Homo sapiens

T cell Neutrophil Respiratory tract goblet cell Myoepithelial cell of bronchus submucosal gland Tracheobronchial serous cell Natural killer cell Endothelial cell of lymphatic vessel Multiciliated columnar cell of tracheobronchial tree Pulmonary capillary endothelial cell Serous cell of epithelium of lobular bronchiole Mucus secreting cell of bronchus submucosal gland Mature nk t cell Mast cell Pulmonary ionocyte Cd8-positive, alpha-beta t cell Pulmonary neuroendocrine cell Blood vessel smooth muscle cell Lung resident memory cd8-positive, alpha-beta t cell Bronchiolar smooth muscle cell Lung microvascular endothelial cell Endothelial cell of artery Schwann cell Plasmacytoid dendritic cell Alternatively activated macrophage Bronchus fibroblast of lung Macrophage Deuterosomal cell Pulmonary alveolar type 1 cell Respiratory basal cell Serous secreting cell of bronchus submucosal gland Fibroblast of lung Plasma cell Cd4-positive, alpha-beta t cell Respiratory tract suprabasal cell Vein endothelial cell of respiratory system B cell Pericyte Monocyte Vascular associated smooth muscle cell Conventional dendritic cell Fibroblast Pulmonary alveolar type 2 cell Chondrocyte

Bronchus Segmental bronchus Terminal bronchus

66-year-old stage 37-year-old stage 65-year-old stage 61-year-old stage 39-year-old stage 56-year-old stage 57-year-old stage 12-year-old stage 24-year-old stage 58-year-old stage 67-year-old stage 32-year-old stage 41-year-old stage 63-year-old stage 20-year-old stage 11-year-old stage

Chronic obstructive pulmonary disease Normal

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

T cell Igm plasma cell Mast cell Iga plasma cell Epithelial cell Igg plasma cell Gut endothelial cell Glial cell B cell Myeloid leukocyte Fibroblast

Functional gastric disease

10x 3' v2

Homo sapiens

Endothelial cell

Heart right ventricle Apex of heart Heart left ventricle Interventricular septum

Pediatric stage Sixth decade stage Fifth decade stage Third decade stage Seventh decade stage Postnatal stage Fourth decade stage Eighth decade stage

Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Normal Non-compaction cardiomyopathy

Female Male

10x 3' v3 10x 3' v2

Nucleus

Mus musculus

Glioblast Central nervous system macrophage Glutamatergic neuron Oligodendrocyte Erythroid lineage cell Cerebellar granule cell Brain vascular cell Ependymal cell Microglial cell Neuroblast (sensu vertebrata) Immature astrocyte Meningeal macrophage Motor neuron Interneuron Noradrenergic cell Bergmann glial cell Macroglial cell Cerebellar granule cell precursor Purkinje cell Unipolar brush cell Gabaergic neuron

Cerebellar hemisphere Cerebellum

Theiler stage 22 Theiler stage 27 Theiler stage 18 Theiler stage 25 2-week-old stage Theiler stage 20 2-month-old stage 4-day-old stage 7-day-old stage Theiler stage 21 Theiler stage 23

Normal

Female Male

10x 3' v3 10x 3' v2

Nucleus

Mus musculus

Cell

Normal

Mixed sex

10x 3' v2

Homo sapiens

Oligodendrocyte precursor cell Oligodendrocyte Vascular leptomeningeal cell Pvalb chandelier gabaergic interneuron Lamp5 gabaergic interneuron Microglial cell Vip gabaergic interneuron L2/3-6 intratelencephalic projecting glutamatergic neuron L5 extratelencephalic projecting glutamatergic cortical neuron L6b glutamatergic cortical neuron Pvalb gabaergic interneuron Near-projecting glutamatergic cortical neuron Cerebral cortex endothelial cell Caudal ganglionic eminence derived interneuron Sncg gabaergic interneuron Astrocyte of the cerebral cortex Sst gabaergic interneuron Corticothalamic-projecting glutamatergic cortical neuron

Primary motor cortex

42-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Brown adipocyte Brown preadipocyte Adipocyte

Embryo

Theiler stage 22 Theiler stage 27 Theiler stage 24 Theiler stage 25 Theiler stage 26 Theiler stage 20 Theiler stage 23

