Homo sapiens

Cd14-low, cd16-positive monocyte Naive thymus-derived cd4-positive, alpha-beta t cell Regular atrial cardiac myocyte B cell Endothelial cell of artery Glial cell Pericyte Endothelial cell of lymphatic vessel Neutrophil Monocyte Cd8-positive, alpha-beta cytotoxic t cell Smooth muscle cell Macrophage Fibroblast of cardiac tissue Adipocyte Smooth muscle cell of the pulmonary artery Endothelial cell Cd14-positive monocyte Dendritic cell, human Endocardial cell Activated cd4-positive, alpha-beta t cell Vein endothelial cell Plasma cell Mast cell Mucosal invariant t cell Cardiac pacemaker cell of sinoatrial node

Sinoatrial node

Third decade stage

Normal

Female

Visium spatial gene expression v1

Homo sapiens

B cell Iga plasma cell Cd8-positive, alpha-beta cytotoxic t cell Duct epithelial cell Cd4-positive, alpha-beta t cell Macrophage Endothelial cell Fibroblast Acinar cell of salivary gland

Labial gland

55-year-old stage 52-year-old stage

Sjogren syndrome

Female

Visium spatial gene expression v1

Homo sapiens

Pulmonary alveolar type 2 cell Bronchus fibroblast of lung Club cell Endothelial cell of artery Lung multiciliated epithelial cell Epithelial cell of lung Fibroblast of lung Cd4-positive, alpha-beta t cell Myofibroblast cell Macrophage Tracheobronchial smooth muscle cell Respiratory tract epithelial cell Erythrocyte Vascular associated smooth muscle cell Pulmonary alveolar type 1 cell Vein endothelial cell Pulmonary neuroendocrine cell Pulmonary interstitial fibroblast Mesothelial cell

Lung

20th week post-fertilization stage

Normal

Male

Visium spatial gene expression v1

Homo sapiens

Hepatocyte Cholangiocyte Non-classical monocyte Kupffer cell Endothelial cell of periportal hepatic sinusoid Macrophage Erythrocyte Vascular associated smooth muscle cell Fibroblast Plasma cell

Liver

58-year-old stage

Normal

Male

Visium spatial gene expression v1

Homo sapiens

Goblet cell T-helper 17 cell Regulatory t cell B cell Enterocyte Iga plasma cell Malignant cell Cd4-positive, alpha-beta t cell Cd8-positive, alpha-beta t cell Igg plasma cell Endothelial tip cell Inflammatory macrophage Stromal cell Transit amplifying cell of colon

Rectum

Eighth decade stage

Colorectal cancer

Male

Visium spatial gene expression v1

Homo sapiens

Plasmacytoid dendritic cell Hepatocyte Hepatic stellate cell Cholangiocyte Non-classical monocyte Conventional dendritic cell Macrophage Endothelial cell of pericentral hepatic sinusoid Vascular associated smooth muscle cell Basophil Fibroblast Plasma cell

Liver

68-year-old stage

Normal

Female

Visium spatial gene expression v1

Homo sapiens

Natural killer cell Regulatory t cell Basal cell of epidermis Basal cell Endothelial cell of vascular tree Suprabasal keratinocyte Fibroblast Plasma cell

Nose skin

72-year-old stage

Basal cell carcinoma

Female

Visium spatial gene expression v1

Homo sapiens

Intestine goblet cell Transit amplifying cell of small intestine Intestinal crypt stem cell of large intestine Progenitor cell Glial cell Enterocyte Gut endothelial cell Pericyte Intestinal crypt stem cell of small intestine Myofibroblast cell Enteroendocrine cell Inhibitory motor neuron Interstitial cell of cajal Transit amplifying cell of colon Enteric smooth muscle cell Interneuron Gut absorptive cell Fibroblast Mesothelial cell

Colon

13th week post-fertilization stage

Normal

Male

Visium spatial gene expression v1

Mus musculus

Plasmacytoid dendritic cell Hepatocyte Endothelial cell of hepatic sinusoid Peritoneal macrophage Cholangiocyte B cell Conventional dendritic cell Kupffer cell Endothelial cell of periportal hepatic sinusoid Macrophage Erythrocyte Endothelial cell of pericentral hepatic sinusoid Fibroblast Mesothelial cell

Liver

10-month-old stage

Metabolic dysfunction-associated steatotic liver disease

Male

Visium spatial gene expression v1

Homo sapiens

Cd14-low, cd16-positive monocyte Regular atrial cardiac myocyte B cell Endothelial cell of artery Glial cell Endothelial cell of lymphatic vessel Neutrophil Monocyte Smooth muscle cell Macrophage Fibroblast of cardiac tissue Adipocyte Smooth muscle cell of the pulmonary artery Endothelial cell Cd14-positive monocyte Dendritic cell, human Vein endothelial cell Plasma cell Mast cell Cardiac pacemaker cell of sinoatrial node

Sinoatrial node

Fifth decade stage

Normal

Male

Visium spatial gene expression v1

Mus musculus

Immature single positive thymocyte Epithelial cell of thymus Cd4-positive, alpha-beta thymocyte Double-positive, alpha-beta thymocyte

Thymus

6-week-old stage

Normal

Female

Visium spatial gene expression v1

Homo sapiens

Regular atrial cardiac myocyte Endothelial cell of artery Endothelial cell of lymphatic vessel Fibroblast of cardiac tissue Adipocyte Smooth muscle cell of the pulmonary artery Endocardial cell Mesothelial cell

Left cardiac atrium

Seventh decade stage

Normal

Male

Visium spatial gene expression v1