid progenitor Cd4-positive, alpha-beta t cell Cd14-positive monocyte Hematopoietic multipotent progenitor cell Eosinophil Megakaryocyte Endosteal cell Precursor cell Granulocyte monocyte progenitor cell Progenitor cell Promyelocyte Immature natural killer cell Immature b cell Megakaryocyte-erythroid progenitor cell Fraction a pre-pro b cell Naive b cell Myofibroblast cell Basophil Fibroblast Osteoclast Dendritic cell Cd16-negative, cd56-bright natural killer cell, human Chondrocyte

Bone marrow

19th week post-fertilization stage 13th week post-fertilization stage 14th week post-fertilization stage 15th week post-fertilization stage 17th week post-fertilization stage 16th week post-fertilization stage

Normal

Female Male

10x 5' v1 10x 3' v2

Cell