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Oligodendrocyte precursor cell Oligodendrocyte Vascular leptomeningeal cell Pvalb chandelier gabaergic interneuron Lamp5 gabaergic interneuron Microglial cell Vip gabaergic interneuron L2/3-6 intratelencephalic projecting glutamatergic neuron L5 extratelencephalic projecting glutamatergic cortical neuron L6b glutamatergic cortical neuron Pvalb gabaergic interneuron Near-projecting glutamatergic cortical neuron Cerebral cortex endothelial cell Caudal ganglionic eminence derived interneuron Sncg gabaergic interneuron Astrocyte of the cerebral cortex Sst gabaergic interneuron Corticothalamic-projecting glutamatergic cortical neuron

Dorsolateral prefrontal cortex

42-year-old stage 43-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Blood vessel smooth muscle cell Endothelial cell of artery Lymphocyte Macrophage Microcirculation associated smooth muscle cell Fibroblast

Iliac artery Coronary artery Pulmonary artery Abdominal aorta Carotid artery segment Ascending aorta Arch of aorta Right coronary artery Bulb of aorta Descending aorta

69-year-old stage 48-year-old stage 39-year-old stage 38-year-old stage 67-year-old stage 46-year-old stage

Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Microglial cell Neuron Astrocyte

Frontal cortex

66-year-old stage 65-year-old stage 88-year-old stage 68-year-old stage 84-year-old stage 82-year-old stage 74-year-old stage 58-year-old stage 67-year-old stage 62-year-old stage 86-year-old stage 70-year-old stage 63-year-old stage 73-year-old stage 83-year-old stage 96-year-old stage

Frontotemporal dementia Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Central memory cd4-positive, alpha-beta t cell T cell Effector cd8-positive, alpha-beta t cell Natural killer cell Gamma-delta t cell Cd8-positive, alpha-beta t cell Platelet Plasmacytoid dendritic cell, human Cd8-positive, alpha-beta cytotoxic t cell Naive thymus-derived cd8-positive, alpha-beta t cell Effector memory cd4-positive, alpha-beta t cell, terminally differentiated Plasma cell Cd14-positive monocyte Cd14-low, cd16-positive monocyte B cell Naive thymus-derived cd4-positive, alpha-beta t cell Transitional stage b cell Central memory cd8-positive, alpha-beta t cell

Hiv infectious disease

10x 3' v3

Drosophila melanogaster

Adult somatic muscle cell of head Epidermal cell Outer photoreceptor cell Optic-lobe-associated cortex glial cell Transmedullary y neuron tmy8 T2 neuron Adult lamina marginal glial cell Transmedullary y neuron tmy4 Gamma kenyon cell Transmedullary neuron tm3 Subperineurial glial cell Somatic muscle cell Alpha/beta kenyon cell Transmedullary neuron tm1 Proximal medullary amacrine neuron pm2 Alpha'/beta' kenyon cell Photoreceptor cell r7 Lamina wide-field 2 neuron Lobula columnar neuron lc10 Distal medullary amacrine neuron dm10 T3 neuron Adult optic chiasma glial cell Centrifugal neuron c2 Lamina monopolar neuron l4 Photoreceptor cell r8 Hemocyte Ocellar retinula cell Proximal medullary amacrine neuron pm4 Antennal lobe projection neuron Johnston organ neuron Lobula columnar neuron lc12 Ensheathing glial cell Transmedullary neuron tm2 Transmedullary neuron tm9 Transmedullary neuron tm20 Transmedullary neuron tm5c Lamina monopolar neuron l2 Distal medullary amacrine neuron dm8a Distal medullary amacrine neuron dm9 Lamina wide-field 1 neuron Adult lamina epithelial glial cell Distal medullary amacrine neuron dm12 Medulla intrinsic neuron mi4 Lamina monopolar neuron l3 Auditory sensory neuron Distal medullary amacrine neuron dm11 Inner photoreceptor cell Columnar neuron t1 Adult olfactory receptor neuron gr21a/63a Primary pigment cell Transmedullary y neuron tmy14 Kenyon cell T4 neuron Adult brain perineurial glial cell Centrifugal neuron c3 Olfactory receptor neuron Gravity sensitive johnston organ neuron Adult astrocyte-like glial cell Photoreceptor cell of bolwig organ T2a neuron Distal medullary amacrine neuron dm3 T5 neuron Medulla intrinsic neuron mi15 Transmedullary y neuron tmy5a Dopaminergic neuron Adult dopaminergic pam neuron Medulla intrinsic neuron mi1 Adult lobula astrocyte-like glial cell Medulla intrinsic neuron mi9 Pigment cell Transmedullary neuron tm4 Adult brain cell body glial cell Lamina monopolar neuron l5 Cone cell Lamina monopolar neuron l1 Lobula columnar neuron lc17

Head

Day 5 of adulthood

Normal

Mixed sex Female Male

10x 3' v3